Results 241 to 250 of about 633,779 (297)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon   +21 more
wiley   +1 more source

Anion-sublattice engineering of Li<sub>3</sub>PS<sub>4</sub>:Br and I incorporation enhances ionic conductivity and Li-metal compatibility. [PDF]

open access: yesChem Sci
Poudel TP   +10 more
europepmc   +1 more source

Colchicine has Dose-Dependent Therapeutic Effects in a LPS-Induced Experimental Endotoxemia Model. [PDF]

open access: yesPharmacol Res Perspect
Demir M   +5 more
europepmc   +1 more source

Igalan attenuates sepsis-induced inflammation through covalent targeting of the NLRP3 inflammasome pathway. [PDF]

open access: yesRSC Chem Biol
Hou C   +15 more
europepmc   +1 more source

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