Results 71 to 80 of about 1,003,788 (328)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Lower bounds on Herbrand’s theorem [PDF]
Proceedings of the American Mathematical Society, 1979 We give non Kalmar-elementary lower bounds on the elimination of quantifier inferences via Herbrand’s theorem.
openaire +1 more source
Multicut Lower Bounds via Network Coding
, 2013 We introduce a new technique to certify lower bounds on the multicut size using network coding. In directed networks the network coding rate is not a lower bound on the multicut, but we identify a class of networks on which the rate is equal to the size ...
Blasiak, Anna
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Optimal transport and timelike lower Ricci curvature bounds on Finsler spacetimes [PDF]
, 2023 Mathias Braun, Shin‐ichi Ohta
openalex +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Lower bounds for representation growth [PDF]
Journal of Group Theory, 2010 18 ...
openaire +2 more sources
Lower Bounds and Upper Bounds for MaxSAT [PDF]
, 2012 This paper presents several ways to compute lower and upperbounds for MaxSAT based on calling a complete SAT solver. Preliminary results indicate that (i) the bounds are of high quality, (ii) the bounds can boost the search of MaxSAT solvers on some benchmarks, and (iii) the upper bounds computed by a Stochastic Local Search procedure (SLS) can be ...
Heras, Federico +2 more
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source