Results 61 to 70 of about 39,068 (353)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Unravelling the relative contributions of climate change and ground disturbance to subsurface temperature perturbations: Case studies from Tyneside, UK [PDF]

, 2016
When assessing subsurface urban heat islands (UHIs) it is important to distinguish between localized effects of land-use change and the impacts of global climate change. However, few investigations have successfully unraveled the two influences.
Westaway, Rob, Younger, Paul L.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Geological characteristics and main controlling factors of the helium-rich gas reservoirs in Sozak Gas Field, Kazakhstan

Journal of Natural Gas Geoscience
Based on core data, physical properties, well logging, gas testing, composition, and helium distribution from 13 newly drilled wells, in combination with regional tectonic evolution, depositional background, and typical gas reservoir profiles, helium ...
Xiaodan Gu, Chengzao Jia, Jianfa Chen, Lin Jiang   +3 more
doaj   +1 more source

Lead, zinc and copper mineralisation in basal Carboniferous sediments at Westwater, south Scotland [PDF]

, 1977
A zioneo f lead, zinc and copperm ineralisatioins developedo ver a minimum I of 4 km of strikeo f basal Carboniferoucse mentstoneg roup sedimentsa nd immediatelyu nderlyingB irrenswarkL avas atwestwater,n ear Laqholm in south Scotland.
Davies, A., Easterbrook, G.D., Fortey, N.J., Gallagher, M.J., Parker, M.E., Smith, R.T.   +5 more
core  

Gold in Devono-Carboniferous red beds of northern Britain [PDF]

, 2015
We are grateful to D. Craw and an anonymous reviewer for comments that helped to clarify the paper.
Bellis, David, Parnell, John, Spinks, Samuel, Still, John   +3 more
core   +1 more source

The Lower Carboniferous Rocks of Cumberland [PDF]

Geological Magazine, 1922
On glancing over back numbers of the GeologicalMagazine after eight months' residence abroad, I have been much interested to find a paper by Mr. C. Edmonds on the Carboniferous Limestone of West Cumberland.
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Molecular Compositions of Hydrocarbons Within the Lower and Middle Carboniferous Shale Sequences from the Outcrops in the Piedmont of Southwestern Tarim Basin and the Possible Geochemical Implications

Energies
The lower and middle Carboniferous shale sequences are one of the important potential hydrocarbon source rocks in the piedmont of the southwestern Tarim Basin, China (PSTB).
Xueyou Tan, Zhushi Ge, Suyang Cai, Qilin Xiao   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source