LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. [PDF]
PLoS ONE, 2012 Angiogenesis is crucial for lung development. Although there has been considerable exploration, the mechanism by which lung vascular and alveolar formation is controlled is still not completely understood.
Tadanori Mammoto +6 more
doaj +8 more sources
Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. [PDF]
PLoS ONE, 2012 Mutations in low-density lipoprotein receptor-related protein 5 (Lrp5) impair retinal angiogenesis in patients with familial exudative vitreoretinopathy (FEVR), a rare type of blinding vascular eye disease.
Jing Chen +11 more
doaj +22 more sources
LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity [PDF]
Communications MedicineBackground WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism, alongside high bone mass ...
Nellie Y. Loh +14 more
doaj +2 more sources
New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction [PDF]
Frontiers in Endocrinology, 2015 Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj +5 more sources
LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]
PLoS Pathogens, 2007 Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young +8 more
doaj +3 more sources
International Journal of Polymer Science, 2019 Low-density lipoprotein receptor-related protein 5 (LRP5) plays a vital role in bone formation and regeneration. In this study, we developed an injectable and sustained-release composite loading LRP5 which could gelatinize in situ.
Yanhai Xi +8 more
doaj +2 more sources
Case report: exome sequencing identified mutations in the LRP5 and LGR4 genes in a case of osteoporosis with recurrent fractures and extraskeletal manifestations [PDF]
Frontiers in EndocrinologyBackgroundGenetic mutations have been reported in a number of bone disorders with or without extra-skeletal manifestations. The purpose of the present study was to investigate the genetic cause in a middle-aged woman with osteoporosis, recurrent ...
Poonam Mehta +11 more
doaj +2 more sources
Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation
Frontiers in Endocrinology, 2022 Low-density Lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis.
Iryna Khrystoforova +8 more
doaj +1 more source
Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation and apoptosis in a cell autonomous manner. [PDF]
PLoS ONE, 2012 Although Lrp5 is known to be an important contributor to the mechanisms regulating bone mass, its precise role remains unclear. The aim of this study was to establish whether mutations in Lrp5 are associated with differences in the growth and/or ...
Behzad Javaheri +6 more
doaj +1 more source
LRP5 is required for vascular development in deeper layers of the retina. [PDF]
PLoS ONE, 2010 The low-density lipoprotein receptor-related protein 5 (LRP5) plays an important role in the development of retinal vasculature. LRP5 loss-of-function mutations cause incomplete development of retinal vessel network in humans as well as in mice.
Chun-hong Xia +2 more
doaj +1 more source