Results 91 to 100 of about 21,385 (242)

Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes [PDF]

, 2014
Canonical Wnt signaling is initiated by the binding of Wnt proteins to their receptors, low-density lipoprotein-related protein 5 and 6 (LRP5/6) and frizzled proteins, leading to phosphatidylinositol (4,5)bisphosphate (PtdIns(4,5)P2) production ...
Jones, Sara A., Kim, Ingyu, Pan, Weijun, Wu, Dianqing, Zhang, Youxin, Zhuang, Xiaowei   +5 more
core   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Bone Research, 2021
Mechanical loading to the bone is known to be beneficial for bone homeostasis and for suppressing tumor-induced osteolysis in the loaded bone. However, whether loading to a weight-bearing hind limb can inhibit distant tumor growth in the brain is unknown.
Yao Fan, Rongrong Zha, Tomohiko Sano, Xinyu Zhao, Shengzhi Liu, Mark D. Woollam, Di Wu, Xun Sun, Kexin Li, Motoki Egi, Fangjia Li, Kazumasa Minami, Amanda P. Siegel, Takashi Horiuchi, Jing Liu, Mangilal Agarwal, Akihiro Sudo, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota   +19 more
doaj   +1 more source

Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]

, 2014
The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien, Huysseune, Ann, Soenens, Mieke   +2 more
core   +3 more sources

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, Volume 13, Issue 5, 27 January 2026.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Fabrication of Fructooligosaccharide‐Larimichthys crocea Peptide Copolymer by Wet‐Heating for Enhanced Calcium Delivery and Bone‐Lipid Metabolism Regulation

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
A food‐derived fructooligosaccharide‐Larimichthys crocea peptide (FOS‐LCP) copolymer was prepared by wet‐heating and exhibited high calcium‐binding capacity and enhanced intestinal calcium uptake compared with native peptides. In bone marrow mesenchymal stem cells from calcium‐deficient mice, FOS‐LCP was found to promote osteogenesis while suppressing ...
Chunlei Liu, Xiaoping Wu, Yihang Guo, Dan Li   +3 more
wiley   +1 more source

PCSK9 and LRP5 in macrophage lipid internalization and inflammation

Cardiovascular Research, 2020
Abstract Aims Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. Low-density lipoprotein receptors (LDLR) play a critical role in regulating blood cholesterol levels by binding to and clearing LDLs from the circulation ...
Lina Badimon, Aureli Luquero, Javier Crespo, Esther Peña, Maria Borrell-Pages   +4 more
openaire   +3 more sources

Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]

, 2012
Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon, Fernsebner, Katharina, Geissler, Claudia, Jochum, Marianne, Kolben, Thomas, Lechner, Felix, Neth, Peter, Peroebner, Iris, Ruiz-Heinrich, Lourdes   +8 more
core   +2 more sources

Oral Delivery of R‐spondin1‐Loaded Small Extracellular Vesicles Activates WNT Signalling Pathway to Accelerate Intestinal Injury Repair and Reverse Ageing

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Yang et al. demonstrated that HSPG mediate the loading of active R‐spondin1 protein onto the surface of small extracellular vesicles (evRSPO1). evRSPO1 induced WNT/β‐catenin activity in intestinal organoids and tissues, thereby regulating intestinal stem cells proliferation.
Lingyan Yang, Xu Wang, Xiyang Wei, Pei Yu, Yue Liu, Shixiang Wang, Yuefang Lin, Yue Yang, Ting Jiang, Zhiping Qiao, Jiaxiang Zhang, Shicheng Yu, Ye‐Guang Chen, Yun‐Shen Chan   +13 more
wiley   +1 more source

Wnt5a Signaling in Normal and Cancer Stem Cells. [PDF]

, 2017
Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner.
Kipps, Thomas J, Zhang, Suping, Zhou, Yan   +2 more
core   +2 more sources