Results 111 to 120 of about 13,257,834 (322)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Nonuniform ACC Circuit Lower Bounds [PDF]
Journal of the ACM, 2011 The class ACC consists of circuit families with constant depth over unbounded fan-in AND, OR, NOT, and MOD m gates, where m > 1 is an arbitrary constant. We prove the following. ---NEXP, the class of languages accepted in nondeterministic exponential time, does not ...
openaire +2 more sources
A Time‐Series Model of Interest Rates with the Effective Lower Bound
Journal of Money, Credit and Banking, 2016 Modeling interest rates over samples that include the Great Recession requires taking stock of the effective lower bound (ELB) on nominal interest rates.
Benjamin K. Johannsen, Elmar Mertens
semanticscholar +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Online makespan minimization for MapReduce scheduling on multiple parallel machines
Demonstratio MathematicaIn this work, we investigate the online MapReduce processing problem on mm uniform parallel machines, aiming at minimizing the makespan. Each job consists of two sets of tasks, namely, the map tasks and the reduce tasks.
Zheng Quanchang +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Comment on ``Rethinking the Lower Bound on Aerosol Radiative Forcing''
, 2017 In an influential and interesting study, Stevens (2015) suggested that the global and also Northern Hemispheric warming during the early industrial period implies that the effective radiative forcing by anthropogenic aerosols in the year 2000 compared to
J. Kretzschmar +4 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Topology, 2018 We prove a new lower bound for the dilatation of an arbitrary pseudo-Anosov map on a surface of genus g with n punctures. Our bound improves the former super-exponential dependence on the genus by a polynomial dependence.
openaire +5 more sources