Results 41 to 50 of about 39,809 (251)

A specific serum lipid signature characterizes patients with glycogen storage disease type Ia

Journal of Lipid Research
Glycogen storage disease type Ia (GSDIa) is a rare, inherited glucose-6-phosphatase-α (G6Pase-α) deficiency-induced carbohydrate metabolism disorder.
Alessandro Rossi, Margherita Ruoppolo, Roberta Fedele, Francesca Pirozzi, Carmen Rosano, Renata Auricchio, Daniela Melis, Pietro Strisciuglio, Maaike H. Oosterveer, Terry G.J. Derks, Giancarlo Parenti, Marianna Caterino   +11 more
doaj   +1 more source

Lysophosphatidylcholine (17:0) Improves HFD-Induced Hyperglycemia & Insulin Resistance: A Mechanistic Mice Model Study

Diabetes, Metabolic Syndrome and Obesity, 2022
Li Bao,1,2 Ying Zhang,2,3 Sichao Yan,1,2 Dan Yan,2,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Bio-Characteristic Profiling for ...
Bao L, Zhang Y, Yan S, Yan D, Jiang D
doaj  

Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice

Biomedicines, 2022
Glucotoxic metabolites and pathways play a crucial role in diabetic complications, and new treatment options which improve glucotoxicity are highly warranted. In this study, we analyzed bezafibrate (BEZ) treated, streptozotocin (STZ) injected mice, which
Andras Franko, Martin Irmler, Cornelia Prehn, Silke S. Heinzmann, Philippe Schmitt-Kopplin, Jerzy Adamski, Johannes Beckers, Jürgen-Christoph von Kleist-Retzow, Rudolf Wiesner, Hans-Ulrich Häring, Martin Heni, Andreas L. Birkenfeld, Martin Hrabě de Angelis   +12 more
doaj   +1 more source

Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection

Journal of Lipid Research, 2023
Pathogenic mechanisms in degenerative thoracic aortic aneurysms (TAA) are still unclear. There is an ongoing debate about whether TAAs are caused by uniform or distinct processes, which would obviously have a major impact on future treatment strategies ...
Christian Doppler, Barbara Messner, Teresa Mimler, Bruno Schachner, Marlene Rezk, Clara Ganhör, Christian Wechselberger, Marina Müller, Spela Puh, Johannes Pröll, Barbara Arbeithuber, Thomas Müller, Andreas Zierer, David Bernhard   +13 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2007
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Mittelstrass, Kirstin, Ried, Janina S., Yu, Zhonghao, Krumsiek, Jan, Gieger, Christian, Prehn, Cornelia, Roemisch-Margl, Werner, Polonikov, Alexey, Peters, Annette, Theis, Fabian J., Meitinger, Thomas, Kronenberg, Florian, Weidinger, Stephan, Wichmann, Heinz-Erich, Suhre, Karsten, Wang-Sattler, Rui, Adamski, Jerzy, Illig, Thomas   +17 more
core   +2 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

混合フォスファチジルコリン水溶液におけるひも状ミセル構造の形成 [PDF]

, 2015
東京海洋大学博士学位論文 平成26年度(2014) 応用生命科学 課程博士 甲第339号指導教員: 松川真吾全文公表年月日: 2014-12 ...
Fafaungwithayakul Natdanai
core   +1 more source

Metabolic Modulation Predicts Heart Failure Tests Performance [PDF]

, 2019
The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook metabolomic and lipidomic phenotyping of a cohort of heart failure (HF) patients and utilized Multiple ...
Abbate, Antonio, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Contaifer, Daniel, Jr., Kumar, Naren G., Morriss, Joshua M., Ranasinghe, Asanga D., Trankle, Cory, Van Tassell, Benjamin W., Wijesinghe, Dayanjan S., Wohlford, George   +11 more
core   +3 more sources

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2012
Isolated hepatocytes undergo lipoapoptosis, a feature of hepatic lipotoxicity, on treatment with saturated free fatty acids (FFA) such as palmitate (PA). However, it is unknown if palmitate is directly toxic to hepatocytes or if its toxicity is indirect via the generation of lipid metabolites such as lysophosphatidylcholine (LPC).
Keisuke, Kakisaka, Sophie C, Cazanave, Christian D, Fingas, Maria E, Guicciardi, Steven F, Bronk, Nathan W, Werneburg, Justin L, Mott, Gregory J, Gores   +7 more
openaire   +2 more sources