Results 71 to 80 of about 996,357 (278)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Hardness measures and resolution lower bounds [PDF]

open access: yes, 2014
Various "hardness" measures have been studied for resolution, providing theoretical insight into the proof complexity of resolution and its fragments, as well as explanations for the hardness of instances in SAT solving.
Beyersdorff, Olaf, Kullmann, Oliver
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Lower bounds for the expected sample size in the classical and d-posterior statistical problems

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2018
In this report, the problem of construction of lower boundaries for the expected sample size of statistical inference procedures has been considered. The general methodology for construction of the lower bounds and the review of the main results for the ...
I.A. Kareev, I.N. Volodin
doaj  

Some new bounds of the minimum eigenvalue for the Hadamard product of an M-matrix and an inverse M-matrix

open access: yesOpen Mathematics, 2016
Some convergent sequences of the lower bounds of the minimum eigenvalue for the Hadamard product of a nonsingular M-matrix B and the inverse of a nonsingular M-matrix A are given by using Brauer’s theorem.
Zhao Jianxing, Sang Caili
doaj   +1 more source

Asymptotic lower bounds in estimating jumps

open access: yes, 2014
We study the problem of the efficient estimation of the jumps for stochastic processes. We assume that the stochastic jump process $(X_t)_{t\in[0,1]}$ is observed discretely, with a sampling step of size $1/n$.
Clément, Emmanuelle   +2 more
core   +5 more sources

Noisy Radio Network Lower Bounds via Noiseless Beeping Lower Bounds

open access: yes, 2023
Much of today’s communication is carried out over large wireless systems with different input-output behaviors. In this work, we compare the power of central abstractions of wireless communication through the general notion of boolean symmetric f-channels: In every round of the f-channel, each of its n parties decides to either broadcast or not, and ...
Efremenko, Klim   +3 more
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Geometric lower bounds for generalized ranks [PDF]

open access: yes, 2014
We revisit a geometric lower bound for Waring rank of polynomials (symmetric rank of symmetric tensors) of Landsberg and Teitler and generalize it to a lower bound for rank with respect to arbitrary varieties, improving the bound given by the "non ...
Teitler, Zach
core  

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