Results 111 to 120 of about 11,848,296 (296)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A single-switch quadratic DC–DC converter with ultra-high voltage gain and low voltage stress on semiconductors

Scientific Reports
This study offers a single-switch ultra-high step-up DC–DC converter based on the quadratic configuration. In the proposed topology, the quadratic structure is integrated with an auxiliary circuit employing a three-winding coupled inductor. The converter
Meysam Gozali, Hadi Aghaei, Ebrahim Babaei, Mehran Sabahi   +3 more
doaj   +1 more source

Two-Switch Ultrahigh Step-Up DC–DC Converterer With Low Input Current Ripple and Low Switch Voltage Stress

IEEE Open Journal of Power Electronics
Existing high step-up DC-DC converters suffer from various issues, including limited voltage gain, high voltage stress on semiconductors, and high current ripple.
Vahid Abbasi, Mohammad Mehdi Kashani, Milad Rezaie, Dylan Dah-Chuan Lu   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Three-Switch Active-Clamp Forward Converter With Low Switch Voltage Stress and Wide ZVS Range for High-Input-Voltage Applications

, 2010
In low-to-medium power applications, an active-clamp forward (ACF) converter is popular for its simple structure and zero-voltage switching (ZVS) capability. However, the high voltage stress on switches can be a burden in high-input-voltage applications.
Moon, GunWoo, Park, Ki-Bum, Kim, Chong-Eun, Youn, Myung Joong   +3 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

High voltage gain switched z‐source inverter with low current stress

IET Power Electronics
This paper proposes a switched Z‐source inverter with high voltage gain and low current stress on elements. Also, a new switching method corresponding to the proposed topology is introduced.
Golaleh Zarei, Ebrahim Babaei, Mohammad Bagher Bannae Sharifian, Hadi Aghaei, Elias Shokati Asl   +4 more
doaj   +1 more source

A Dual-Pulse-Clock Double Edge Triggered Flip-Flop

, 2008
In this paper, a low voltage dual-pulse-clock double edge triggered D'flip-flop (DPDET) is proposed. The DPDET flip-flop uses a split output latch clocked by a short pulse train.
For Low Voltage
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A 19-Level Ninefold-Boost Inverter With Reduced Device Count and LDP-Limited Modified Hybrid PWM

IEEE Access
This paper presents a 19-level switched-capacitor multilevel inverter (SC-MLI) employing a hybrid pulse-width modulation (HPWM) strategy to simultaneously achieve high voltage gain, low component count, and enhanced capacitor utilization.
Hossein Mansourizadeh, Majid Hosseinpour, Ali Seifi   +2 more
doaj   +1 more source