Results 181 to 190 of about 18,471 (244)

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality. [PDF]

Front Immunol
Li X, Li T, Xuan P, Wang H, Yang J.
europepmc   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, Volume 183, Issue 9, Page 1939-1957, May 2026.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Decoding lysophosphatidic acid signaling in physiology and disease: mapping the multimodal and multinodal signaling networks. [PDF]

Signal Transduct Target Ther
Nadhan R, Nath K, Basu S, Isidoro C, Song YS, Dhanasekaran DN.   +5 more
europepmc   +1 more source

Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment. [PDF]

, 2019
HIGUCHI Tomoaki, ICHIMURA Yuki, KATSUMATA Yasuhiro, KAWAGUCHI Yasushi, MASUDA Ikuko, MOROHOSHI Toshiro, NOROSE Takanari, TAKAGI Kae, TOCHIMOTO Akiko, YAMANAKA Hisashi   +9 more
core   +2 more sources

Prospective association of device‐based physical activity and sedentary time during childhood with mental health outcomes during adolescence

Child and Adolescent Mental Health, Volume 31, Issue 2, Page 116-124, May 2026.
Background The present study aimed to analyze associations between device‐measured physical activity and sedentary time during childhood with mental health‐related outcomes throughout adolescence. Methods Data from the Millennium Cohort Study were used.
André O. Werneck, Chih‐Sung Liang, Lee Smith, Dara Aldisi, Nasser Al‐Daghri, Arnold Baca, Liye Zou, Qian Yu, Jin Kuang, Zhihao Zhang, Marco Solmi, Brendon Stubbs   +11 more
wiley   +1 more source

Inhibition of autotaxin sensitizes colon cancer to radiation by suppressing LPAR2-AKT survival signaling. [PDF]

BMC Gastroenterol
Zhang Y, Chen Y, Guo W, Guo Y, Yao S, Wu X.   +5 more
europepmc   +1 more source

Lifelong Exercise as a Modulator of CD4+ T Cell Immunometabolism

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Hypothetical framework illustrating how physical exercise initiated early in life acts as a critical immunomodulatory factor by promoting optimal immune function from childhood and establishing a better “immunometabolic functional peak”. This early advantage may confer sustained benefits to CD4+ T cell metabolism and immune competence across aging ...
Bruna Spolador de Alencar Silva, Amanda Veiga Sardeli, Ricardo R. Agostinete, Helena Batatinha, Alessandra Peres, José César Rosa‐Neto, José Teixeira, Manuel J. Coelho‐e‐Silva, Paulo J. Oliveira, Fábio Santos Lira   +9 more
wiley   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Diabetes Mellitus and Lipoprotein(a): A Determinant Interaction in Micro- and Macrovascular Damage. [PDF]

Int J Mol Sci
Polo-Barranco A, Rebolledo-Maldonado C, Esquiaqui-Rangel V, Nuñez-Mejia A, Rambal-Torres J, Barraza-Ahumada V, Vargas-Cantillo S, Benavides-De la Cruz W, Liñán-Martínez V, Rada-Obeso V, Isaac-Escorcia M, Martínez-Fontalvo N, Correa-Guerrero J, Rodelo-Barrios D, Osorio-Rodríguez E.   +14 more
europepmc   +1 more source