Results 101 to 110 of about 21,385 (242)

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study. [PDF]

, 2018
The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β ...
A Guadalupe-Grau, A Liedert, A Nattiv, A Nott, A. D. Flouris, AF Doyle-Lucas, AS Brazeau, C George, C Kesavan, C. Durães, DG Monroe, DG Winkler, E Twitchett, EA Twitchett, EM Kirchner, F. Marques, G. S. Metsios, H Li, IP Braidman, J Delgado-Calle, J Majewski, J Xu, J. C. Machado, J. Maia, JC Gibbs, JH Tobias, JP Bonjour, K Lee, KJ Jepsen, KL Scofield, KM Khan, L Maïmoun, L Maïmoun, L Pietro Di, L. Nogueira, LF Bonewald, LF Bonewald, M Mountjoy, M Suuriniemi, M-SM Ardawi, M. Wyon, MK Torstveit, N a Georgopoulos, N Pollock, N. Adubeiro, P Burckhardt, PB Crawford, PS Hinton, R Valentino, RW Kleposki, S Wheatley, T Amorim, T Amorim, T Amorim, T. Amorim, TL Robinson, W Xing, WF Li, X Tu, Y. Koutedakis   +59 more
core   +2 more sources

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, Volume 10, Issue 2, 22 January 2026.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

LRP5, Bone Density, and Mechanical Stress: A Case Report and Literature Review

Frontiers in Endocrinology, 2019
The Wnt-β-catenin pathway receptor, low-density lipoprotein receptor-related protein 5 (LRP5), is a known regulator of bone mineral density. It has been hypothesized that specific human polymorphisms in LRP5 impact bone density, in part, by altering the ...
Nicholas G. Norwitz, Nicholas G. Norwitz, Adrian Soto Mota, Madhusmita Misra, Madhusmita Misra, Madhusmita Misra, Kathryn E. Ackerman, Kathryn E. Ackerman, Kathryn E. Ackerman   +8 more
doaj   +1 more source

Genetic evidence that SOST inhibits WNT signaling in the limb [PDF]

, 1987
SOST is a negative regulator of bone formation, and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically.
Collette, Nicole M., Genetos, Damian C., Murugesh, Deepa, Harland, Richard M., Loots, Gabriela G.   +4 more
core   +1 more source

Development of the neurohypophysis: A major neuroendocrine interface

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh, Naveen Nedunchezhian, Md Hasan Ali, Sebastian Pęcherz, Natalia Kowalewska, Savani Anbalagan   +5 more
wiley   +1 more source

LRP5/canonical Wnt signalling and healing of ischemic myocardium

Basic Research in Cardiology, 2016
LRP5 (low-density lipoprotein receptor-related protein 5) activates canonical Wnt signalling. LRP5 plays multiple roles including regulation of lipoprotein and cholesterol homeostasis as well as innate immunity cell function. However, it is not known whether LRP5 has a role in the myocardium.
M. Borrell-Pages, G. Vilahur, J. C. Romero, L. Casaní, M. T. Bejar, L. Badimon   +5 more
openaire   +3 more sources

An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear [PDF]

, 2011
Sensory hair cells of the inner ear are the mechano-electric transducers of sound and head motion. In mammals, damage to sensory hair cells leads to hearing or balance deficits.
Alvarado, David M, Bashiardes, Stavros, Hawkins, R. D, Ku, Yuan-Chieh, Lovett, Michael, Powder, Kara E, Speck, Judith D, Spriggs, Meghan K, Veile, Rose A, Warchol, Mark E   +9 more
core   +2 more sources

Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal Dystrophies in 144 Consanguineous Pakistani Families. [PDF]

, 2017
PurposeThe Pakistan Punjab population has been a rich source for identifying genes causing or contributing to autosomal recessive retinal degenerations (arRD).
Akram, Javed, Ayyagari, Radha, Cabrera, Patricia E, Chen, Jianjun, Chen, Yabin, Govindarajan, Gowthaman, Gupta, Nikhil, Hejtmancik, J Fielding, Huang, Li, Jiang, Dan, Jiao, Xiaodong, Jin, Chongfei, Khan, Shaheen N, Li, Jiali, Li, Lin, M'hamdi, Oussama, Ma, Xiaoyin, Ma, Yan, Ma, Zhiwei, Naeem, Muhammad Asif, Riazuddin, S Amer, Riazuddin, Sheikh, Sieving, Paul A, Sun, Wenmin, Tanwar, Mukesh   +24 more
core   +1 more source

Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications

npj Precision Oncology
Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes.
Bhasker Dharavath, Ashwin Butle, Akshita Chaudhary, Ankita Pal, Sanket Desai, Aniket Chowdhury, Rahul Thorat, Pawan Upadhyay, Sudhir Nair, Amit Dutt   +9 more
doaj   +1 more source