Results 11 to 20 of about 5,247 (197)

Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection

Frontiers in Cardiovascular Medicine, 2021
Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD.
Huang Huang, Guozhu Ye, Song-qing Lai, Hua-xi Zou, Bin Yuan, Qi-cai Wu, Li Wan, Qun Wang, Xue-liang Zhou, Wen-jun Wang, Yuan-ping Cao, Jian-feng Huang, Shi-li Chen, Bi-cheng Yang, Ji-chun Liu   +14 more
doaj   +1 more source

Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women

Metabolites, 2021
The use of oral contraceptives (OCs) has been associated with elevated blood cortisol concentrations. However, metabolic downstream effects of OC intake are not well described.
Clara Eick, Johanna Klinger-König, Stephanie Zylla, Anke Hannemann, Kathrin Budde, Ann Kristin Henning, Maik Pietzner, Matthias Nauck, Henry Völzke, Hans J. Grabe, Johannes Hertel   +10 more
doaj   +1 more source

The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia

Journal of Lipid Research, 2021
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are involved in the development of this condition, and even less is known how these ...
Bing He, Yu Liu, Mano R. Maurya, Paula Benny, Cameron Lassiter, Hui Li, Shankar Subramaniam, Lana X. Garmire   +7 more
doaj   +1 more source

Metabolic Profiling of Plasma in Different Calving Body Condition Score Cows Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomics Approach

Animals, 2020
This study was undertaken to identify metabolite differences in plasma of dairy cows with a normal or high calving body condition score (CBCS), using untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics.
Jian Wang, Chuang Zhang, Qingyao Zhao, Congcong Li, Shuang Jin, Xianhong Gu   +5 more
doaj   +1 more source

Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa.

PLoS ONE, 2022
Decline of ovarian function in menopausal women increases metabolic disease risk. Curcuma comosa extract and its major compound, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DPHD), improved estrogen-deficient ovariectomized (OVX) rat metabolic ...
Jetjamnong Sueajai, Nareerat Sutjarit, Nittaya Boonmuen, Saranya Auparakkitanon, Nantida Noumjad, Apichart Suksamrarn, Nawaporn Vinayavekhin, Pawinee Piyachaturawat   +7 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles

Metabolites, 2022
Fetal tobacco exposure has persistent effects on growth and metabolism. The underlying mechanisms of these relationships are yet unknown. We investigated the associations of fetal exposure to maternal smoking with neonatal metabolite profiles.
Kim N. Cajachagua-Torres, Sophia M. Blaauwendraad, Hanan El Marroun, Hans Demmelmair, Berthold Koletzko, Romy Gaillard, Vincent W. V. Jaddoe   +6 more
doaj   +1 more source

Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication⋆

JHEP Reports, 2021
Background & Aims: In experimental models, alcohol induces acute changes in lipid metabolism that cause hepatocyte lipoapoptosis and inflammation. Here we study human hepatic lipid turnover during controlled alcohol intoxication.
Mads Israelsen, Min Kim, Tommi Suvitaival, Bjørn Stæhr Madsen, Camilla Dalby Hansen, Nikolaj Torp, Kajetan Trost, Maja Thiele, Torben Hansen, Cristina Legido-Quigley, Aleksander Krag   +10 more
doaj   +1 more source

Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes

Annals of Clinical and Translational Neurology, 2022
Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who ...
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman   +11 more
doaj   +1 more source

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

Marine Drugs, 2020
Microalgae have been shown to be excellent producers of lipids, pigments, carbohydrates, and a plethora of secondary metabolites with possible applications in the pharmacological, nutraceutical, and cosmeceutical sectors. Recently, various microalgal raw
Chiara Lauritano, Kirsti Helland, Gennaro Riccio, Jeanette H. Andersen, Adrianna Ianora, Espen H. Hansen   +5 more
doaj   +1 more source