Results 71 to 80 of about 9,813,321 (260)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Laboratory-Estimation of Lower Temperature Threshold and Thermal Constant (DDs) for Development of Spodoptera frugiperda and Spodoptera littoralis (Noctuidae: Lepidoptera) under Varying Temperature Regimes and Host Plants [PDF]

Journal of Plant Protection and Pathology
The fall armyworm, Spodoptera frugiperda and the cotton leafworm, Spodoptera littoralis are among themost important pests attacking several plant species and causing economic losses. Although, polyphagous speciescan feed on a wide range of plant species,
S. Awadalla, M. Olyme, Maram Hassan, M. Bayoumy   +3 more
doaj   +1 more source

The Stochastics of Threshold Accepting: Analysis of an Application to the Uniform Design Problem [PDF]

Threshold Accepting (TA) is a powerful optimization heuristic from the class of stochastic local search algorithms. It has been applied successfully to different optimization problems in statistics and econometrics, including the uniform design problem ...
Winker, Peter
core  

Temperature-Induced Self-Compensating Defect Traps and Gain Thresholds in Colloidal Quantum Dots

, 2019
Continuous-wave (CW) lasing was recently achieved in colloidal quantum dots (CQDs) by lowering the threshold through the introduction of biaxial strain. However, the CW laser threshold is still much higher than the femtosecond threshold.
Edward H. Sargent, Kristopher T. Bicanic (7023014), Randy P. Sabatini, Oleksandr Voznyy (1376316), Laxmi K. Sagar (7023017), Sjoerd Hoogland, Laxmi K. Sagar, Golam Bappi (7023011), Fengjia Fan (1487125), Golam Bappi, Randy P. Sabatini (1417690), Fengjia Fan, Makhsud I. Saidaminov, Sjoerd Hoogland (1454962), Makhsud I. Saidaminov (1371087), Edward H. Sargent (1363284), Oleksandr Voznyy, Kristopher T. Bicanic   +17 more
core   +1 more source

Temperature-Dependent THz Properties and Emission of Organic Crystal BNA

, 2023
As high-average power ultrafast lasers become increasingly available for nonlinear conversion, the temperature dependence of the material properties of nonlinear crystals becomes increasingly relevant.
Mostafa Shalaby (8082812), Clara J. Saraceno (3960995), Tim Vogel (10686890), Samira Mansourzadeh (14360424)   +3 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

When do Indians feel hot? Internet searches indicate seasonality suppresses adaptation to heat

Environmental Research Letters, 2018
In a warming world an increasing number of people are being exposed to heat, making a comfortable thermal environment an important need. This study explores the potential of using Regional Internet Search Frequencies (RISF) for air conditioning devices ...
Tanya Singh, Christian Siderius, Ype Van der Velde   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source