Results 161 to 170 of about 18,337 (203)
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Prostaglandins & Other Lipid Mediators, 2001
Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades.
N, Fukushima, J, Chun
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Lysophosphatidic acid (LPA) is a growth factor-like lipid that produces many cellular responses. These responses, including actin cytoskeletal rearrangements, cell proliferation and inhibition of gap junction communication, have been documented in many cell types over the last 2 decades.
N, Fukushima, J, Chun
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LPA receptor 2 mediates LPA-induced endometrial cancer invasion
Gynecologic Oncology, 2009We have previously shown that lysophosphatidic acid (LPA) promotes the ovarian cancer metastatic cascade. In this study, we evaluated the role of LPA on endometrial cancer invasion.Transient mRNA knockdown was accomplished using pre-designed siRNA duplexes against LPA receptor 2 (LPA2) and human matrix metalloproteinase-7 (MMP-7).
Joanie Mayer, Hope +6 more
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LPA Receptors: Subtypes and Biological Actions
Annual Review of Pharmacology and Toxicology, 2010Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signaling molecule by binding to and activating at least five known G protein–coupled receptors (GPCRs): LPA1–LPA5. They are encoded by distinct genes named LPAR1–LPAR5 in humans and Lpar1–Lpar5 in mice.
Ji Woong, Choi +10 more
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Lysophosphatidic acid (LPA) and its receptors
Current Opinion in Pharmacology, 2009Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi +3 more
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Autotaxin and LPA receptor signaling in cancer
Cancer and Metastasis Reviews, 2011Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that functions as a mitogen and motility factor for many cell types. LPA signals through six specific G protein-coupled receptors, named LPA(1-6), which trigger both overlapping and distinct signaling pathways.
Anna J S, Houben, Wouter H, Moolenaar
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Non-Edg family lysophosphatidic acid (LPA) receptors
Prostaglandins & Other Lipid Mediators, 2009Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a bioactive phospholipid with mitogenic and/or morphological effects on many cell types. In addition, LPA has been reported to play important roles in various biological processes. It was originally thought that the cellular effects of LPA are mediated by three subtypes of G-protein ...
Satoshi, Ishii +2 more
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Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1
Biochemical and Biophysical Research Communications, 2022Lysophosphatidic acid (LPA) is a bioactive compound known to regulate various vascular functions. However, despite the fact that many vascular functions are regulated by peri-vascular cells such as pericytes, the effect of LPA on brain pericytes has not been fully evaluated. Thus, we designed this study to evaluate the effects of LPA on brain pericytes.
Yoshino Yonezu +3 more
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Analysis of Edg-Like LPA Receptor-Ligand Interactions
Current Pharmaceutical Design, 2015The phospholipid derivative lysophosphatidic acid (LPA) serves as a signalling molecule through the activation of LPA receptors, which belong to the G-protein-coupled receptors. From a pharmacological point of view, the ('EDG-like') LPA1-3 receptors have attracted much attention, therefore we have also been focusing in our study on these subtypes.
Balogh, Balázs +2 more
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Bioorganic & Medicinal Chemistry Letters, 2013
We describe an efficient synthesis of metabolically stabilized sn-2 radyl phosphorothioate analogs of lysophosphatidic acid (LPA), and the determination of the agonist activity of each analog for the six LPA receptors (LPA1-6) using a recently developed TGFα shedding assay.
Guowei, Jiang +3 more
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We describe an efficient synthesis of metabolically stabilized sn-2 radyl phosphorothioate analogs of lysophosphatidic acid (LPA), and the determination of the agonist activity of each analog for the six LPA receptors (LPA1-6) using a recently developed TGFα shedding assay.
Guowei, Jiang +3 more
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Roles of LPA receptor signaling in breast cancer
Expert Review of Molecular Diagnostics, 2016LPA and its receptors play an important role in mediating malignant behaviors in various cancers, including breast cancer. Aberrant expression of certain LPA receptors in breast cancer suggested that LPA receptors could be potential biomarkers in understanding malignant growth patterns of breast cancer. Further research considering molecular mechanisms
Jizhao, Wang +5 more
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