Transcriptome analysis of
BMC Genomics, 2008 Background The bite of spiders belonging to the genus Loxosceles can induce a variety of clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis, and persistent inflammation.
Almeida Diego D +6 more
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Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. [PDF]
PLoS ONE, 2016 Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Mara A Corrêa +4 more
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Production and Functional Evaluation of Anti-Loxosceles Sera Raised by Immunizations of Rabbits with Mutated Recombinant Phospholipases-D [PDF]
Biomedicines, 2022 Loxoscelism is the clinical condition triggered after the bite of spiders of the genus Loxosceles. The main species involved in accidents in South America are L. intermedia, L. laeta, and L. gaucho.
Bruno Cesar Antunes +11 more
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Predictive analysis of B-cell antigenic epitopes in phospholipase D toxins from Loxosceles spiders [PDF]
Toxicon: XThe Phospholipase D (PLD) toxin family, a major component of the Loxosceles spider venom, is a valuable biotechnological tool for developing antivenom treatment and diagnostic assays to overcome and prevent loxoscelism.
Alejandro Catalán +10 more
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Binding of green tea epigallocatechin gallate to the arginine kinase active site from the brown recluse spider (Loxosceles laeta): A potential synergist to chemical pesticides [PDF]
HeliyonLoxosceles spp. spiders can cause serious public health issues. Chemical control is commonly used, leading to health and environmental problems. Identifying molecular targets and using them with natural compounds can help develop safer and eco-friendlier
Elena N. Moreno-Cordova +8 more
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First report of in vitro selection of RNA aptamers targeted to recombinant Loxosceles laeta spider toxins [PDF]
Biological Research, 2014 BACKGROUND: Loxoscelism is the envenomation caused by the bite of Loxosceles spp. spiders. It entails severe necrotizing skin lesions, sometimes accompanied by systemic reactions and even death.
Amalia Sapag +2 more
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Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands. [PDF]
PLoS ONE, 2016 The human complement system is composed of more than 30 proteins and many of these have conserved domains that allow tracing the phylogenetic evolution.
Daniela Tiemi Myamoto +5 more
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The tiniest violin: the male of Loxosceles vallenar (Araneae, Sicariidae) [PDF]
ZooKeysIn recent years, several endemic species of Loxosceles, violin spiders, have been described from the North-Central Chile biodiversity hotspot, some of which have ambiguous placement within the species groups of the genus.
Ivan L. F. Magalhaes +3 more
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Sphingomyelinase D Activity in Sicarius tropicus Venom: Toxic Potential and Clues to the Evolution of SMases D in the Sicariidae Family [PDF]
Toxins, 2021 The spider family Sicariidae includes three genera, Hexophthalma, Sicarius and Loxosceles. The three genera share a common characteristic in their venoms: the presence of Sphingomyelinases D (SMase D).
Priscila Hess Lopes +4 more
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Phospholipase D from Loxosceles laeta Spider Venom Induces IL-6, IL-8, CXCL1/GRO-α, and CCL2/MCP-1 Production in Human Skin Fibroblasts and Stimulates Monocytes Migration [PDF]
Toxins, 2017 Cutaneous loxoscelism envenomation by Loxosceles spiders is characterized by the development of a dermonecrotic lesion, strong inflammatory response, the production of pro-inflammatory mediators, and leukocyte migration to the bite site.
José M. Rojas +8 more
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