Results 221 to 230 of about 53,833 (282)

[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells. [PDF]

Mol Med Rep
Cao LQ, Wang YN, Liang M, Pan MZ.
europepmc   +1 more source

A Multistrategy AI‐Assisted Consensus Screening Pipeline for Discovery of Candidate p53 Monomer Binders

Advanced Intelligent Discovery, EarlyView.
An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li, Xueyi Liu, Qiuyue Li, Chengfeng Yue, Xin Li, Yugang Huang, Xin Deng, Junfei Zhang, Xue Liang, Guodong Ye   +9 more
wiley   +1 more source

Real-world immune dynamics following COVID-19 vaccination and breakthrough infection: a paired-sample study in Zhejiang Province, China. [PDF]

Front Immunol
Hu Y, Weng Y, Li X, Huang Y, Pan J, Wu Y, Liao R, Gong R, Zhao L, Zhang D, Han M, Xu Y, Zheng X, Lu S, Kong Q, Chen E.   +15 more
europepmc   +1 more source

Energy‐Aware Perturbation Optimization for Memristor‐Array Convolutional Neural Networks

Advanced Intelligent Systems, EarlyView.
Memristor‐array inference becomes more energy efficient when layer inputs are reshaped before computation. Sinusoidal perturbation encoding with dual‐threshold screening reduces active voltage pulses and contracts ADC input‐current ranges, jointly lowering crossbar and peripheral energy while preserving accuracy across hardware MNIST validation, deep ...
Ao Xu, Lun Lu, Youpeng Wu, Yao Guo, Yi Li, Yinan Wang, Qingjiang Li   +6 more
wiley   +1 more source

Effects of empagliflozin on cardiac function and cardiorespiratory fitness in people with type 2 diabetes: a randomised controlled trial. [PDF]

Cardiovasc Diabetol Endocrinol Rep
Nanayakkara N, Huang MLH, La Gerche A, Kaye DM, Cooper ME, Esler MD, Reutens AT, Shaw JE, Jenkins A, Cohen ND.   +9 more
europepmc   +1 more source

How cold is too cold? A theoretical analysis of the optimal trigger for index insurance for frost damage to crops

American Journal of Agricultural Economics, EarlyView.
Abstract Crop insurance is undoubtedly an extremely valuable element in protecting agricultural businesses, but in many cases standard indemnity‐based products have had very low uptake due to high transaction costs elevating premiums to unaffordable levels.
Amogh Prakasha Kumar, Laura Meriluoto, Richard Watt   +2 more
wiley   +1 more source

Environmental Preferences and Functional Variations of Methanotrophs in Northeast Qinghai-Tibet Plateau Wetlands. [PDF]

Environ Microbiol Rep
He K, Zhao J, Pan J, Zhang Q, Yang S, Feng H.   +5 more
europepmc   +1 more source

Linking community structure and climate vulnerability in desert plant assemblages of southern California

American Journal of Botany, EarlyView.
Abstract Premise Desert plant assemblages in southern California provide an opportunity to link patterns of community structure with climate‐driven vulnerability in a rapidly changing environment. California sustains an exceptionally diverse flora of approximately 4300 plant species, with 31% identified as endemic.
Hector Zumbado‐Ulate, Luis E. Barrios, Danelle A. Baronia, G. Darrel Jenerette, Lynn C. Sweet   +4 more
wiley   +1 more source

Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior. [PDF]

Matrix Biol
Guillard J, Stradley J, Turan K, Storl-Desmond MR, Lin S, Huang YC, Forti KM, Weber CR, Schwӧrer S.   +8 more
europepmc   +1 more source