Results 61 to 70 of about 6,447 (173)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines

, 1995
This paper concerns the mechanistic elucidation of a certain class of absorption enhancers within the group of phospholipids, lysophosphatidylcholines. The studies were performed in Caco-2 monolayers.
Helle Brøndsted, Lars Hovgaard, Nielsen, Hanne Mørck, Hovgaard, Lars, Hanne Mørck Nielsen, Brøndsted, Helle   +5 more
core   +1 more source

Heatmap with euclidean distance and ward clustering of mean serum metabolites determined by DI-MS in overweight cats (n = 14) receiving control (no additional choline supplementation, 1.2 x NRC RA, 77 mg/kg BW0.67), choline at 2 x NRC RA (126 mg/kg BW0.67), 4 x NRC RA (252 mg/kg BW0.67), 6 x NRC RA (378 mg/kg BW0.67), and 8 x NRC RA (504 mg/kg BW0.67), in a 5 x 5 Latin square design for 3-week periods, with a significant effect of choline dose (P < 0.05).

, 2023
Metabolites are separated into a) biogenic amines, amino acids, amino acid derivatives, ammonium compounds, organic sugars and acids; b) acylcarnitines; c) phosphatidylcholines, lysophosphatidylcholines, sphingomyelins and hydroxysphingomyelins.
Gordon Kirby (10076857), Anna K. Shoveller (6208457), Marica Bakovic (722729), Adronie Verbrugghe (3485333), Alexandra Rankovic (12256596), Hannah Godfrey (12256593), Caitlin E. Grant (12256599)   +6 more
core   +1 more source

Accumulation of alkyl-lysophosphatidylcholines in Niemann-Pick disease type C1

Journal of Lipid Research
Lysosomal function is impaired in Niemann-Pick disease type C1 (NPC1), a rare and inherited neurodegenerative disorder, resulting in late endosomal/lysosomal accumulation of unesterified cholesterol.
Sonali Mishra, Pamela Kell, David Scherrer, Dennis J. Dietzen, Charles H. Vite, Elizabeth Berry-Kravis, Cristin Davidson, Stephanie M. Cologna, Forbes D. Porter, Daniel S. Ory, Xuntian Jiang   +10 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Lysophosphatidylcholines activate PPAR delta and protect human skeletal muscle cells from lipotoxicity

, 2016
Metabolomics studies of human plasma demonstrate a correlation of lower plasma lysophosphatidylcholines (LPC) concentrations with insulin resistance, obesity, and inflammation. This relationship is not unraveled on a molecular level. Here we investigated
Weigert, Cora, Zhao, Xinjie, Adhikary, Till, Lehmann, Rainer, Schleicher, Erwin, Klingler, C., Weigert, C., Haring, Hans-Ulrich, Zhao, X., Schleicher, E., Li, Jia, Lehmann, R., Adhikary, T., Xu, G., Häring, H.U., Li, J., Klingler, Christian, Xu, Guowang   +17 more
core   +1 more source

Targeted Lipid Analysis of Haemolytic Mycelial Extracts of Aspergillus niger

Molecules, 2014
Ethanolic extracts of mycelia from Aspergillus niger (strain N402) grown in liquid media were observed to have haemolytic activity on bovine erythrocytes. This haemolytic activity decreased significantly during the time of growth (1–3 days).
Maruša Novak, Kristina Sepčić, Nada Kraševec, Igor Križaj, Peter Maček, Gregor Anderluh, Graziano Guella, Ines Mancini   +7 more
doaj   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

Co-Transplantation of Human Neurotrophic Factor Secreting Cells and Adipose-Derived Stem Cells in Rat Model of Multiple Sclerosis

Cell Journal, 2018
Objective The presence of neurotrophic factors is critical for regeneration of neural lesions. Here, we transplanted combination of neurotrophic factor secreting cells (NTF-SCs) and human adipose derived stem cells (hADSCs) into a lysolecithin model of ...
Shahnaz Razavi, Nazem Ghasemi, Mohammad Mardani, Hossein Salehi   +3 more
doaj   +1 more source