Results 41 to 50 of about 2,750 (162)

Comparison of efficacy of topical 2% liquiritin, topical 4% liquiritin and topical 4% hydroquinone in the management of melasma

, 2016
Background Melasma is an acquired irregular brownish hyperpigmentation of face and occasionally neck with a poorly understood etiology. Hydroquinone-based formulations remain the mainstay of treatment.
Shazia Zubair, Ghulam Mujtaba
core   +1 more source

Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination

Frontiers in Pharmacology, 2022
Neuropathic pain (NP) affects 7%–10% of the general population and is still hard to cure. Here, we validated the therapeutic effect and demonstrated the mechanism of paeoniflorin and liquiritin combination (PL) on NP from the perspective of integrated ...
Yan-Yan Chen, Li-Mei Feng, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Mei-Mei Zhang, Yu-Ping Tang   +6 more
doaj   +1 more source

Efficacy of topical 4% liquiritin compared with topical 4% liquiritin mixed in 5% ascorbic acid in the treatment of melasma

, 2016
Objective To compare the efficacy of topical 4% liquiritin alone with combination of topical 4% liquiritin and topical 5% ascorbic acid for the treatment of melasma.
Raheel Tahir, Ghulam Mujtaba, Shamshad Akram, Farah Sattar   +3 more
core   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Arbuscular mycorrhiza facilitates the accumulation of glycyrrhizin and liquiritin in Glycyrrhiza uralensis under drought stress

, 2018
Liquorice (Glycyrrhiza uralensis) is an important medicinal plant for which there is a huge market demand. It has been reported that arbuscular mycorrhizal (AM) symbiosis and drought stress can stimulate the accumulation of the active ingredients ...
Zhou, Xiaofu, Zhang, Xin, Xu, Lijiao, Jiang, Xuelian, Zhao, Aihua, Wu, Songlin, Chen, Baodong, Xie, Wei, Hao, Zhipeng   +8 more
core   +1 more source

Simultaneous determination of five index components in Astragalus granule by HPLC assay

Siliao yanjiu, 2022
The study aimed to develop an HPLC method for the simultaneous determination of calycosin 7-O-glucoside, liquiritin, calycosin, ononin and glycyrrhizic acid in Astragalus granule.
Xiang-peng KONG, Hai-qin REN, Jia-min WANG, Zi-jing JIA, Xiao-ying LIU, Ying-li WANG   +5 more
doaj  

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

Phytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen, Xin Dong, Haowen Zhuang, Yusheng Huang, Mengyuan Wang, Zhongzheng Zhang, Jinhong Chen, Wei Wang, Chun Li, Junyan Wang   +9 more
wiley   +1 more source

AI‐enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug‐induced liver injury

Smart Molecules, EarlyView.
An AI‐driven framework integrating disease‐network analysis, direction‐aware molecular screening, and carrier‐free co‐assembly engineering enables nanomedicine design. The dual‐constraint deep learning model predicts API–target affinity and regulatory direction to prioritize complementary APIs.
Kai Xiao, Meng Fan, Haoyu Zheng, Boyuan Gu, Shaowen Wang, Ziping Wu, Shiming Zhang, Xin Zhao, Wensheng Zhang, Quanxin Ning, Sigen A, Chao Yang, Huayi Sun, Ren Mo, Dan Shao   +14 more
wiley   +1 more source

Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This study evaluates Xiaoyaosan (XYS) for bipolar disorder (BD) using network pharmacology and experimental validation. Molecular docking reveals interactions between active XYS compounds and potential core targets. Animal experiments confirm XYS alleviates BD‐like behaviors in mice by suppressing core targets, elucidating its multi‐target mechanism ...
Man Chen, Nana Ding, Xingmin Qiu, Lan Li, Yali Guo, Rongyanqi Wang, Xiaowei Mo, Tan Zou, Shangzhen Yu, Xiaojuan Li, Jiaxu Chen   +10 more
wiley   +1 more source

Glycyrrhiza uralensis Fisch. Root-associated microbiota: the multifaceted hubs associated with environmental factors, growth status and accumulation of secondary metabolites

Environmental Microbiome, 2022
Glycyrrhiza uralensis Fisch. is an important, perennial medicinal plant whose root microbiome is considered to play an important role in promoting accumulation of effective medicinal ingredients (liquiritin and glycrrhizic acid).
Chaoyun Chen, Chaofang Zhong, Xi Gao, Chongyang Tan, Hong Bai, Kang Ning   +5 more
doaj   +1 more source