Results 61 to 70 of about 9,011,638 (234)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Lower Back Symptoms in Adolescent Soccer Players
Orthopaedic Journal of Sports Medicine, 2014 Background: There are little published data on factors relating to low back pain in the younger athletic population. Hypothesis: Independent predictors of recovery and return to participation in sports could be determined by event analysis, which ...
Talib Shah MBBS, MRes +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
The Effect of Neuromuscular Fatigue on the Spatiotemporal Coordination of Rowing
Applied SciencesWithin rowing, lower back disorders (LBDs) are common, but the mechanisms underpinning LBDs are poorly understood. Considering this, it is essential to understand how coordination and motor control change under different constraints such as ergometer ...
Carl J. Alano +3 more
doaj +1 more source
To nie jest kraj dla słabych ludzi [okładka płyty CD z tekstami piosenek
, 2009 1 dysk optyczny (CD) : digital, stereo. ; 12 cm; okładka płyty CD z książeczką z tekstami piosenek : Achtung! Achtung! ; Tylko dla dorosłych ; 3.40 ; Jeszcze rok ; Licytacja ; Pokaz mody ; Protokoły mędrców ; Przestrojenie ; Śmiech na sali ; Płonące ...
wykonawca Back to Reality
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Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
دراسات وبحوث التربية الرياضيةThe sedentary work environment is a major contributing factor to the prevalence of musculoskeletal disorders, particularly lower back pain, among office workers.
FL Naji +2 more
doaj +1 more source