Results 31 to 40 of about 32,338 (252)

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

Frontiers in Cellular Neuroscience, 2017
Recently, we discovered a cholinergic mechanism that inhibits the adenosine triphosphate (ATP)-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed of α7, α9 and/or α10 subunits ...
Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ, Mike Althaus, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Veronika Grau, Veronika Grau   +17 more
doaj   +1 more source

Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory Mediator Production Through the Protein Kinase A–Phosphatidylinositol 3 Kinase–p38 Mitogen-Activated Protein Kinase Signaling Pathway During Mycobacterium tuberculosis Infection in Mouse Macrophages

Frontiers in Immunology, 2018
Tuberculosis is caused by the infectious agent Mycobacterium tuberculosis (Mtb). Mtb has various survival strategies, including blockade of phagosome maturation and inhibition of antigen presentation. Lysophosphatidylcholine (LPC) is a major phospholipid
Hyo-Ji Lee, Hyo-Ji Lee, Hyun-Jeong Ko, Dong-Kun Song, Yu-Jin Jung   +4 more
doaj   +1 more source

Methods for the preparation of lysophosphatidylcholine

Journal of Pharmacy and Pharmacology, 1971
Abstract The surfactant and solubilizing properties of lysophosphatidylcholine (LPC) could have industrial uses if it became available in technical quantity and purity. The two most promising routes for obtaining it are isolation from cereal starches and mono-deacylation of egg phosphatidylcholine (PC). Baker's yeast autolysed by Letters'
D S, Merryfield, J J, Wren
openaire   +2 more sources

Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits

Journal of Lipid Research, 2002
Lysophosphatidic acid (LPA) is a biologically active phospholipid that has been identified as a vasoactive principle in incubated plasma and serum of mammals.
Akira Tokumura, Yumi Kanaya, Masaki Kitahara, Maki Miyake, Yasuko Yoshioka, Kenji Fukuzawa   +5 more
doaj   +1 more source

The presence of lysophosphatidylcholine in chromaffin granules [PDF]

Biochemical Journal, 1980
Lysophosphatidylcholine is thought to be a characteristic component of the chromaffin granules in adrenal glands. By the use of a t.l.c. system that resolves minor phospholipids satisfactorily, this subcellular location was confirmed in the present study in bovine glands.
G, Arthur, A, Sheltawy
openaire   +2 more sources

ATP Release Drives Inflammation with Lysophosphatidylcholine [PDF]

ImmunoHorizons, 2020
Abstract Lysophosphatidylcholine (LPC), a dominant lipid component of oxidized low-density lipoprotein, plays a major role in inflammation associated with atherosclerosis and neurodegenerative disorders. It activates inflammatory responses from macrophages, neuronal cells, and endothelial cells.
Sana, Ismaeel, Ayub, Qadri
openaire   +3 more sources

Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium–Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity

Frontiers in Pharmacology, 2020
Ulcerative colitis (UC) causes chronic inflammation and damage to the colonic mucosal layer. Recent studies have reported significant changes in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) in UC patients and oral administration of PC has ...
Lixiang Zhai, Tao Huang, Hai-tao Xiao, Pei-gen Wu, Cheng-yuan Lin, Zi-wan Ning, Ling Zhao, Hiu Yee Anna Kwan, Xian-jing Hu, Hoi Leong Xavier Wong, Xian-qian Li, Zhao-xiang Bian, Zhao-xiang Bian   +12 more
doaj   +1 more source

Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: effect of nutritionally induced atherosclerosis

Journal of Lipid Research, 1969
The concentration of lysophosphatidylcholine (monoacyl sn-glycerol 3-phosphorylcholine) in intima plus inner media of atherosclerotic aorta from squirrel monkeys was nearly eight times that in comparable control tissue. Plasma levels of the same compound
Oscar W. Portman, Manfred Alexander
doaj   +1 more source

Total Synthesis of γ-Hydroxy-α,β-Unsaturated Aldehydic Esters of Cholesterol and 2-Lysophosphatidylcholine

, 2016
Free radical-induced oxidation of polyunsaturated fatty esters in low-density lipoproteins (LDLs) generates 2-lysophosphatidylcholine (PC) and cholesterol esters of γ-hydroxy-α,β-unsaturated aldehydic acids that covalently modify LDL protein, and protein
Yijun Deng (1264830), Robert G. Salomon (465209)   +1 more
core   +1 more source

A specific serum lipid signature characterizes patients with glycogen storage disease type Ia

Journal of Lipid Research
Glycogen storage disease type Ia (GSDIa) is a rare, inherited glucose-6-phosphatase-α (G6Pase-α) deficiency-induced carbohydrate metabolism disorder.
Alessandro Rossi, Margherita Ruoppolo, Roberta Fedele, Francesca Pirozzi, Carmen Rosano, Renata Auricchio, Daniela Melis, Pietro Strisciuglio, Maaike H. Oosterveer, Terry G.J. Derks, Giancarlo Parenti, Marianna Caterino   +11 more
doaj   +1 more source