Results 1 to 10 of about 21,385 (242)

Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. [PDF]

PLoS ONE, 2012
Mutations in low-density lipoprotein receptor-related protein 5 (Lrp5) impair retinal angiogenesis in patients with familial exudative vitreoretinopathy (FEVR), a rare type of blinding vascular eye disease.
Jing Chen, Andreas Stahl, Nathan M Krah, Molly R Seaward, Jean-Sebastian Joyal, Aimee M Juan, Colman J Hatton, Christopher M Aderman, Roberta J Dennison, Keirnan L Willett, Przemyslaw Sapieha, Lois E H Smith   +11 more
doaj   +22 more sources

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence [PDF]

Frontiers in Cell and Developmental Biology, 2021
The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren, Jiongcheng Chen, Youhua Liu, Youhua Liu   +3 more
doaj   +4 more sources

Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry

Therapeutics and Clinical Risk Management, 2021
Masaki Nakano,1,* Haruka Yui,1,* Shingo Kikugawa,2 Ryosuke Tokida,3 Noriko Sakai,4 Naoki Kondo,5 Naoto Endo,5 Hirotaka Haro,6 Hiroki Shimodaira,1 Takako Suzuki,1,7 Hiroyuki Kato,1 Jun Takahashi,1 Yukio Nakamura1 1Department of Orthopaedic Surgery,
Nakano M, Yui H, Kikugawa S, Tokida R, Sakai N, Kondo N, Endo N, Haro H, Shimodaira H, Suzuki T, Kato H, Takahashi J, Nakamura Y   +12 more
doaj   +3 more sources

Development of the Bone Phenotype and microRNA Profile in Adults With Low‐Density Lipoprotein Receptor‐Related Protein 5–High Bone Mass (LRP5‐HBM) Disease [PDF]

JBMR Plus, 2021
Pathogenic variants in the Wnt‐pathway co‐receptor low‐density lipoprotein (LDL) receptor‐related protein 5 (LRP5) cause high bone mass (LRP5‐HBM) due to insensitivity to the endogenous antagonist of Wnt‐signaling.
Jens‐Jacob Lindegaard Lauterlein, Fatma Gossiel, Moritz Weigl, Richard Eastell, Matthias Hackl, Pernille Hermann, Jens Bollerslev, Morten Frost   +7 more
doaj   +2 more sources

LRP5: A Multifaceted Co-Receptor in Development, Disease, and Therapeutic Target [PDF]

Cells
Low-density lipoprotein receptor-related protein 5 (LRP5) is a multifunctional transmembrane coreceptor that plays a pivotal role in development and disease.
Abdulmajeed F. Alrefaei
doaj   +2 more sources

Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia. [PDF]

PLoS ONE, 2015
The low density lipoprotein receptor-related protein-5 (LRP5), a co-receptor in the Wnt signaling pathway, modulates bone mass in humans and in mice. Lrp5 knock-out mice have severely impaired responsiveness to mechanical stimulation whereas Lrp5 gain-of-
Paul J Niziolek, Whitney Bullock, Matthew L Warman, Alexander G Robling   +3 more
doaj   +3 more sources

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity [PDF]

Communications Medicine
Background WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass ...
Nellie Y. Loh, Senthil K. Vasan, Daniel B. Rosoff, Emile Roberts, Andrea D. van Dam, Manu Verma, Daniel Phillips, Agata Wesolowska-Andersen, Matt J. Neville, Raymond Noordam, David W. Ray, Jonathan H. Tobias, Celia L. Gregson, Fredrik Karpe, Constantinos Christodoulides   +14 more
doaj   +2 more sources

Pathway-Informed Machine Learning Identifies Genetic Predictors of High-Dose Methotrexate-Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia. [PDF]

Clin Pharmacol Ther
High‐dose methotrexate for pediatric cancer treatment is frequently associated with mucositis, which can lead to delayed or discontinued treatment and impact survival. While individual genetic variants have been implicated, the cumulative impact of genetic variation within relevant biological pathways remains unexplored.
Zhang XYC, Scott EN, Maagdenberg H, Man A, Li KH, Rassekh SR, Carleton BC, Ross CJD, Wasserman WW, Loucks CM.   +9 more
europepmc   +2 more sources

LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. [PDF]

PLoS ONE, 2012
Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood.
Tadanori Mammoto, Jing Chen, Elisabeth Jiang, Amanda Jiang, Lois E Smith, Donald E Ingber, Akiko Mammoto   +6 more
doaj   +6 more sources

New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction [PDF]

Frontiers in Endocrinology, 2015
Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj   +5 more sources