Biomolecules, 2020 While liquiritigenin, isolated from Spatholobus suberectus Dunn, is known to possess anti-inflammatory activities, it still remains to be known whether liquiritigenin has a suppressive effect on T cell activation and T cell-mediated disease.
Eun-Nam Kim +2 more
exaly +3 more sources
The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin
Frontiers in Pharmacology, 2021 The transmembrane 16 (TMEM16) family contains 10 subtypes, and the function of each protein is different. TMEM16A is a calcium-activated chloride channel involved in physiological and pathological situations.
Masataka Sunagawa, Mami Kato
exaly +3 more sources
Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota
Molecules, 2022 The bioavailability of flavonoids is generally low after oral administration. The metabolic transformation of flavonoids by the gut microbiota may be one of the main reasons for this, although these metabolites have potential pharmacological activities ...
Adili Keranmu +2 more
exaly +3 more sources
Liquiritigenin Derivatives and Their Hepatotoprotective Activity
Natural Product Communications, 2010 Liquiritigenin (7,4’-dihydroxyflavanone), isolated from the roots of Glycyrrhiza Glabra , was derivatized to liquiritigenin 7, 4’-diacetate, liquiritigenin 4’-acetate, isoliquiritigenin, and liquiritigenin 7, 4’-dibenzoate.
Karuna Shanker +2 more
exaly +2 more sources
Liquiritigenin reduces osteoclast activity in zebrafish model of glucocorticoid-induced osteoporosis
Journal of Pharmacological Sciences, 2020 Drug and therapies currently used to treat human bone diseases have a lot of severe side effects. Liquiritigenin is a flavonoid extracted from Glycyrrhiza glabra roots which has been reported to have positive effects in vitro on osteoblasts activity and ...
Giuseppe Banfi +2 more
exaly +3 more sources
Genetic structure analysis of Glycyrrhiza species and identification of SNP-loci associated with secondary metabolites in G. glabra [PDF]
BMC GenomicsBackground Glycyrrhiza spp. are medicinal legumes that produce a wide array of pharmacologically active secondary metabolites. This study generated a genomic resource by genotyping-by-sequencing 175 Glycyrrhiza accessions and populations to (1 ...
Ali Moghadam +6 more
doaj +2 more sources
Complete genome sequencing of Lactobacillus pentosus HP-B1718 and identification of the key enzyme for liquiritin biotransformation [PDF]
Frontiers in MicrobiologyIntroductionAs a free aglycone with higher bioavailability and pharmacological activity, liquiritigenin can be obtained from liquiritin (liquiritigenin-4’-O-β-D-glucoside) catalyzed by Aryl-phospho-beta-D-glucosidase (designated as ApgA).
Zhi-Wen Tan +8 more
doaj +2 more sources
Lanthanum enhances biomass and bioactive metabolite production in Glycyrrhiza uralensis via coordinated gene regulation [PDF]
Frontiers in Plant ScienceIntroductionGlycyrrhizic acid, liquiritin, and liquiritigenin are key secondary metabolites in Glycyrrhiza uralensis Fisch. with significant pharmacological value.
Yuanyang Shao +9 more
doaj +2 more sources
Exploring the cytotoxic potential of Artemisia herba-alba crude extract and key phytoconstituents using in vitro assays and molecular docking insights. [PDF]
PLoS ONEThe aim of the current research project is to evaluate the potential cytotoxicity of the aqueous extract of Artemisia -albaherba aerial parts against selected cancer cell lines. The widely grown plant material was collected and extracted.
Lidia Kamal Al-Halaseh +8 more
doaj +2 more sources
Eurotium cristatum Solid-State Fermentation of Burdock Roots: Nutritional Changes, Enhanced Antioxidant Capacity, and Its Association with Phenolic Remodeling [PDF]
AntioxidantsSolid-state fermentation of burdock roots with Eurotium cristatum was performed to enhance their functional properties. Fermentation induced marked compositional remodeling, resulting in a 1.37-fold increase in protein content compared to unfermented ...
Xiaoyu Yang +9 more
doaj +2 more sources