Results 41 to 50 of about 32,338 (252)
Diabetes, Metabolic Syndrome and Obesity, 2022 Li Bao,1,2 Ying Zhang,2,3 Sichao Yan,1,2 Dan Yan,2,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Bio-Characteristic Profiling for ...
Bao L, Zhang Y, Yan S, Yan D, Jiang D
doaj
Lysophosphatidylcholine export by human ABCA7
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017 The ATP-binding cassette transporter A7 (ABCA7), which is highly expressed in the brain, is associated with the pathogenesis of Alzheimer's disease (AD). However, the physiological function of ABCA7 and its transport substrates remain unclear. Immunohistochemical analyses of human brain sections from AD and non-AD subjects revealed that ABCA7 is ...
Maiko, Tomioka +8 more
openaire +3 more sources
Journal of Lipid Research, 1998 To determine the respective roles of endothelial cells from brain capillaries and astrocytes in the conversion of circulating 18:2n–6 and 18:3n–3 into 20:4n–6 and 22:6n–3, respectively, a coculture of the two cell types mimicking the in vivo blood–brain ...
N. Bernoud +8 more
doaj +1 more source
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes [PDF]
Journal of Lipid Research, 2008 The pathogenesis of nonalcoholic steatohepatitis (NASH) is unclear, despite epidemiological data implicating FFAs. We studied the pathogenesis of NASH using lipoapoptosis models. Palmitic acid (PA) induced classical apoptosis of hepatocytes. PA-induced lipoapoptosis was inhibited by acyl-CoA synthetase inhibitor but not by ceramide synthesis inhibitors,
Myoung Sook Han +15 more
openaire +4 more sources
Lysophosphatidylcholine accumulation in the ischemic canine heart
, 1988 The production of cardiac arrhythmias and the elevation of lysophosphatidylcholine level in the ischemic myocardium have been well-documented in a number of studies. However, the relationship between the production arrhythmias and the elevation of tissue
Man, RYK, Kinnaird, AAA, Choy, PC
core +1 more source
, 2016 A total synthesis of (11E)-9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine (HOT-PC) was devised to facilitate identification of this oxidized phospholipid. A lactone, 8-(3-oxo-1H,6H-2-oxinyl)octanoic acid (1), believed to be generated
Yijun Deng (1264830) +1 more
core +1 more source
Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice
Biomedicines, 2022 Glucotoxic metabolites and pathways play a crucial role in diabetic complications, and new treatment options which improve glucotoxicity are highly warranted. In this study, we analyzed bezafibrate (BEZ) treated, streptozotocin (STZ) injected mice, which
Andras Franko +12 more
doaj +1 more source
Advanced Science, EarlyView.Ti‐doped Zr/Ti bimetallic MOFs activate neighboring Zr sites to selectively capture phospholipids from serum through cooperative interactions. In nontargeted screening, the material minimizes matrix interference, expands detectable feature coverage, and enables broad recovery of diverse chemical hazards, providing a powerful cleanup strategy for LC ...
Yanmin Liang +5 more
wiley +1 more source
Journal of Lipid Research, 2023 Pathogenic mechanisms in degenerative thoracic aortic aneurysms (TAA) are still unclear. There is an ongoing debate about whether TAAs are caused by uniform or distinct processes, which would obviously have a major impact on future treatment strategies ...
Christian Doppler +13 more
doaj +1 more source
The association of lysophosphatidylcholine with isolated cardiac myocytes
, 1990 The ability of exogenous lysophosphatidylcholine to produce electrophysiological derangements and cardiac arrhythmias in the heart has been documented.
Man, RYK +3 more
core +1 more source