Results 21 to 30 of about 3,770 (149)

Liquiritigenin Ameliorates Rheumatoid Arthritis by Modulating the Nrf2/NF-κB/NLRP3 Pathway in Fibroblast-like Synoviocytes [PDF]

Pharmaceuticals
Background/Objectives: Rheumatoid arthritis (RA) is an autoimmune disorder manifesting as joint destruction and synovial inflammation, with the aberrant activation of fibroblast-like synoviocytes (FLSs) functioning as a critical pathological mechanism ...
Zhuoxi Chen, Nana Chen, Limin Liu, Yingrui Wang, Lejian Zhu, Hui Yang, Zhuqi Han, Xiaoyu Zhang, Shuo Yan, Yuan Du, Leiming Zhang   +10 more
doaj   +2 more sources

Antitumor Study of the Miao Medicine Indigofera stachyodes by Integrating Multiple Chemometrics Network Pharmacology and Experimental Validation [PDF]

Current Issues in Molecular Biology
Indigofera stachyodes Lindl. (I. stachyodes), a fundamental herb in Miao ethnomedicine, possesses a broad pharmacological profile including antitumor potential.
Junhang Zhang, Dan Wang, Qin Nie, Huayong Lou, Yongping Zhang, Jian Xu, Jian Fu   +6 more
doaj   +2 more sources

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models [PDF]

Frontiers in Aging Neuroscience, 2018
The increasing lifespan in developed countries results in age-associated chronic diseases. Biological aging is a complex process associated with accumulated cellular damage by environmental or genetic factors with increasing age.
Mahesh Ramalingam, Hyojung Kim, Yunjong Lee, Yun-Il Lee, Yun-Il Lee   +4 more
doaj   +2 more sources

Exploring the mechanism of guben kechuan granules in the treatment of COPD via network pharmacology, molecular docking and molecular dynamics simulations [PDF]

Scientific Reports
Guben Kechuan granules (GBKC) is a traditional Chinese medicine commonly used to treat chronic obstructive pulmonary disease (COPD), but its mechanism of action has not been fully explained. The aim of our study is to analyse the mechanism of GBKC in the
Wei Li, Miaomiao Yuan, Jinbo Li, Zhangshun Tu, Kaiwang Cui, Yanfang Liao, Hui Liao, Jianping Liu, Xiangwen Gong   +8 more
doaj   +2 more sources

Quantitation of global histone post-translational modifications reveal anti-inflammatory epigenetic mechanisms of liquiritigenin based on the optimized super-SILAC strategy

Frontiers in Cell and Developmental Biology
Liquiritigenin (LIQ) is a dihydroflavonone monomer compound with a planar ring structure that exhibits potent anti-inflammatory activity. The post-translational modifications (PTMs) of histones are closely associated with inflammatory diseases.
Ping Liu, Ping Liu, Jun Zhang, Jun Zhang, Jingdan Zhang, Jingdan Zhang, Yucheng Yuan, Yucheng Yuan, Zhiqing Liu, Sixian Chen, Sixian Chen, Kaifeng Chen, Kaifeng Chen, Li Dong, Zhiyuan Cheng, Zhiyuan Cheng, Yinan Zhang, Meiyu Geng, Meiyu Geng, Minjia Tan, Minjia Tan, Minjia Tan, Minjia Tan, Minjia Tan, Wensi Zhao, Dong Xie   +25 more
doaj   +2 more sources

Multi-Target Mechanisms of Moroccan Aphrodisiac Plants: An Integrative Computational and Phytochemical Investigation. [PDF]

Food Sci Nutr
Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200 
Elrherabi A, Khibech O, Bouhrim M, Laftouhi A, Shahat AA, Alanzi AR, Herqash RN, Basilua JM, Bnouham M.   +8 more
europepmc   +2 more sources

Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation [PDF]

, 2015
Bone is constantly controlled by a balance between osteoblastic bone formation and osteoclastic bone resorption. Liquiritigenin is a plant-derived flavonoid and has various pharmacological effects, such as antioxidative, antitumor, and antiinflammatory ...
Fukuma, Yutaka, Iwatake, Mayumi, Yoneshima, Erika, Uchino, Kaho, Okamoto, Kuniaki, Sakai, Eiko, Tsukuba, Takayuki, Nishishita, Kazuhisa   +7 more
core   +2 more sources

THE EFFECTS OF LIQUIRITIGEN ON THE LUKEMIA INHIBITORY FACTOR RECEPTOR IN GRANULOSA CELLS OF INFERTILE PATIENTS

Sabiad, 2022
Objectives: Granulosa cells have an important role in oocyte nutrition and maturation, oocyte-sperm interaction events such as capacitation, and acrosome reaction.
Emel Usta, Sibel Köktürk, Sibel Doğan, Ayşe Altun, Sibel Bulgurcuoğlu Kuran, Feride Özdemir   +5 more
doaj   +1 more source

Glycyrrhiza Flavonoids Promote Osteoblast Proliferation and Differentiation by Activating Runx2 via the PI3K/AKT Signaling Pathway [PDF]

Shipin Kexue
In order to clarify the mechanism of action of licorice flavonoids in alleviating bone loss caused by osteoporosis, this study compared the effects of four glycyrrhiza flavonoids, naringenin, liquiritigenin, isoliquiritigenin, and licochalcone A, on ...
CHU Hongdan, LIANG Zheng, XU Jingru, WANG Zhenhua, LI Gang, GAN Jing, XU Bo
doaj   +1 more source

Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways

, 2023
Oxidative stress plays a critical role in drug-induced liver injury. In recent years, liquiritigenin (LQ), a natural flavonoid distributed in Glycyrrhizae Radix et Rhizoma (Gan Cao), shows protective effects against oxidative hepatotoxicity. However, the
Zongfang Li (455427), Mengjiao Shi (3696739), Dongmei Ren (2095411), Pengfei Liu (136115), Yaping Zhao (1341456), Rongrong Liu (513050), Miaomiao Li (483829), Ying Guo (53523), Jiayi Xu (2287153), Jian Zhang (1682)   +9 more
core   +2 more sources