Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery
Frontiers in Neurology, 2022 Stroke is a serious global public health issue, associated with severe disability and high mortality rates. Its early detection is challenging, and no effective biomarkers are available.
Meiling Huang +8 more
doaj +3 more sources
Weizmannia coagulans BC99 Ameliorates Obesity and Associated Inflammation by Remodeling the Gut Microbiota and Regulating Lysophosphatidylcholine and Conjugated Bile Acid Metabolism [PDF]
MetabolitesBackground: Obesity is closely related to dysbiosis. Probiotics may improve metabolism and alleviate inflammation by regulating microbial–host interaction. Methods: Obesity was induced in rats by feeding a high-fat diet, followed by gavage administration
Yujia Pan +9 more
doaj +2 more sources
Identification of plasma lipid metabolism and potential biomarkers in patients with different coronary occlusive acute myocardial infarction [PDF]
Frontiers in Cell and Developmental BiologyAcute myocardial infarction (AMI) is the main cause of death worldwide. We aim to compare the differences in plasma lipid metabolites between AMI patients and normal controls to search for biomarker molecules for AMI with different infarct sites.
Hao Chen +4 more
doaj +2 more sources
Untargeted Metabolomics Reveals Metabolic Reprogramming Linked to HCC Risk in Late Diagnosed Tyrosinemia Type 1 [PDF]
MetabolitesBackground/Objectives: Tyrosinemia type 1 (HT-1) is a treatable inherited disorder characterized by disrupted tyrosine metabolism, leading to severe liver, renal, and occasionally neurological dysfunction.
Anna Sidorina +10 more
doaj +2 more sources
Practical Laboratory Medicine, 2023 Background and objectives: Very long-chain fatty acyl-lysophosphatidylcholines (VLCFA-LysoPCs) are measured in dried blood spots (DBS) for identifying X-linked adrenoleukodystrophy (X-ALD) and other inherited peroxisomal disorders.
Archana Natarajan, Rita Christopher
doaj +3 more sources
Microbiology SpectrumGut microbiota have been found to promote hypoxia-induced intestinal injury. However, the role of gut microbiota in high-altitude pulmonary edema (HAPE), the preventive effect of synbiotic on HAPE, and the mechanisms by which they might work remain ...
Xianduo Sun +9 more
doaj +3 more sources
Lipid profiling of Parkinson’s disease brain highlights disruption in Lysophosphatidylcholines, and triacylglycerol metabolism [PDF]
npj Parkinson's DiseaseParkinson’s disease (PD) is the second most common neurodegenerative disorder following Alzheimer’s disease, with a 1.5 times higher prevalence in males.
Ali Yilmaz +8 more
doaj +2 more sources
Metabolic profiles of squamous cell lung carcinoma and diagnostic model construction [PDF]
Scientific ReportsCancer cells exhibit metabolic reprogramming to fulfill their increased demands for abnormal growth and proliferation. We studied metabolic profiles of squamous cell lung carcinoma (LUSC).
Kyung Soo Kim +5 more
doaj +2 more sources
Synthesis of Lysophosphatidylcholine and Mixed Phosphatidylcholine [PDF]
The Journal of Organic Chemistry, 2022 Lysophosphatidylcholine (LPC) and phosphatidylcholine (PC) are important membrane constituents implicated in signaling and immune regulation. Synthesis of LPCs is challenging due to rapid acyl migration, e.g., induced by chromatography. We here report a highly regioselective synthesis of LPC and mixed PC via an intermediate allowing specific terminal ...
Athanasios Papangelis, Trond Ulven
openaire +3 more sources
Frontiers in Endocrinology, 2023 AimsThis study aimed to explore associations of mannan-binding lectin-associated serine protease (MASP) levels in early pregnancy with gestational diabetes mellitus (GDM).
Ming Gao +16 more
doaj +1 more source