Results 1 to 10 of about 32,338 (252)

Kinetics of the hydrolysis of phosphatidylcholine and lysophosphatidylcholine

Journal of Pharmacy and Pharmacology, 1969
AbstractAn experimental technique capable of estimating as little as 10 nano-equivalents of long-chain carboxylic acids (fatty acids) has been used to study the decomposition of phospholipids. The rate of release of acids varied with the monovalent cation which was associated with the hydroxyl ion in the hydroxide used.
openaire   +2 more sources

Relationship of lipoprotein-associated phospholipase A2 and oxidized low density lipoprotein in carotid atherosclerosis[S]

Journal of Lipid Research, 2009
Plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and oxidized low density lipoprotein (oxLDL) have been identified as risk factors for cardiovascular disease.
Kasey C. Vickers, Colin T. Maguire, Robert Wolfert, Alan R. Burns, Michael Reardon, Richard Geis, Paul Holvoet, Joel D. Morrisett   +7 more
doaj   +1 more source

Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages

Journal of Lipid Research, 1999
Lysophosphatidylcholine (lysoPC) is a bioactive phospholipid that is involved in atherogenesis and inflammatory processes. However, the present understanding of mechanisms whereby lysophosphatidylcholine exerts its pathophysiological actions is ...
Antonio Gómez-Muñoz, Lori O'Brien, Rajinder Hundal, Urs P. Steinbrecher   +3 more
doaj   +1 more source

Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL

Journal of Lipid Research, 1998
Group IIA secretory phospholipase A2 is an acute phase enzyme, co-expressed with serum amyloid A protein. Both are present in atherosclerotic lesions. We report that human normal and acute phase high density lipoproteins and low density lipoprotein are ...
Waldemar Pruzanski, Eva Stefanski, Frederick C. de Beer, Maria C. de Beer, Peter Vadas, Amir Ravandi, Arnis Kuksis   +6 more
doaj   +1 more source

The grease trap: uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase[S]

Journal of Lipid Research, 2020
Acne is one of the most common dermatological conditions, but the details of its pathology are unclear, and current management regimens often have adverse effects. Cutibacterium acnes is known as a major acne-associated bacterium that derives energy from
Hyo Jung Kim, Bong-Jin Lee, Ae-Ran Kwon
doaj   +1 more source

From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling

Molecules
2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid (EC), acting as a full agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in postsynaptic membranes through the sequential action of phosphoinositide-specific ...
Fabienne Briand-Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan, Jérôme Ausseil, Bernard Payrastre, Jean-Pierre Salles, Hugues Chap   +8 more
doaj   +1 more source

Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC®

Oilseeds and fats, crops and lipids, 2017
Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases.
Bernoud-Hubac Nathalie, Hachem Mayssa, Lo Van Amanda, Picq Madeleine, Lagarde Michel   +4 more
doaj   +1 more source

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate

Journal of Lipid Research, 2015
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development.
Matthew G.K. Benesch, Yuan Y. Zhao, Jonathan M. Curtis, ToddP.W. McMullen, David N. Brindley   +4 more
doaj   +1 more source

The Role of Lysophospholipid Metabolites LPC and LPA in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Metabolites
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent respiratory symptoms and airflow limitation. While there are some available treatment options, the effectiveness of treatment varies depending on ...
Qiqiang Zhou, Yahong Chen, Ying Liang, Yongchang Sun   +3 more
doaj   +1 more source

Hypochlorous acid-mediated generation of glycerophosphocholine from unsaturated plasmalogen glycerophosphocholine lipids

Journal of Lipid Research, 2007
The myeloperoxidase-derived metabolite hypochlorous acid (HOCl) promotes the selective cleavage of plasmalogens into chloro fatty aldehydes and 1-lysophosphatidylcholine (LPC).
Jacqueline Leßig, Jürgen Schiller, Jürgen Arnhold, Beate Fuchs   +3 more
doaj   +1 more source