Results 41 to 50 of about 6,447 (173)

Metabolic profiling reveals interleukin-17A monoclonal antibody treatment ameliorate lipids metabolism with the potentiality to reduce cardiovascular risk in psoriasis patients

Lipids in Health and Disease, 2021
Background Psoriasis is a common chronic inflammatory skin disease associated with overproduction of interleukin-17A (IL-17A). IL-17A monoclonal antibodies (mAbs) have shown clinical efficacy in psoriasis patients.
Han Cao, Shengmin Su, Qi Yang, Yunchen Le, Lihong Chen, Mengyan Hu, Xiaoyu Guo, Jie Zheng, Xia Li, Yunqiu Yu   +9 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Lanthanide-induced phosphorus-31 NMR downfield chemical shifts of lysophosphatidylcholines are sensitive to lysophospholipid critical micelle concentration [PDF]

, 1991
Lysophosphatidylcholine (lysoPC) monomers or micelles in water give rise to a narrow, isotropic phosphorus-31 NMR signal (40.6 ppm; v1/2 1.7 Hz; 32.2 MHz). Upon addition of praseodymium ions, the phosphorus signals are shifted downfield.
Kumar, V.V., Baumann, W.J.
core   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis

iScience, 2023
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available.
Upasana Parthasarathy, Yi Kuang, Gunjan Thakur, John D. Hogan, Thomas P. Wyche, James E. Norton, Jr., Jason R. Killough, Theodore R. Sana, Caroline Beakes, BaoJen Shyong, Rena N. Zhang, Dario A. Gutierrez, Michael Filbin, David C. Christiani, Alex G. Therien, Christopher H. Woelk, Cory H. White, Roberta Martinelli   +17 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Application of a diagnostic methodology by quantification of 26:0 lysophosphatidylcholine in dried blood spots for Japanese newborn screening of X-linked adrenoleukodystrophy

Molecular Genetics and Metabolism Reports, 2017
X-linked adrenoleukodystrophy (X-ALD) is a rare inherited metabolic disease that results in the accumulation of very long chain fatty acids (VLCFA) in plasma and all tissues.
Chen Wu, Takeo Iwamoto, Junko Igarashi, Takashi Miyajima, Mohammad Arif Hossain, Hiroko Yanagisawa, Keiko Akiyama, Haruo Shintaku, Yoshikatsu Eto   +8 more
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children [PDF]

, 2022
Background: The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes.
Hyötyläinen T., Madden S., Lewis G., Orešič M., Cotter D., Madrid-Gambin F., Föcking M., Cannon M., Heurich M., English J., Brennan L., Zammit S., Scaife C., Mattila I., O'Gorman A., Cagney G., Ahonen L., Sabherwal S., Suvitaival T.   +18 more
core   +1 more source

Processing of lysophosphatidylcholines by ExoU secreted by

Cell Reports
Summary: Pseudomonas aeruginosa ( P. aeruginosa ) thrives in the lungs of patients with cystic fibrosis (CF) which results in pulmonary inflammation and decline in lung function.
Melissa Sen Phuong, Adam Mahdi, David Cai, Katie Noah, Dikchha Rijal, Rachel Kaul, Avni Bhan, Sahil Yadav, Ardeshir Ariana, Rayan El Hamra, Wangxue Chen, Rees Kassen, Rafael Hernandez, Alex Wong, Dara W. Frank, Gerald B. Pier, Zhenyu Cheng, Miroslava Cuperlovic-Culf, Steffany A.L. Bennett, Subash Sad   +19 more
doaj   +1 more source