Results 81 to 90 of about 4,836,614 (283)
LATE CARBONIFEROUS BRACHIOPODS FROM KARAKORUM, PAKISTAN
Carboniferous rocks from North Karakorum display sharp lateral variations in lithology and thickness suggesting accumulation in half-grabens during continental rifting between the Karakorum block and northern Gondwana. Different Carboniferous successions,
LUCIA ANGIOLINI +2 more
doaj +1 more source
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Organic geochemistry of Carboniferous and Lower Permian source rocks, Turpan-Hami Basin, NW China
Organic geochemistry characteristics of carbonate rock and mudstone samples are reported for cores in exploration wells and outcrops in the Carboniferous and Lower Permian, Turpan-Hami Basin.
Gao Gang +5 more
doaj +1 more source
Basaltic maar-diatreme volcanism in the Lower Carboniferous of the Limerick Basin (SW Ireland) [PDF]
Lead-zinc exploration drilling within the Limerick Basin (SW Ireland) has revealed the deep internal architecture and extra-crater deposits of five alkali-basaltic maar-diatremes.
Gernon, T.M. +5 more
core +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
The arm of the present paper is to evaluate the significance of species from genus Nikiforovella for stratigraphy of Devonian-Carboniferous boundary from different regions of Eurasia.
Zoya A. Tolokonnikova
doaj +2 more sources
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source

