Results 71 to 80 of about 7,630 (250)

Langmuir monolayer characteristics of erucylphosphocholine : a novel anti-tumor drug [PDF]

, 2012
Erucylphosphocholine, an alkylphosphocholine anticancer drug, was employed for Langmuir monolayer characterization and liquid crystalline studies.
Dynarowicz-Łątka, Patrycja, Marzec, Monika, Wnętrzak, Anita, Łątka, Kazimierz   +3 more
core   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance [PDF]

, 2017
Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging ...
Daenen, Laura G.M., Hansen, Steffen V.F., Hirasawa, Akira, Houthuijzen, Julia M., Hudson, Brian D., Ishihara, Kenji, Jaarsveld, Marijn T.M., McLean, Chelsea M., Milligan, Graeme, Oosterom, Ilse, Peeper, Daniel S., Roodhart, Jeanine M.L., Sadatmand, Sahar Jafari, Ulven, Trond, van de Lest, Chris H.A., Voest, Emile E.   +15 more
core   +12 more sources

Chemical mechanism of lysophosphatidylcholine: lysophosphatidylcholine acyltransferase from rabbit lung. pH-dependence of kinetic parameters [PDF]

Biochemical Journal, 1990
Lysophosphatidylcholine: lysophosphatidylcholine acyltransferase is an enzyme that catalyses two reactions: hydrolysis of lysophosphatidylcholine and transacylation between two molecules of lysophosphatidylcholine to give disaturated phosphatidylcholine.
J, Pérez-Gil, J, Martín, C, Acebal, R, Arche   +3 more
openaire   +2 more sources

Accumulation of alkyl-lysophosphatidylcholines in Niemann-Pick disease type C1

Journal of Lipid Research
Lysosomal function is impaired in Niemann-Pick disease type C1 (NPC1), a rare and inherited neurodegenerative disorder, resulting in late endosomal/lysosomal accumulation of unesterified cholesterol.
Sonali Mishra, Pamela Kell, David Scherrer, Dennis J. Dietzen, Charles H. Vite, Elizabeth Berry-Kravis, Cristin Davidson, Stephanie M. Cologna, Forbes D. Porter, Daniel S. Ory, Xuntian Jiang   +10 more
doaj   +1 more source

Investigation of metabolites for estimating blood deposition time [PDF]

, 2017
This study was supported by a UK Biotechnology and Biological Sciences Research Council (BBSRC) Grant (BB/I019405/1) to DJS, grant 727.011.001 from the Netherlands Organization for Scientific Research (NWO) Forensic Science Program to MK and by Erasmus ...
Ackermann, Katrin, Ang, Joo Ern, Davies, Sarah K., Hoveijn, Igor, Hut, Roelof A., Kayser, Manfred, Lech, Karolina, Liu, Fan, Middleton, Benita, Raynaud, Florence J., Revell, Victoria L., Skene, Debra J.   +11 more
core   +7 more sources

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Lysophosphatidylcholine inhibits membrane‐associated SNARE complex disassembly [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractIn cells, N‐ethylmaleimide‐sensitive factor (NSF) attachment protein receptors called SNAREs are involved in membrane fusion. In neurons, for example, target membrane proteins SNAP‐25 and syntaxin called t‐SNAREs present at the pre‐synaptic membrane, and a synaptic vesicle‐associated membrane protein (VAMP) or v‐SNARE, is part of the conserved ...
Shin, Leah, Wang, Sunxi, Lee, Jin-Sook, Flack, Amanda, Mao, Guangzhao, Jena, Bhanu P   +5 more
openaire   +2 more sources

Association between the third trimester maternal serum metabolome and child growth and development through the first year of life

Scientific Reports
Evidence suggests that maternal metabolome may be associated with child health outcomes. We analyzed the association between the maternal metabolome between 28–35 gestational weeks and child growth and development during the first year.
Samary da Silva Rosa Freire, Marina Padilha, Ana Lorena Lima Ferreira, Raquel Machado Schincaglia, Amanda Caroline Cunha Figueiredo, Nathalia Cristina Freitas-Costa, Xiaofei Yin, Lorraine Brennan, Gilberto Kac   +8 more
doaj   +1 more source

Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro

Cell Reports, 2022
Summary: Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection
Joann Diray-Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, Matthew A. Pettengill, Mark Liu, Simon D. van Haren, Scott D. McCulloch, Greg Michelloti, Olubukola Idoko, Tobias R. Kollmann, Beate Kampmann, Hanno Steen, Al Ozonoff, Jessica Lasky-Su, Christine S. Benn, Ofer Levy   +17 more
doaj   +1 more source