Results 1 to 10 of about 2,651 (189)

Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways [PDF]

Medicines (Basel, Switzerland), 2019
Background: Liquiritin (LQ) and its aglycone, liquiritigenin (LQG), are major flavonoids in licorice root (Glycyrrhiza spp.). Our preliminary screening identified LQ and LQG, which promote melanin synthesis in the melanoma cells.
Yukihiro Shoyama, Tomoe Ohta, Shunsuke Fujii   +2 more
exaly   +7 more sources

Antidepressant effect of licorice total flavonoids and liquiritin: A review

Heliyon, 2023
With the development of society and changes in lifestyle, major depressive disorder (MDD) has become a significant disease that plagues many people. Licorice, an excellent natural medicine with a long history of cultivation and application, is found in ...
Meina Yang, Ruyu Wang, Jinxiang Han
exaly   +5 more sources

Protection against myocardial ischemia reperfusion injury by liquiritin: involvement of autophagy restoration targeting PIK3CA [PDF]

Brazilian Journal of Medical and Biological Research
The current therapy for myocardial infarction focuses on reestablishing blood flow in the coronary arteries to reduce the ischemic area, but the subsequent damage caused by reperfusion cannot be ignored.
Huizi Mao, Zhuqing Li, Chengzhi Lu
doaj   +2 more sources

Liquiritin restores metabolic homeostasis in NAFLD by modulating AKT1/FOXO1 signaling [PDF]

Frontiers in Pharmacology
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition with a complex and multifactorial pathogenesis.PurposeThis study aimed to investigate the mecha-nism of liquiritin (LQ) in NAFLD for its treatment.MethodsThis ...
Zhirun Zhang, Sue Jiao, Tao Jiang, Ru Zhang, Zhuangzhuang Sun, Zhaopeng Zhang, Yanfang Pan, Junpeng Guo, Junpeng Guo   +8 more
doaj   +2 more sources

Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism [PDF]

Frontiers in Physiology, 2019
Low progesterone level is always linked with pre-term birth. Therefore, maintaining of progesterone level is vital during pregnancy. Aldo-keto reductase family one member C1 (AKR1C1) catalyzes the reduction of progesterone to its inactive form of 20 ...
Chenming Zeng, Difeng Zhu, Jun You, Xiaowu Dong, Bo Yang, Hong Zhu, Qiaojun He   +6 more
doaj   +3 more sources

A comprehensive review on the pharmacological effects of Liquiritin

Journal of Functional Foods
Glycyrrhiza is a significant resource in both traditional Chinese medicine (TCM) and functional foods. Liquiritin, a flavonoid glycoside derived from the roots of Glycyrrhiza species, exhibits a broad spectrum of pharmacological activities.
Jie Gao, Yi Shi, Mei Luo, Haojie Zheng
doaj   +2 more sources

Discovery of natural scaffolds as HER2 inhibitors for breast cancer: virtual screening, molecular dynamics, and biological characterization with selectivity profiling [PDF]

Scientific Reports
Nature offers potential therapeutic candidates for breast cancer (BC), and targeting HER2 signaling presents a promising approach, leveraging the successful history of anticancer drug discovery.
Asmaa Hossam, Ingy I. Abdallah, Nadia A. El-Sebakhy, Radwan Alnajjar, Mohamed M. Mohyeldin   +4 more
doaj   +2 more sources

Physiological mechanisms of Piriformospora indica- Glycyrrhiza Uralensis Fisch symbiosis in regulating growth and medicinal compound biosynthesis under salt stress [PDF]

Frontiers in Plant Science
IntroductionGlycyrrhiza uralensis Fisch. is a medicinal plant commonly cultivated in salinized soils, where environmental stress suppresses the accumulation of pharmaceutically active components.
Su-yang Tang, Peng-fei Liu, Chen Fu, Si-ying Tang, Xian-fu Zhou, Bing-gan Lou   +5 more
doaj   +2 more sources

Complete genome sequencing of Lactobacillus pentosus HP-B1718 and identification of the key enzyme for liquiritin biotransformation [PDF]

Frontiers in Microbiology
IntroductionAs a free aglycone with higher bioavailability and pharmacological activity, liquiritigenin can be obtained from liquiritin (liquiritigenin-4’-O-β-D-glucoside) catalyzed by Aryl-phospho-beta-D-glucosidase (designated as ApgA).
Zhi-Wen Tan, Xiang-Rui Mao, Qian-Meng Qi, Xiao-Han Wang, Meng-Jie Liu, Hang Wu, Lan-Fang Li, Zhao-Sen Fan, Shao-Yang Hou   +8 more
doaj   +2 more sources

Electrochemical Detection of Liquiritin in Liquorice Based on Carbon Materials

International Journal of Electrochemical Science, 2016
To quantify liquiritin, an electrochemical sensor was synthesized with a glassy carbon electrode (GCE), which was modified by the carboxylic acid-based graphene (C-GO) and acidified MWCNT.
Mei Wang, Yingjuan Qu, Jing Sun, Jinglin Li, Suiling Zhang, Yajun Shi   +5 more
doaj   +2 more sources