Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Aqueous Biphasic Systems Based on Tetrabutylammonium Bromide for Extraction and Determination of Azorubine, Allura Red, Sunset Yellow, Tartrazine and Fast Green in Food Samples. [PDF]
Smirnova SV +4 more
europepmc +1 more source
Objective Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centered care and informing local service pathways and care guidelines or standards.
Sonia Ranelli +8 more
wiley +1 more source
Lower lobe mucus plug distribution and future respiratory exacerbations in tobacco-exposed individuals with and without COPD. [PDF]
Wan ES +15 more
europepmc +1 more source
Objective Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged ≥70 years old.
Amanda J. Rickard +15 more
wiley +1 more source
Advanced thermal management for next-generation engineering heat control using magnetized ternary nanofluid transport between two coaxial disks. [PDF]
Alharbi AF +3 more
europepmc +1 more source
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy +9 more
wiley +1 more source
Assessing Cumulative Musculoskeletal Strain in Automotive Mechanics: Insights from Real-World Occupational Analysis. [PDF]
Daneshmandi H +5 more
europepmc +1 more source
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan +7 more
wiley +1 more source
Effectiveness of surgical skin preparation solutions in orthopaedic surgery: A systematic review of the current comparative literature. [PDF]
Puga TB +4 more
europepmc +1 more source

