Results 141 to 150 of about 5,110,730 (289)

Some lower bounds for maximum colored cuts

Open Mathematics
For an edge-colored graph, the Maximum Colored Cut problem is to find a bipartition maximizing the number of colors in edges going across the bipartition. This problem is a generalization of the classical Max-Cut problem.
Huawen Ma
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Isoperimetric problems and lower bounds on curvature

Analysis and Geometry in Metric Spaces
This note surveys some classical results and recent developments on the interplay between lower curvature bounds and the isoperimetric problem. It is based on mini-courses given at the European Doctorate School of Differential Geometry (Granada, July ...
Antonelli Gioacchino
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Tight analyses for subgradient descent I: Lower bounds

Open Journal of Mathematical Optimization
Consider the problem of minimizing functions that are Lipschitz and convex, but not necessarily differentiable. We construct a function from this class for which the $Tþ$ iterate of subgradient descent has error $\Omega (\log (T)/\sqrt{T})$. This matches
Harvey, Nicholas J. A., Liaw, Chris, Randhawa, Sikander   +2 more
doaj   +1 more source

Regression models using the LINEX loss to predict lower bounds for the number of points for approximating planar contour shapes. [PDF]

J Appl Stat, 2022
Jayasinghe JMT, Ellingson L, Prematilake C.   +2 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

On lower bounds for the energy of graphs

Arab Journal of Basic and Applied Sciences
The concept of the energy of a graph was introduced by Gutman in 1978, inspired by the Hückel molecular orbital theory, which approximates the total [Formula: see text]-electron energy of a conjugated hydrocarbon molecule using the energy of its ...
B. R. Rakshith, L. Yashaswini
doaj   +1 more source

Approximate Lower Bound Arguments

Suppose a prover, in possession of a large body of valuable evidence, wants to quickly convince a verifier by presenting only a small portion of the evidence. We define an Approximate Lower Bound Argument, or ALBA, which allows the prover to do just that: to succinctly prove knowledge of a large number of elements satisfying a predicate (or, more ...
Pyrros Chaidos, Aggelos Kiayias, Leonid Reyzin, Anatoliy Zinovyev   +3 more
openaire   +3 more sources