Results 21 to 30 of about 7,630 (250)

Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]

, 2020
Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian, Bahethi, Rohini, Beule, Dieter, Choi, Murim, Eisenhofer, Graeme, Liebisch, Gerhard, Messerschmidt, Clemens, Obermayer, Benedikt, Peitzsch, Mirko, Scholl, Ute I., Schrade, Petra, Seidel, Eric, Walenda, Gudrun, Wallace, Paal, Yoo, Taekyeong   +14 more
core   +2 more sources

Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication⋆

JHEP Reports, 2021
Background & Aims: In experimental models, alcohol induces acute changes in lipid metabolism that cause hepatocyte lipoapoptosis and inflammation. Here we study human hepatic lipid turnover during controlled alcohol intoxication.
Mads Israelsen, Min Kim, Tommi Suvitaival, Bjørn Stæhr Madsen, Camilla Dalby Hansen, Nikolaj Torp, Kajetan Trost, Maja Thiele, Torben Hansen, Cristina Legido-Quigley, Aleksander Krag   +10 more
doaj   +1 more source

Lipidomic analysis of plasma samples from women with polycystic ovary syndrome [PDF]

, 2015
Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagnostic.
A Dunaif, AD Postle, B Banaszewska, B Matharoo-Ball, BC Choi, C Hughes, Catharine A. Ortori, Charlie Hodgman, Clare Daykin, David A. Barrett, Dov J. Stekel, J Friedman, JK Reddy, JY Kim, L Sun, M Insenser, M Luque-Ramirez, M Urbanek, MR Wenk, MS Bloom, NG Woods, Nick Raine-Fenning, O Quehenberger, PG Munder, PJ Meikle, R Kolesnick, R Pasquali, R Punnonen, RA Wild, Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, RS Legro, Srinivasarao Ravipati, W Atiomo, WA March, William Atiomo, WU Atiomo, X Han, X Ma, Y Zhao, Zeina Haoula, ZJ Chen   +40 more
core   +1 more source

Metabolomic profiling of women with gestational diabetes mellitus and their offspring: Review of metabolomics studies. [PDF]

, 2018
BACKGROUND:Gestational diabetes mellitus (GDM) reflects an increased risk of developing type 2 diabetes (T2D) after pregnancy in women. Offspring born to mothers with GDM are at an elevated risk of obesity and T2D at a young age.
Chen, Liwei, Chen, Qian, Francis, Ellen, Hu, Gang   +3 more
core   +1 more source

Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats [PDF]

, 2016
Supplementary tables. Table S1. Class, m/z, retention time, ion of detected and identified lipid molecules, and determined their fatty side chains. Table S2. Normalized levels of lipid molecules in individual samples. Table S3. Fold change and p-value of
Hiroshi Yamada, Keiko Maekawa, Kosuke Saito, Masaki Ishikawa, Noriyuki Nakatsu, Yoshiro Saito   +5 more
core   +2 more sources

Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes

Annals of Clinical and Translational Neurology, 2022
Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who ...
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman   +11 more
doaj   +1 more source

Metabolic characterization of the natural progression of chronic hepatitis B [PDF]

, 2016
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases.
Berger, R. (Ruud), Boonstra, P.A. (André), Hankemeier, T. (Thomas), Harms, A.C. (Amy), Hou, J. (Jun), Schoeman, J.C. (Johannes C.), Vreeken, R. (Rob)   +6 more
core   +1 more source

Lysophosphatidylcholines and Chlorophyll-Derived Molecules from the Diatom Cylindrotheca closterium with Anti-Inflammatory Activity

Marine Drugs, 2020
Microalgae have been shown to be excellent producers of lipids, pigments, carbohydrates, and a plethora of secondary metabolites with possible applications in the pharmacological, nutraceutical, and cosmeceutical sectors. Recently, various microalgal raw
Chiara Lauritano, Kirsti Helland, Gennaro Riccio, Jeanette H. Andersen, Adrianna Ianora, Espen H. Hansen   +5 more
doaj   +1 more source

Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan. [PDF]

Aging Cell
Losartan partially reversed serum metabolomic aging signatures in both aged mice and pre‐frail older men, and this effect required functional angiotensin II receptors in mice. Cross‐species analyses suggest aging shifts circulating metabolites in opposite directions in mice versus humans, particularly among lipids, with losartan partially normalizing ...
Bene MR, Zhang C, Westbrook R, Gabrawy M, Marx R, Wu Y, Khadeer M, Ubaida-Mohien C, Ferrucci L, Moaddel R, Le A, Walston JD, Lee JL, Abadir PM.   +13 more
europepmc   +2 more sources

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis [PDF]

, 2015
Peer reviewedPublisher ...
Alibu, Vincent Pius, Gomez-Romero, Maria, Holmes, Elaine, Lamour, Sabrina D, Saric, Jasmina, Sternberg, Jeremy M, Vorkas, Pangiotis A   +6 more
core   +4 more sources