Results 51 to 60 of about 9,011,638 (234)

Treating a patient with lower back pain

Медицинский совет, 2019
Back pain is one of the most common causes of medical treatment and temporary disability, which makes the problem of rational therapy particularly relevant.
O. A. Shavlovskaya
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Phillip G. Back papers

, 1935
This collection contains documents and correspondence from the collection of Phillip Goldstein Back (1902-1979), a long-time resident of Little Rock and prominent Jewish ...
Back, Phillip Goldstein, 1902-1979
core   +1 more source

Exploratory evaluation of spinopelvic and lumbar parameters in adolescent athletes with isthmic spondylolisthesis: feasibility and reliability of upright MRI compared to radiography

Frontiers in Radiology
IntroductionIsthmic spondylolisthesis is prevalent among adolescent athletes (AA). Upright MRI (uMRI) offers a radiation-free alternative to radiographs, combining imaging of the loaded spine with detailed depiction of the adjacent structures. This study
Michael Cassel, Theresa Joost, Chase Slater, Frank Mayer, Tilman Engel   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Study on the Prevalence of Musculoskeletal Disorders among the Coalminers of Eastern Coalfields of India

International Journal of Occupational Safety and Health, 2012
Background: Mining is an ancient occupation, long recognized as being arduous and liable to injury and disease. The lifecycle of mining consists of exploration, mine development, mine operation, decommissioning and land rehabilitation.
Arunabha Bandyopadhyay, Samrat Dev, Somnath Gangopadhyay   +2 more
doaj   +3 more sources

Reliability of Ultrasonography to Assess Spinal Compression During Heavy Load Carriage

JOR Spine
Background Back pain and spinal injury are leading contributors to premature retirement, particularly in physically demanding occupations. Direct and practical methods of spinal assessment are needed to evaluate interventions aimed at reducing spinal ...
Sherrilyn Walters, Ben Hoffman, Celeste E. Coltman, Lester Walters, Muneeb Iqbal, Dean E. Mills   +5 more
doaj   +1 more source

Lower back pain syndrome under polyclinic conditions

Научно-практическая ревматология, 2013
Objective: to define the rate and nature of lower back pain (LBP) in outpatients seeking medical care at Republican Hospital One — National Center of Medicine in Yakutsk. Subjects and methods. A total of 1072 patients (343 (32%) males (mean age 44.9+14.9
Anna Efremovna Mikhailova, R N Zakharova, Sh F Erdes, V G Krivoshapkin, T A Romanova, O L Sidorova   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source