Results 101 to 110 of about 5,110,730 (289)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Lower bounds for kernelizations
Electron. Colloquium Comput. Complex., 2007 "Vegeu el resum a l'inici del document del fitxer adjunt".
Yijia Chen 0001 +2 more
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Fractal and FractionalIn this paper, we prove the lower bounds of the blow-up time of solutions for certain Caputo time fractional diffusion equations and systems with nonlinear memory terms under homogeneous Dirichlet boundary conditions.
Quanguo Zhang, Yaning Li
doaj +1 more source
Some characterizations of error bound for non-lower semicontinuous functions
Journal of Inequalities and Applications, 2019 In this paper, we study the error bound of non-lower semicontinuous functions. First, we extend the concepts of strong slope and global slope to the non-lower semicontinuous functions.
Miantao Chao +2 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Tighter lower bounds on quantum annealing times
SciPost PhysicsWe derive lower bounds on the time needed for a quantum annealer to prepare the ground state of a target Hamiltonian. These bounds do not depend on the annealing schedule and can take the local structure of the Hamiltonian into account. Consequently, the
Luis Pedro García-Pintos, Mrunmay Sahasrabudhe, Christian Arenz
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A branch and bound algorithm for exact, upper, and lower bounds on treewidth
, 2006 . In this paper, a branch and bound algorithm for computing the treewidth of a graph is presented. The method incorporates extensions of existing results, and uses new pruning and reduction rules, based upon properties of the adopted branching strategy ...
Emgad H. Bachoore +2 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source