Results 131 to 140 of about 13,257,834 (322)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Entropic Lower Bound for Distinguishability of Quantum States

Advances in Mathematical Physics, 2015
For a system randomly prepared in a number of quantum states, we present a lower bound for the distinguishability of the quantum states, that is, the success probability of determining the states in the form of entropy.
Seungho Yang, Jinhyoung Lee, Hyunseok Jeong   +2 more
doaj   +1 more source

Lower bound for mr (2,41) and related code [PDF]

BIO Web of Conferences
A (k, n) - arc is a set of k points of a projective plane such that some n, but no n+1 of them, are collinear. The maximum size of a (k, n) - arc in PG(2 q) is denoted by mr(2, q).
Yahya Hanan Maysar Sabih, Yahya Nada Yassen Kasm   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

How Low Can You Go? New Evidence Supports No Lower Bound to Low-Density Lipoprotein Cholesterol Level in Secondary Prevention. [PDF]

Circulation, 2023
Rodriguez F, Khera A.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Matrix-Wigner Distribution

Fractal and Fractional
In order to achieve time–frequency superresolution in comparison to the conventional Wigner distribution (WD), this study generalizes the well-known τ-Wigner distribution (τ-WD) with only one parameter τ to the multiple-parameter matrix-Wigner ...
Long Wang, Manjun Cui, Ze Qin, Zhichao Zhang, Jianwei Zhang   +4 more
doaj   +1 more source

Constructing Grith Eight GC-LDPC Codes Based on the GCD FLRM Matrix with a New Lower Bound. [PDF]

Sensors (Basel), 2022
Zhu K, Yang H.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Comparison of an improved self-consistent lower bound theory with Lehmann's method for low-lying eigenvalues. [PDF]

Sci Rep, 2021
Ronto M, Pollak E, Martinazzo R.
europepmc   +1 more source