Results 61 to 70 of about 215,695 (266)

The influence of acrylate triblock copolymer embedded in matrix on composite structures’ responses to low-velocity impacts [PDF]

, 2012
In passive safety structures the use of composite materials has increased significantly recently due to their low specific mass and high energy absorption capacities.
Frédéric Leonardi, DENNEULIN, Sébastien, Sébastien Denneulin, LATAILLADE, Jean-Luc, Jean-Luc Lataillade, Philippe Viot, LEONARDI, Frédéric, VIOT, Philippe   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Mechanical protection for composite structures submitted to low energy impact [PDF]

, 2010
Composite materials are widely used in aeronautical structures. These materials can be submitted to low energy impacts like tool drop, routine operations… Such impacts can generate damages in the material that significantly reduce the structure strength.
Bouvet, Christophe, Valembois, Guy, Rivallant, Samuel, Fascio, Valia, Rahmé, Pierre   +4 more
core  

Penetration of a woven CFRP laminate by a high velocity steel sphere impacting at velocities of up to 1875 m/s [PDF]

, 2009
The impact of a woven 6 mm thick CFRP laminate has been subjected to impact by an annealed steel sphere up to velocities of 1875 m/s. It was observed that above a threshold impact energy, the percentage of kinetic energy dissipated by the laminate was ...
Hazell, P.J., Kister, G., Cooper, G.A., Hazell, Paul J., Cooper, G. A., Kister, Guillaume, Cowie, A., Stennett, Christopher, Stennett, C., Cowie, Andrew   +9 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Experimental investigation of impact on composite laminates with protective layers [PDF]

, 2012
This paper presents an experimental study of low energy impacts on composite plates covered with a protective layer. In service, composite materials are subjected to low energy impacts.
Bouvet, Christophe, Valembois, Guy, V. Fascio, Rivallant, Samuel, G. Valembois, Fascio, Valia, Rahmé, Pierre, P. Rahmé, C. Bouvet, S. Rivallant   +9 more
core   +1 more source

Low velocity impact response of CFRP and Al2024-T3 helicopter blade

International Journal of Aeronautics and Astronautics
A high level of safety is demanded in response to the foreign object damage (FOD) problem frequently encountered in aviation. For this reason, in this study, the effect of stone impact on a helicopter blade performed within the scope of FOD is ...
Sakine Kurtar, Gamze Yaman, Dilara Nur Bektaş, Seda Nur Özsunar, Mesut Uyaner   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Experimental study of sandwich structures as armour against medium-velocity impacts [PDF]

, 2013
An experimental impact study has been conducted on sandwich structures to identify and improve armour solutions for aeronautical applications. The objectives are to find the best configurations, i.e. the non-perforated targets with the minimal weight and
Bouvet, Christophe, Rivallant, Samuel, Kolopp, Amélie   +2 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source