Results 221 to 230 of about 633,779 (297)

EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis. [PDF]

Gut Microbes
Orsini Delgado ML, Baudesson de Chanville C, Pfister H, Bardouillet L, Farin W, Rinaudo P, Quessel J, Strozzi F, Pereira H, Maresca M, Nicoletti C, Di Pasquale E, Mailhac C, Thomas V, Blum S, Chevalier G, Toussaint H, Luangsay S, Bonny C, Chene L, Cultrone A.   +20 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Turning off inflammation naturally via dual antioxidant and anti-inflammatory actions of chestnut wood extract through PPARγ and NF-κB pathways. [PDF]

PLoS One
Lambert D, Buisine M, Billamboz M, Jawhara S.   +3 more
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

HIV transgenic mouse monocytes display increased <i>in vivo</i> migration across the blood-brain barrier associated with increased expression of genes associated with mononuclear leukocyte movement. [PDF]

J Virol
Sydenstricker A, Lee D, Voss A, Zheng JH, Hur H, Kandpal M, Goldstein H.   +6 more
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury. [PDF]

Redox Rep
Lin W, Dong C, Jiang Q, Lou Y, Wang L, He Z.   +5 more
europepmc   +1 more source

Extreme Polaritonic Interactions in a Room‐Temperature Designable Sub‐Nanocavity Quantum Electrodynamic Platform

Advanced Science, EarlyView.
 A nanoparticle‐cluster‐on‐mirror (NPcoM) serves as a functionally deterministic sub‐nanocavity that emulates picocavities, enabling extreme light–matter interactions and polaritonic phenomena. ABSTRACT Pushing nanoscale optical confinement to its ultimate limits defines the regime of nano‐cavity quantum electrodynamics (nano‐cQED), where light‐matter ...
Huatian Hu, Xin Shu, Zhiwei Hu, Di Zheng, Ruiqian Zhang, Ximin Cui, Wei Dai, Xiang Lan, Xiaobo Han, Wen Chen, Hongxing Xu   +10 more
wiley   +1 more source

Conservation of Bacterial Lipopolysaccharide Binding by SARS-CoV-2 Spike across Major Viral Variants. [PDF]

Comput Struct Biotechnol J
Samsudin F, Petruk G, Rui L, Schmidtchen A, Bond PJ.   +4 more
europepmc   +1 more source