Results 101 to 110 of about 20,422 (245)

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, Volume 12, Issue 24, June 26, 2025.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

PTH Stimulates Bone Formation in Mice Deficient in Lrp5 [PDF]

Journal of Bone and Mineral Research, 2007
Abstract Lrp5 deficiency decreases bone formation and results in low bone mass. This study evaluated the bone anabolic response to intermittent PTH treatment in Lrp5-deficient mice. Our results indicate that Lrp5 is not essential for the stimulatory effect of PTH on cancellous and cortical bone formation. Introduction: Low-
Jeff Liu, Urszula T. Iwaniec, Mercedes F. Rivera, Gwenn M. Hansen, Thomas J. Wronski, Robert Brommage, Rosemarie R Arzaga   +6 more
openaire   +3 more sources

Low-density lipoprotein receptor–related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction [PDF]

, 2014
INTRODUCTION: Wnt ligands bind to low-density lipoprotein receptor–related protein (LRP) 5 or 6, triggering a cascade of downstream events that include β-catenin signaling.
Jang-Soo Chun, Je-Hwang Ryu, Jeong-Tae Koh, Ka Park, Kieun Kim, Suyeon Kim, Youngnim Shin, Yun Huh   +7 more
core   +1 more source

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications

npj Precision Oncology
Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes.
Bhasker Dharavath, Ashwin Butle, Akshita Chaudhary, Ankita Pal, Sanket Desai, Aniket Chowdhury, Rahul Thorat, Pawan Upadhyay, Sudhir Nair, Amit Dutt   +9 more
doaj   +1 more source

Elucidating the Molecular Landscape of Cystic Kidney Disease: Old Friends, New Friends and Some Surprises

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT Cystic kidney diseases (CyKD) are a diverse group of disorders affecting more than 1 in 1000 individuals. Over 120 genes are implicated, primarily encoding components of the primary cilium, transcription factors, and morphogens. Prognosis varies greatly by molecular diagnosis. Causal variants are not identified in 10%–60% of individuals due to
Deborah Watson, Frank Mentch, Jonathan Billings, Kayleigh Ostberg, Michael E. March, Jennifer M. Kalish, Dong Li, India Cannon, Lisa M. Guay‐Woodford, Erum Hartung, Alanna Strong   +10 more
wiley   +1 more source

LRP5, Bone Density, and Mechanical Stress: A Case Report and Literature Review

Frontiers in Endocrinology, 2019
The Wnt-β-catenin pathway receptor, low-density lipoprotein receptor-related protein 5 (LRP5), is a known regulator of bone mineral density. It has been hypothesized that specific human polymorphisms in LRP5 impact bone density, in part, by altering the ...
Nicholas G. Norwitz, Nicholas G. Norwitz, Adrian Soto Mota, Madhusmita Misra, Madhusmita Misra, Madhusmita Misra, Kathryn E. Ackerman, Kathryn E. Ackerman, Kathryn E. Ackerman   +8 more
doaj   +1 more source

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background The Wnt/β‐catenin pathway and its bone‐specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events, particularly
Bingna Zhou, Jing Hu, Yuanyuan Yu, Lei Sun, Yanye Wang, Qian Zhang, Yan Jiang, Ou Wang, Xiaoping Xing, Weibo Xia, Luyao Wang, Ge Zhang, Mei Li   +12 more
wiley   +1 more source

Patient care practices for LGBTQ+ individuals in clinical genetics: A scoping review

Journal of Genetic Counseling, Volume 34, Issue 3, June 2025.
Abstract Individuals who are LGBTQ+ (Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, and/or have a sexual orientations and/or gender identity beyond cisheteronormative conceptions) face systemic barriers to healthcare, leading to significant health inequities. To address these challenges, genetic providers must better understand and inclusively
Kimberly Zayhowski, Kayla Horowitz, Molly Bostrom, Kathleen F. Mittendorf, Megan Kocher, Jehannine (J9) Austin, Ian M. MacFarlane   +6 more
wiley   +1 more source

Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity

BMC Medical Genetics, 2012
Background Primary osteoporosis is a rare childhood-onset skeletal condition whose pathogenesis has been largely unknown. We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lipoprotein ...
Korvala Johanna, Jüppner Harald, Mäkitie Outi, Sochett Etienne, Schnabel Dirk, Mora Stefano, Bartels Cynthia F, Warman Matthew L, Deraska Donald, Cole William G, Hartikka Heini, Ala-Kokko Leena, Männikkö Minna   +12 more
doaj   +1 more source