Results 171 to 180 of about 53,833 (282)

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Auxin biosynthetic key gene <i>CpYUC10B</i> in embryo involved in large-fruited Chinese cherry massive abscission during the pit hardening process. [PDF]

Front Plant Sci
Wang H, Liu X, Su Q, Yang Y, Wu X, Zhang J, Wang Y, He W, Wu Z, Li M, Chen Q, Luo Y, Zhang Y, Tang H, Wang X.   +14 more
europepmc   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

LQ Control without Riccati Equations: Stochastic Systems

We study stochastic linear--quadratic (LQ) optimal control problems over an infinite horizon, allowing the cost matrices to be indefinite. We develop a systematic approach based on semidefinite programming (SDP).
Zhang, S., Yao, D.D., Zhou, X.Y.
core   +1 more source

Microdosimetric characterization of proton relative biological effectiveness in pancreatic ductal adenocarcinoma cell lines. [PDF]

Front Oncol
Wang T, Li Y, Campelo SN, Bronk L, Taylor PA, Fujimoto TN, Jiang D, Koong AC, Guan F.   +8 more
europepmc   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Minimising mutation load as a mechanism for low-dose hyper-radiosensitivity and induced radioresistance. [PDF]

Sci Rep
Polgár S, Madas BG.
europepmc   +1 more source

Trap‐Programmable Ruddlesden–Popper Perovskite Nanocrystals for Persistent Optoelectronic Memory and Photonic Synapses

Advanced Science, EarlyView.
This work presents trap‐programmable Ruddlesden–Popper perovskite nanocrystals for ultralong‐lived optical memory and photonic synapses. Layer‐controlled octahedral distortion modulates trap depth and carrier‐storage kinetics, enabling persistent luminescence beyond 5000 s at room temperature.
Xuanyu Zhu, Qi Liu, Qi Wei, Hui Ren, Luwei Zhou, Jiangbo Peng, Yuxuan Chen, Jiatong Wang, Leyi Zhao, Pengzhi Wang, Xue Hao, Ting Wang, Mingjie Li   +12 more
wiley   +1 more source

Linguistic q-rung orthopair fuzzy group decision-making approach based on new bidirectional projection and generalized knowledge measure. [PDF]

Sci Rep
Qin Y, Liu Y, Rong Y.
europepmc   +1 more source

Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links

Advanced Science, EarlyView.
An analytical framework reveals how global coupling, second‐harmonic strength, noise, and network structure govern oscillator‐based Ising dynamics. Spectral reduction predicts stability boundaries, while Fokker–Planck analysis captures one‐ to two‐cluster transitions and identifies conditions favoring low‐energy configurations.
Qiang Li, Chumin Sun, David Waxman, Renaud Lambiotte, Jie Sun, Peng Ji   +5 more
wiley   +1 more source