Results 81 to 90 of about 96,047 (264)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Известия Иркутского государственного университета: Серия "Математика", 2016 The representations, including polynomial, of functions over final fields have been actively investigated. The complexity of such representations is the main stream of research.
A. Baliuk, A.S. Zinchenko
doaj
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Fractal and FractionalIn this paper, we prove the lower bounds of the blow-up time of solutions for certain Caputo time fractional diffusion equations and systems with nonlinear memory terms under homogeneous Dirichlet boundary conditions.
Quanguo Zhang, Yaning Li
doaj +1 more source
Some characterizations of error bound for non-lower semicontinuous functions
Journal of Inequalities and Applications, 2019 In this paper, we study the error bound of non-lower semicontinuous functions. First, we extend the concepts of strong slope and global slope to the non-lower semicontinuous functions.
Miantao Chao +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Tighter lower bounds on quantum annealing times
SciPost PhysicsWe derive lower bounds on the time needed for a quantum annealer to prepare the ground state of a target Hamiltonian. These bounds do not depend on the annealing schedule and can take the local structure of the Hamiltonian into account. Consequently, the
Luis Pedro García-Pintos, Mrunmay Sahasrabudhe, Christian Arenz
doaj +1 more source