Results 61 to 70 of about 8,234,031 (344)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Polymetallic mineralisation in Carboniferous rocks at Hilderston, near Bathgate, central Scotland [PDF]

, 1983
Five boreholes in the vicinity of the ancient Ag-Ni-Pb mine at Hilderston, near Bathgate have yielded new stratigraphic, mineralogical and geochemical information.
Stephenson, D., Gallagher, M.J., Fortey, N.J.   +2 more
core  

Molecular Compositions of Hydrocarbons Within the Lower and Middle Carboniferous Shale Sequences from the Outcrops in the Piedmont of Southwestern Tarim Basin and the Possible Geochemical Implications

Energies
The lower and middle Carboniferous shale sequences are one of the important potential hydrocarbon source rocks in the piedmont of the southwestern Tarim Basin, China (PSTB).
Xueyou Tan, Zhushi Ge, Suyang Cai, Qilin Xiao   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Contributions to the Knowledge of Lower Carboniferous Plants. I. On the Genus Rhacopteris, Schimper. II. On the Morphology of Sphenopteris Teiliana, Kidston, and Its Bearing on the Position of the Fructification on the Frond of Some Lower Carboniferous Plants

The genus Rhacopteris was instituted by Schimper in 1869 for a type of fern-like frond of Carboniferous Age. It included one species Rhacopteris elegans , Ettingshausen sp.
J. Walton
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

K-feldspar sand-grain provenance in the Triassic, west of Shetland : distinguishing first-cycle and recycled sediment sources?

, 2009
Sandstone provenance studies can help constrain palaeogeographic reconstructions and ancient drainage system scales and pathways. However, these insights can be obscured by difficulties in geochemically distinguishing or adequately characterising ...
Daly, J. Stephen, Shane Tyrrell, Tyrrell, Shane, Leleu, Sophie, J. Stephen Daly, Souders, A. Kate, Haughton, Peter D. W., Peter D.W. Haughton, Sophie Leleu, A. Kate Souders   +9 more
core   +1 more source

Ancient karst at the eastern slope of the Middle Urals and the Early-Middle Carboniferous boundary

Литосфера, 2016
The paleokarst occurrences associated with Lower Carboniferous limestones in the east of the Middle Urals are considered. We analyse the nature of the Early-Middle Carboniferous boundary.
G. A. Mizens, L. V. Badida, T. I. Stepanova, N. A. Kucheva   +3 more
doaj   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source