Results 71 to 80 of about 6,447 (173)

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

Synthesis of lysophosphatidylcholines synthetic studies toward the total synthesis of epi-mauritine d:macrocyclization

, 2001
본 논문은 part I와 part II 두 부분으로 구성되어져 있는데 part I는 lysophosphatidyldhoines의 합성에 관한 내용이며, part II는 시클로펩티드 알칼로이드인 epi-mauritine D의 전합성에 관한 내용이다. Part I 에서는 생리활성에서 중요한 역할을 자기는 phospholipids중 lysophosphatidylcholine 을 합성하였다.
박명순
core   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Formation of βTC3 and MIN6 Pseudoislets Changes the Expression Pattern of Gpr40, Gpr55, and Gpr119 Receptors and Improves Lysophosphatidylcholines-Potentiated Glucose-Stimulated Insulin Secretion

, 2020
The impaired spatial arrangement and connections between cells creating islets of Langerhans as well as altered expression of G protein-coupled receptors (GPCRs) often lead to dysfunction of insulin-secreting pancreatic β cells and can significantly
Edyta Gendaszewska-Darmach, Eliza Cichońska, Maria Koziołkiewicz, Anna Drzazga   +3 more
core   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source

Direct infusion mass spectrometry serum lysophosphatidylcholines (LPC) (μM) from 14 lean (L-MAINT) and 16 obese (O-MAINT) cats during weight maintenance and during 10-week energy restriction (O-RESTRICT).

Direct infusion mass spectrometry serum lysophosphatidylcholines (LPC) (μM) from 14 lean (L-MAINT) and 16 obese (O-MAINT) cats during weight maintenance and during 10-week energy restriction (O-RESTRICT).
Shauna L. Blois (13977867), Myriam Hesta (728984), Moran Tal (18165187), Marica Bakovic (722729), Anna K. Shoveller (6208457), Adronie Verbrugghe (3485333), Hannah Godfrey (12256593), Caitlin E. Grant (12256599)   +7 more
core   +1 more source

Plasma lipid metabolites as biomarkers of early white matter degeneration in Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Alzheimer's disease (AD) is characterized by progressive white matter (WM) degeneration. Circulating lipid metabolites may serve as early indicators of WM microstructural changes.
Alireza Shaabanpoor Haghighi, Hamide Nasiri, Arman Ghayourvahdat, Hannaneh Azimizonuzi, Negar Ghasemi, Meysam Mansouri, Arya Moftakhar Bazkiaei, Mohammad Amir Amirian, Sevda Zeinali, Hamed Gozali, Rezvaneh Rostami, Maryam Ayobi, Alzheimer's Disease Neuroimaging Initiative   +12 more
doaj   +1 more source

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Journal of Translational Medicine, 2019
Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute ...
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler   +21 more
doaj   +1 more source

Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk, Tina Okdahl, Marietta Kokla, Tommi Suvitaival, Gurjeet Kaur, Ismo M. Mattila, Simon M. Kienle, Christian Buhl, Knud Yderstræde, Troels S. Jensen, Peter Rossing, Flemming Pociot, Birgitte Brock, Cristina Legido‐Quigley, Páll Karlsson, Christian S. Hansen, Christina Brock, Joachim Størling, Karolina Sulek   +18 more
wiley   +1 more source

Enzymatic synthesis of Lysophosphatidylcholines

, 2017
Les lysophosphatidylcholines (LPCs), molécules amphiphiles, peuvent jouer le rôle d'un vecteur pour des acides gras d'intérêt. Ces molécules peuvent être synthétisées par voie enzymatique. Ce travail a pour objectif de synthétiser des LPCs contenants des
Mnasri, Taha
core