Results 91 to 100 of about 6,447 (173)

Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children

, 2021
Background: The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes.
Francisco Madrid-Gambin (3839722), Aoife O'Gorman (10260984), Mary Cannon (7895894), Melanie Focking (7895924), Sean Madden (10260987), Caitriona Scaife (156268), Matej Orešič (43155), David Cotter (7895345), Jane A English (10260981), Stanley Zammit (149484), Linda Ahonen (8980607), Tuulia Hyötyläinen (139327), Meike Heurich (10260766), Tommi Suvitaival (6505544), Ismo Mattila (198926), Glyn Lewis (49550), Gerard Cagney (177566), Sophie Sabherwal (3343517), Lorraine Brennan (449247)   +18 more
core   +2 more sources

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit, Kornkamon Lertsuwan, Natnicha Tannop, Ploypapus Lapatkeattisukul, Thanayuth Jenpichitkulchai, Nittiyaporn Sotapong, Jarinthorn Teerapornpuntakit, Tueanjai Khunluck, Siriwan Punvilai, Narattaphol Charoenphandhu   +9 more
wiley   +1 more source

Tai Chi Improves Brain Functional Connectivity and Plasma Lysophosphatidylcholines in Postmenopausal Women With Knee Osteoarthritis: An Exploratory Pilot Study

, 2022
Copyright © 2022 Shen, Watkins, Kahathuduwa, Chyu, Zabet-Moghaddam, Elmassry, Luk, Brismée, Knox, Lee, Zumwalt, Wang, Wager and Neugebauer. cc-byObjective: A pre/post pilot study was designed to investigate neurobiological mechanisms and plasma ...
Luk, Hui Ying, Wager, Tor D., Zabet-Moghaddam, Masoud, Kahathuduwa, Chanaka, Neugebauer, Volker, Shen, Chwan Li, Wang, Rui, Watkins, Bruce A., Elmassry, Moamen M., Zumwalt, Mimi, Brismée, Jean Michel, Lee, Jaehoon, Chyu, Ming Chien, Knox, Ami   +13 more
core   +1 more source

In situ, Reversible Gating of a Mechanosensitive Ion Channel through Protein-Lipid Interactions

Frontiers in Physiology, 2016
Understanding the functioning of ion channels, as well as utilizing their properties for biochemical applications requires control over channel activity.
Anna Dimitrova, Anna Dimitrova, Martin Walko, Martin Walko, Maryam Hashemi Shabestari, Pravin Kumar, Martina Huber, Armagan Kocer   +7 more
doaj   +1 more source

Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2‐Dependent Downregulation of Endothelial MFSD2A

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Hyperglycemia induces retinal microglial activation and CTSS upregulation, disrupting microglia‐endothelial crosstalk via PAR2‐dependent MFSD2A suppression. Abnormal activation of microglia amplifies retinal inflammatory cascade, enhances transcytosis, compromises BRB integrity, and accelerates DR progression.
Chengye Xu, Hongxue Li, Qian Xu, Kangqi Zhao, Yangwen Chen, Yan Wang, Wei Zou, Binglin Kuang, Hongyu Kuang   +8 more
wiley   +1 more source

Dystonic opisthotonus: A rare phenotype of adrenoleukodystrophy

Annals of Movement Disorders, 2019
X-linked adrenoleukodystrophy (X-ALD) is a pan-ethnic disorder and affects approximately 1:20,000 males (Moser HW, Mahmood A, Raymond GV. X-linked adrenoleukodystrophy.
Sindhu D Mallikarjuna, Sadanandavalli R Chandra, Hansashree Padmanabha, Rita Christopher   +3 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Obesity-Related Metabolomic Profiles and Discrimination of Metabolically Unhealthy Obesity

, 2018
A particular subgroup of obese adults, considered as metabolically healthy obese (MHO), has a reduced risk of metabolic complications. However, the molecular basis contributing to this healthy phenotype remains unclear.
Abolghasem Djazayery (4994681), Olaf Uhl (745421), Berthold Koletzko (144194), Mir Saeed Yekaninejad (693368), Ali Sheidaie (4994690), Maryam Chamari (4994684), Zahra Kalantar (4994687), Farshad Farzadfar (439490), Lu Qi (160573), Oana A. Zeleznik (4994678), Zarin Ebrahimi (4994675), Minoo Bagheri (1468900)   +11 more
core   +2 more sources

Mutual antagonism between auxin and diacylglycerol acyltransferase 2 regulates high‐temperature‐induced hypocotyl elongation

New Phytologist, Volume 252, Issue 1, Page 222-240, October 2026.
Proposed model for auxin–DGAT2 crosstalk regulating high‐temperature‐induced hypocotyl elongation. Summary Cell elongation is a fundamental process in plant growth and development, and it is significantly affected by temperature changes. While the signaling mechanisms driving high‐temperature‐induced cell elongation have been extensively studied, the ...
Mohinur Khamzaaliyeva, Punita Lalchand, Didier‐Deschamps Ashley, Xue Pan   +3 more
wiley   +1 more source

Concentrations of LPCs and LPEs in liver tissues of chow diet and HFD fed rats at 24 weeks.

, 2014
Concentrations of lysophosphatidylcholines (LPC) and lysophosphatidylethanolamines (LPE) were significantly higher in liver tissues of HFD fed rats.
Markus R. Wenk (136744), Christiani Jeyakumar Henry (538175), Guanghou Shui (136742), Jadegoud Yaligar (538172), E. Shyong Tai (103763), Ong Wee Kiat (538174), Buu Duyen Lam (222171), Shigeki Sugii (387157), S. Sendhil Velan (538176), Venkatesh Gopalan (538173)   +9 more
core   +1 more source