Results 51 to 60 of about 6,447 (173)

A four parameter optimization and troubleshooting of a RPLC – charged aerosol detection stability indicating method for determination of S-lysophosphatidylcholines in a phospholipid formulation

, 2018
A four parameter optimization of a stability indicating method for non-chromophoric degradation products of 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC), 1-Stearoyl-sn-glycero-3-phosphocholine and 2-stearoyl-sn-glycero-3-phosphocholine was achieved
Blasko, Andrei, Ahmed, Imad Haidar, Andrei Blasko, Imad A. Haidar Ahmad, James Tam, Tam, Yat Kong   +5 more
core   +1 more source

Impact of Drone Versus Car Transport on Anti‐Doping Sample Integrity Over Short Distances: A Proof‐Of‐Concept Study

Drug Testing and Analysis, EarlyView.
This proof‐of‐concept study evaluated the impact of short‐distance drone transport on anti‐doping sample integrity compared with traditional car transport. Targeted assays and untargeted metabolomics revealed equivalent biological profiles between methods, confirming that drone delivery preserves sample integrity for the athlete biological passport ...
I. Al‐Mohannadi, M. Y. Al‐Jaber, M. Al‐Nesf, W. Samsam, Abdulaziz Farooq, N. M. Thomas, M. Stuart, N. Robinson, G. Zangenfeind, D. Rovira, N. Mohamed‐Ali, A. Beotra, V. Mohamed‐Ali, M. Al‐Maadheed   +13 more
wiley   +1 more source

Schwann cell-derived Apolipoprotein D controls the dynamics of post-injury myelin recognition and degradation

Frontiers in Cellular Neuroscience, 2014
Management of lipids, particularly signaling lipids that control neuroinflammation, is crucial for the regeneration capability of a damaged nervous system.
Nadia eGarcía-Mateo, Maria Dolores Ganfornina, Olimpio eMontero, Miguel A Gijón, Robert eMurphy, Diego eSanchez   +5 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

Antioxidants, 2021
Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C ...
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui   +3 more
doaj   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC.

PLoS ONE, 2015
ObjectiveAlthough metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations.
Marion Carayol, Idlir Licaj, David Achaintre, Carlotta Sacerdote, Paolo Vineis, Timothy J Key, N Charlotte Onland Moret, Augustin Scalbert, Sabina Rinaldi, Pietro Ferrari   +9 more
doaj   +1 more source

Seed lipid profiles of perennial ryegrass: Global patterns and differentiation of ryegrass cultivars and Epichloë endophytes

Grassland Research, EarlyView.
Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao, Wei Zhang, Wade J. Mace, Christine R. Voisey, David E. Hume, Richard D. Johnson, Sushma Prakash   +6 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology
Glioblastoma (GB) is the most aggressive primary brain tumor with poor prognosis despite multimodal therapy. Calorie‐restricted diets have emerged as putative strategies to augment anticancer therapies. We employed UHPLC‐high‐resolution mass spectrometry
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
doaj   +1 more source

Valproic Acid Treatment after Traumatic Brain Injury in Mice Alleviates Neuronal Death and Inflammation in Association with Increased Plasma Lysophosphatidylcholines [PDF]

The histone deacetylase inhibitor (HDACi) valproic acid (VPA) has neuroprotective and anti-inflammatory effects in experimental traumatic brain injury (TBI), which have been partially attributed to the epigenetic disinhibition of the transcription ...
Robert Gurke, Ritter, Katharina, Michael K. E. Schäfer, Zander, Sonja, Irmgard Tegeder, Dorochow, Erika, Hahnefeld, Lisa, Tegeder, Irmgard, Lisa Hahnefeld, Erika Dorochow, Katharina Ritter, Hummel, Regina, Gurke, Robert, Regina Hummel, Sonja Zander, Schäfer, Michael K. E.   +15 more
core   +2 more sources