Protection against myocardial ischemia reperfusion injury by liquiritin: involvement of autophagy restoration targeting PIK3CA [PDF]
Brazilian Journal of Medical and Biological ResearchThe current therapy for myocardial infarction focuses on reestablishing blood flow in the coronary arteries to reduce the ischemic area, but the subsequent damage caused by reperfusion cannot be ignored.
Huizi Mao, Zhuqing Li, Chengzhi Lu
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Liquiritin restores metabolic homeostasis in NAFLD by modulating AKT1/FOXO1 signaling [PDF]
Frontiers in PharmacologyBackgroundNon-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition with a complex and multifactorial pathogenesis.PurposeThis study aimed to investigate the mecha-nism of liquiritin (LQ) in NAFLD for its treatment.MethodsThis ...
Zhirun Zhang +8 more
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Antidepressant effect of licorice total flavonoids and liquiritin: A review
Heliyon, 2023 With the development of society and changes in lifestyle, major depressive disorder (MDD) has become a significant disease that plagues many people. Licorice, an excellent natural medicine with a long history of cultivation and application, is found in ...
Meina Yang, Ruyu Wang, Jinxin Du
exaly +3 more sources
Complete genome sequencing of Lactobacillus pentosus HP-B1718 and identification of the key enzyme for liquiritin biotransformation [PDF]
Frontiers in MicrobiologyIntroductionAs a free aglycone with higher bioavailability and pharmacological activity, liquiritigenin can be obtained from liquiritin (liquiritigenin-4’-O-β-D-glucoside) catalyzed by Aryl-phospho-beta-D-glucosidase (designated as ApgA).
Zhi-Wen Tan +8 more
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Discovery of natural scaffolds as HER2 inhibitors for breast cancer: virtual screening, molecular dynamics, and biological characterization with selectivity profiling [PDF]
Scientific ReportsNature offers potential therapeutic candidates for breast cancer (BC), and targeting HER2 signaling presents a promising approach, leveraging the successful history of anticancer drug discovery.
Asmaa Hossam +4 more
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Physiological mechanisms of Piriformospora indica- Glycyrrhiza Uralensis Fisch symbiosis in regulating growth and medicinal compound biosynthesis under salt stress [PDF]
Frontiers in Plant ScienceIntroductionGlycyrrhiza uralensis Fisch. is a medicinal plant commonly cultivated in salinized soils, where environmental stress suppresses the accumulation of pharmaceutically active components.
Su-yang Tang +5 more
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Ameliorative Effects of Liquiritin Carbomer Gel on Dinitrofluorobenzene-Induced Atopic Dermatitis in Mice [PDF]
GelsAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dryness and itching. Steroids are the most common therapeutic agents, may induce skin atrophy, and damage the skin barrier.
Yun Zhang +5 more
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Lanthanum enhances biomass and bioactive metabolite production in Glycyrrhiza uralensis via coordinated gene regulation [PDF]
Frontiers in Plant ScienceIntroductionGlycyrrhizic acid, liquiritin, and liquiritigenin are key secondary metabolites in Glycyrrhiza uralensis Fisch. with significant pharmacological value.
Yuanyang Shao +9 more
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Effect of liquiritin on the expression of BDNF, Bax, and Bcl-2 in the hippocampus of post-stroke depression rats [PDF]
Cerebral Circulation - Cognition and BehaviorAims: The study intended to explore the therapeutic effect of liquiritin on PSD rats and its role in the pathogenesis of PSD. Methods: The stroke model was established via middle cerebral artery occlusion, and the PSD model was created using chronic ...
Gui-Liu Yan +4 more
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Synergistic Effects of Rhizophagus irregularis and Trichoderma harzianum Co-Inoculation on Enhancing Drought Tolerance and Secondary Metabolite Production in Licorice (Glycyrrhiza uralensis) [PDF]
Journal of FungiDrought stress significantly hinders the cultivation of medicinal plants such as licorice (Glycyrrhiza uralensis), valued for its bioactive compounds, glycyrrhizin, and liquiritin.
Kangxu Zhang +9 more
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