Results 51 to 60 of about 9,813,321 (260)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A novel over-temperature protection circuit for LED driver

Dianzi Jishu Yingyong
In this paper, a new type of over-temperature protection (OTP) circuit for LED driver is designed. It is based on 0.18μm BCD process. In this paper, Banba′s bandgap reference based on current summing is used to generate high and low threshold voltage, to
Wen Xin, Feng Quanyuan, Cheng Jian
doaj   +1 more source

Evolution of electrical performance of ZnO-based thin-film transistors by low temperature annealing

AIP Advances, 2012
The effects of post-annealing on performance of ZnO-based thin-film transistors (TFTs) fabricated at room temperature were investigated. It was observed that high-temperature annealing resulted in a large decrease in resistivity of the ZnO channel layer ...
J. Zhang, X. F. Li, J. G. Lu, P. Wu, J. Huang, Q. Wang, B. Lu, Y. Z. Zhang, B. H. Zhao, Z. Z. Ye   +9 more
doaj   +1 more source

Effect of temperature on rate of development, survival and adult longevity of Phthorimaea operculella (Lepidoptera: Gelechiidae)

European Journal of Entomology, 2017
The potato tuberworm, Phthorimaea operculella Zeller (Lepidoptera: Gelechiidae), is a major pest of potato, Solanum tuberosum L. (Solanales: Solanaceae), both in the field and storehouses. The rate of development and survival of P. operculella, reared on
Stefanos S. ANDREADIS, Christos G. SPANOUDIS, Georgia ZAKKA, Barbara ASLANIDOU, Sofia NOUKARI, Matilda SAVOPOULOU-SOULTANI   +5 more
doaj   +1 more source

Using Temperature of IR Sources for Assessing Photochemical and Aphakic Retinal Hazard [PDF]

Iranian Journal of Medical Physics, 2016
Introduction Blue light is a part of the spectrum with the highest energy content, which can reach the retina. The damage that it can cause to the retina is called photochemical or blue-light retinal injury.
Faramarz Madjidi
doaj   +1 more source

Effect of individual finger skin temperature on vibrotactile perception threshold [PDF]

, 2013
Objectives: In healthy people, the vibrotactile perception threshold (VPT) at fingertips depends on a given measurement method and on individual characteristics such as age, gender and finger skin temperature.
Harazin, Barbara, Kałamarz, Jacek, Barbara Harazin, Agnieszka Harazin-Lechowska, Jacek Kałamarz, Harazin-Lechowska, Agnieszka   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Threshold effects in cointegrating relationships [PDF]

, 2006
In this paper, we introduce threshold-type nonlinearities within a single-equation cointegrating regression model and propose a testing procedure for testing the null hypothesis of linear cointegration vs. cointegration with threshold effects.
Gonzalo, Jesús, Jean-Yves Pitarakis, Jesus Gonzalo, Pitarakis, Jean-Yves, Jes�s Gonzalo   +4 more
core   +2 more sources