Results 11 to 20 of about 7,630 (250)
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
ATP Release Drives Inflammation with Lysophosphatidylcholine [PDF]
ImmunoHorizons, 2020 Abstract Lysophosphatidylcholine (LPC), a dominant lipid component of oxidized low-density lipoprotein, plays a major role in inflammation associated with atherosclerosis and neurodegenerative disorders. It activates inflammatory responses from macrophages, neuronal cells, and endothelial cells.
Sana, Ismaeel, Ayub, Qadri
openaire +3 more sources
The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia
Journal of Lipid Research, 2021 Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are involved in the development of this condition, and even less is known how these ...
Bing He +7 more
doaj +1 more source
Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
core +2 more sources
Animals, 2020 This study was undertaken to identify metabolite differences in plasma of dairy cows with a normal or high calving body condition score (CBCS), using untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics.
Jian Wang +5 more
doaj +1 more source
Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa.
PLoS ONE, 2022 Decline of ovarian function in menopausal women increases metabolic disease risk. Curcuma comosa extract and its major compound, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DPHD), improved estrogen-deficient ovariectomized (OVX) rat metabolic ...
Jetjamnong Sueajai +7 more
doaj +1 more source
Synthesis of Lysophosphatidylcholine and Mixed Phosphatidylcholine [PDF]
The Journal of Organic Chemistry, 2022 Lysophosphatidylcholine (LPC) and phosphatidylcholine (PC) are important membrane constituents implicated in signaling and immune regulation. Synthesis of LPCs is challenging due to rapid acyl migration, e.g., induced by chromatography. We here report a highly regioselective synthesis of LPC and mixed PC via an intermediate allowing specific terminal ...
Athanasios Papangelis, Trond Ulven
openaire +3 more sources
Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles
Metabolites, 2022 Fetal tobacco exposure has persistent effects on growth and metabolism. The underlying mechanisms of these relationships are yet unknown. We investigated the associations of fetal exposure to maternal smoking with neonatal metabolite profiles.
Kim N. Cajachagua-Torres +6 more
doaj +1 more source
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes [PDF]
, 2012 BACKGROUND: Obesity and type 2 diabetes (T2DM) are associated with increased circulating free fatty acids and triacylglycerols. However, very little is known about specific molecular lipid species associated with these diseases.
AD Karelis +36 more
core +3 more sources
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response [PDF]
, 2019 Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C.
Baugh, Lauren +5 more
core +1 more source