Results 21 to 30 of about 32,338 (252)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Dantrolene inhibits lysophosphatidylcholine-induced valve interstitial cell calcific nodule formation via blockade of the ryanodine receptor

Frontiers in Cardiovascular Medicine, 2023
Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is
Christopher B. Sylvester, Christopher B. Sylvester, Farshad Amirkhosravi, Farshad Amirkhosravi, Angelina S. Bortoletto, Angelina S. Bortoletto, William J. West, William J. West, Jennifer P. Connell, K. Jane Grande-Allen   +9 more
doaj   +1 more source

Effects of Lysophosphatidylcholine on Jejuna Morphology and Its Potential Mechanism

Frontiers in Veterinary Science, 2022
Lysophosphatidylcholine (LPC) plays a vital role in promoting jejuna morphology in broilers. However, the potential mechanism behind LPC improving the chicken jejuna morphology is unclear. Therefore, the present study was designed to reveal the important
Xiaofeng Li, Abdel-Moneim Eid Abdel-Moneim, Noura M. Mesalam, Bing Yang   +3 more
doaj   +1 more source

Phospholipases and Reactive Oxygen Species Derived Lipid Biomarkers in Healthy and Diseased Humans and Animals – A Focus on Lysophosphatidylcholine

Frontiers in Physiology, 2021
Phospholipids (PL) are converted into lipid biomarkers by the action of phospholipases and reactive oxygen species (ROS), which are activated or released under certain physiological and pathophysiological conditions.
Kathrin M. Engel, Jürgen Schiller, Christina E. Galuska, Beate Fuchs   +3 more
doaj   +1 more source

A metabolomic investigation of the effects of vitamin E supplementation in humans [PDF]

, 2012
Background Vitamin E is a nutrient with both antioxidant and non-antioxidant activities and has been shown to modulate the function of a number of cell types in vitro and in human studies.
John K Lodge, Max Wong, Lodge John K, Lodge, John, Wong, Max, Wong Max   +5 more
core   +3 more sources

Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids

Journal of Lipid Research, 2001
Lysophosphatidylcholine is an abundant component of plasma and oxidized LDL that displays several biological activities, some of which may occur through the platelet-activating factor (PAF) receptor.
Gopal K. Marathe, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre   +6 more
doaj   +1 more source

The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism

Biomolecules, 2023
The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent ...
Sayaka Harada, Yoshitaka Taketomi, Toshiki Aiba, Mai Kawaguchi, Tetsuya Hirabayashi, Baasanjav Uranbileg, Makoto Kurano, Yutaka Yatomi, Makoto Murakami   +8 more
doaj   +1 more source

Preserved and variable spatial‐chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade

Plant-Environment Interactions, 2021
Membrane lipids serve as substrates for the generation of numerous signaling lipids when plants are exposed to environmental stresses, and jasmonic acid, an oxidized product of 18‐carbon unsaturated fatty acids (e.g., linolenic acid), has been recognized
Dušan Veličković, Rosalie K. Chu, Corinna Henkel, Annika Nyhuis, Nannan Tao, Jennifer E. Kyle, Joshua N. Adkins, Christopher R. Anderton, Vanessa Paurus, Kent Bloodsworth, Lisa M. Bramer, Dale S. Cornett, Wayne R. Curtis, Kristin E. Burnum‐Johnson   +13 more
doaj   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

Frontiers in Immunology, 2020
Foam cells are specialized lipid-loaded macrophages derived from monocytes and are a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a major lipid component of the plasma membrane with a broad spectrum of ...
Rafael Corrêa, Luís Felipe Fonseca Silva, Dalila Juliana Silva Ribeiro, Raquel das Neves Almeida, Igor de Oliveira Santos, Luís Henrique Corrêa, Lívia Pimentel de Sant'Ana, Leonardo Santos Assunção, Patrícia T. Bozza, Kelly Grace Magalhães   +9 more
doaj   +1 more source