Results 81 to 90 of about 6,447 (173)

Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Use of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 1 diabetes (T1D) is limited by increased risk of ketoacidosis. We aimed to determine metabolic pathways affected by SGLT2i treatment in adults with T1D during ketosis induced by insulin withdrawal.
Rosa Yang, Kevin Cho, Max C. Petersen, Kai E. Jones, Gary J. Patti, Janet B. McGill, Samantha A. DiGruccio   +6 more
wiley   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

Immunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan, David E. Phelan, Xiaofei Yin, Lorraine Brennan, Martina Wallace, Eoin P. Cummins   +5 more
wiley   +1 more source

Multiplex FAD2/FATB Editing Generates Ultra‐High‐Oleic, Low‐Saturate Soybean With Increased Seed Fatty Acid Content

Plant Biotechnology Journal, EarlyView.
ABSTRACT Oleic acid (18:1), saturated fatty acid (SFA), and polyunsaturated fatty acid (PUFA) levels are important traits for storage stability and edibility. In this study, we aimed to develop high‐oleic soybean (Glycine max) by simultaneously targeting fatty acid desaturase 2 (FAD2) and fatty acyl‐ACP thioesterase B (FATB) gene families using CRISPR ...
Won Nyeong Kim, Yu‐Ri Choi, Hye Jeong Kim, Young‐Soo Chung, Hyun Uk Kim   +4 more
wiley   +1 more source

Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients

Arthritis Research & Therapy, 2019
Background Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogeneity of the disease, and need for ...
Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman, Johanne Martel-Pelletier   +5 more
doaj   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Investigating plasma lipid profiles in association with Parkinson’s disease risk

npj Parkinson's Disease
Parkinson’s Disease (PD) is associated with lipid metabolic disturbances, but the specific roles of lipids in its pathogenesis are unclear. This Mendelian Randomization (MR) study utilized GWAS data and IVW methods to investigate plasma lipids and PD ...
Houwen Zhang, Fangzheng Cao, Jialin Yu, Yu Liang, You Wu   +4 more
doaj   +1 more source

Artificial reproduction of sturgeon: The correlation between the lipid composition of caviar and it fish breeding quality [PDF]

BIO Web of Conferences
In our research we study of the correlation between the biochemical composition of unfertilized sturgeon caviar and the results of its incubation. We studies besters (bester is a hybrid of beluga and sterlet) and stellate sturgeon caviar.
Vassel Sergei, Vassel Natalia
doaj   +1 more source

Metabolic pattern across energy imbalance: An exploratory metabolomics study of female body weight extremes including anorexia nervosa and athletes

Experimental Physiology, EarlyView.
Abstract In anorexia nervosa (AN), prolonged metabolic adaptation to severe energy deficiency can impair treatment efficacy. Similarly, low energy availability poses a recognized risk to athletes, potentially compromising health and performance. This cross‐sectional study aimed to characterize the plasma metabolic pattern of females with varying ...
Sonja Lackner, Olli Kärkkäinen, Sabrina Mörkl, Wolfram Müller, Alfred Fürhapter‐Rieger, Kati Hanhineva, Sandra Johanna Holasek   +6 more
wiley   +1 more source

Lysophosphatidylcholines Enriched with cis and trans Palmitoleic Acid Regulate Insulin Secretion via GPR119 Receptor

Among lipids, lysophosphatidylcholines (LPCs) with various fatty acyl chains have been identified as potential agonists of G protein-coupled receptors (GPCRs). Recently, targeting GPCRs has been switched to diabetes and obesity.
Marcin Szustak (17763806), Sylwester Czaplicki (17763818), Arkadiusz Chworos (2196373), Erfan Tabandeh (17763821), Iwona Konopka (17763824), Eliza Korkus (17763809), Anna Gliszczyńska (17763827), Grzegorz Dąbrowski (17763815), Edyta Gendaszewska-Darmach (4518808), Gabriela Maciejewska (4389295), Maria Koziołkiewicz (2183312), Rafal Madaj (17763812)   +11 more
core   +1 more source

Associations of plasma HDL subclasses with incident dementia risk in older adults

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Plasma high‐density lipoprotein (HDL) varies in size. We examined the associations between HDL subclasses and their lipid composition and incident dementia risk in older adults. METHODS We included 23,790 United Kingdom (UK) Biobank (UKB) and 147 Atherosclerosis Risk in Communities (ARIC) older adults free of dementia at baseline.
Binchong An, Suad Ali, Karen Smith, Samantha Roemhild, Lindsey Neumann, Dwight R. Stoll, Ling Li, Pamela L Lutsey, Michelle M Mielke, Fang Yu, Ron C Hoogeveen, Lin Zhang, Alvaro Alonso, Danni Li   +13 more
wiley   +1 more source