Results 21 to 30 of about 24,569 (245)

Choline chloride attenuates the allergic airway disease by inhibiting the lysophosphatidylcholine induced response in mouse model

Current Research in Pharmacology and Drug Discovery, 2022
Aims: Allergic airway disease manifestation is induced by lysophosphatidylcholine (LPC) through CD1d-restricted Natural killer T (NKT) cells. Choline chloride (ChCl) and LPC both have the “choline” moiety in their structure and this may interplay the ...
Preeti Bansal, Naresh Singh, Jayadev Joshi, Naveen Arora, Shailendera N. Gaur   +4 more
doaj   +1 more source

Lysophosphatidylcholine triggers TLR2- and TLR4-mediated signaling pathways but counteracts LPS-induced NO synthesis in peritoneal macrophages by inhibiting NF-κB translocation and MAPK/ERK phosphorylation. [PDF]

PLoS ONE, 2013
Lysophosphatidylcholine (LPC) is the main phospholipid component of oxidized low-density lipoprotein (oxLDL) and is usually noted as a marker of several human diseases, such as atherosclerosis, cancer and diabetes.
Alan Brito Carneiro, Bruna Maria Ferreira Iaciura, Lilian Lie Nohara, Carla Duque Lopes, Esteban Mauricio Cordero Veas, Vania Sammartino Mariano, Patricia Torres Bozza, Ulisses Gazos Lopes, Georgia Correa Atella, Igor Correia Almeida, Mário Alberto Cardoso Silva-Neto   +10 more
doaj   +1 more source

Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis

Journal of Lipid Research, 2005
Stearoyl lysophosphatidylcholine (LPC) has recently been proven protective against lethal sepsis by stimulating neutrophils to eliminate invading pathogens through an H2O2-dependent mechanism.
Guoqian Chen, Jianhua Li, Xiaoling Qiang, Christopher J. Czura, Mahendar Ochani, Kanta Ochani, Luis Ulloa, Huan Yang, Kevin J. Tracey, Ping Wang, Andrew E. Sama, Haichao Wang   +11 more
doaj   +1 more source

Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length

Respiratory Research, 2010
Background Poor gene transfer efficiency has been a major problem in developing an effective gene therapy for cystic fibrosis (CF) airway disease. Lysophosphatidylcholine (LPC), a natural airway surfactant, can enhance viral gene transfer in animal ...
Anson Don S, Cmielewski Patricia, Parsons David W   +2 more
doaj   +1 more source

Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes

Cells, 2023
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood.
Thomas Timm, Christiane Hild, Gerhard Liebisch, Markus Rickert, Guenter Lochnit, Juergen Steinmeyer   +5 more
doaj   +1 more source

Lysolecithins improved growth performance, nutrient digestibility, immunity, and antioxidant ability in broiler chickens [PDF]

Animal Bioscience
Objective This study investigated the effects of dietary supplementation with lysolecithins (LPC) on growth performance, nutrient digestibility, blood profiles, immunity, and liver health in broiler chickens.
Yuanli Cai, Lu Gao, Bochen Song, Zhigang Song   +3 more
doaj   +1 more source

Comparison of the Diagnostic Performance of C26:0-Lysophosphatidylcholine and Very Long-Chain Fatty Acids Analysis for Peroxisomal Disorders

Frontiers in Cell and Developmental Biology, 2020
Peroxisomes are subcellular organelles that are involved in various important physiological processes such as the oxidation of fatty acids and the biosynthesis of bile acids and plasmalogens.
Yorrick R. J. Jaspers, Sacha Ferdinandusse, Inge M. E. Dijkstra, Rinse Willem Barendsen, Henk van Lenthe, Wim Kulik, Marc Engelen, Susan M. I. Goorden, Frédéric M. Vaz, Stephan Kemp, Stephan Kemp   +10 more
doaj   +1 more source

Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity

Frontiers in Molecular Neuroscience, 2022
Lysophosphatidyl-choline (LPC), a member of the phospholipid family, is an emerging player in pain. It is known to modulate different pain-related ion channels, including Acid-Sensing Ion Channel 3 (ASIC3), a cationic channel mainly expressed in ...
Ludivine Pidoux, Kevin Delanoe, Julie Barbier, Fabien Marchand, Eric Lingueglia, Emmanuel Deval   +5 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

The Action Mode of Lysophosphatidylcholine in Human Monocytes

Journal of Pharmacological Sciences, 2004
To elucidate the action and signal transduction of lysophosphatidylcholine (LPC), we challenged a set of LPC on U937 human monocytes and found that LPC mobilized Ca2+.
Mi-Ran Yun, Fumikazu Okajima, Dong-Soon Im   +2 more
doaj   +1 more source