Results 241 to 250 of about 450,617 (310)

Pharmacological activation of SIRT1 alleviates sepsis-associated acute kidney injury by improving renal mitochondrial energy metabolism. [PDF]

Ren Fail
Zhu R, Yang H, Liu L, Gao Y, Gao X.
europepmc   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Interleukin-1 mediates innate immune signaling and antiviral defense in islets. [PDF]

Life Sci Alliance
Bartosiak JT, Hansen PA, Kasomva K, Rao S, Corbett JA.   +4 more
europepmc   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Remimazolam Attenuates Neurological Injury After TBI: A Potential Role of α7nAChR-Associated Mitophagy Enhancement and Pyroptosis Suppression in BV2 Cells. [PDF]

Drug Des Devel Ther
Li L, Bao R, Meng Y, Li X, Li H, Duan P, Bi Y, Chen J, Xing Y, Luo L, Yu Y, Yu M, Cui M, Zhang B.   +13 more
europepmc   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Eleutheroside B alleviates LPS-induced lung injury in chicks by regulating autophagy via the AMPK/mTOR signaling pathway. [PDF]

Poult Sci
Zhang B, Li F, Liu C, Li X, Zhang L, Yan H, Zhao R, Yuan Z, Li K, Xin A.   +9 more
europepmc   +1 more source

Effect of longevity genotype on acute phase response to a lipopolysaccharide challenge in dairy goats. [PDF]

PLoS One
Ithurbide M, Rupp R, Fassier T, Friggens NC, Foucras G.   +4 more
europepmc   +1 more source

Goreisan-mediated suppression of chemokine and cytokine production in astrocytes under AQP4-expressing conditions. [PDF]

Front Neurosci
Murakami K, Shimizu T, Kido T, Isohama Y.   +3 more
europepmc   +1 more source

Association of CD16^hiCD62L^lo Neutrophils with Disease Severity and Impact of SYK Inhibition in Sepsis. [PDF]

J Inflamm Res
Yao X, Teague HL, Knabe LE, Santana da Cruz R, Williams T, Lemma Woldehanna M, Evans E, Hobson A, Wilkinson JD, Demirkale CY, Nathan SD, King C, Strich JR.   +12 more
europepmc   +1 more source