Results 111 to 120 of about 21,385 (242)
The role of axin in the degradation of B-catenin in human oesophageal squamous cell carcinoma [PDF]
, 2009 Axin, in combination with adenomatous polyposis coli (APC), forms the scaffold of the β-catenin degradation-targeting complex. Intricate interactions within this complex lead to the phosphorylation and subsequent ubiquitination of β-catenin, followed ...
Bezuidenhout, Belinda Catherine
core
Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
BMC Medical Genetics, 2012 Background Primary osteoporosis is a rare childhood-onset skeletal condition whose pathogenesis has been largely unknown. We have previously shown that primary osteoporosis can be caused by heterozygous missense mutations in the Low-density lipoprotein ...
Korvala Johanna +12 more
doaj +1 more source
Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling [PDF]
, 2011 Sclerostin is an extracellular negative regulator of bone formation that is a recognized therapeutic target for osteoporosis therapy. In the present study, we performed DNA aptamer selection against sclerostin, then characterized aptamer-sclerostin ...
Chan, C, Leung, CM, Shum, KT, Tanner, JA
core +1 more source
Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women [PDF]
, 2005 Daniel L. Koller +11 more
openalex +1 more source
Fzd7-Lrp5/6 In Hydrostatic Pressure Upregulated Chondrogenesis Of Bmscs
International Dental JournalAim or purpose: To detect the expression of Frizzled (FZD) 7-low-density lipoprotein receptor-related protein (LRP) 5/6 complex and chondrogenic marker genes in BMSCs under different mechanical environments.
Baixiang Cheng +6 more
doaj +1 more source
SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease
Journal of Osteoporosis, 2010 The study of rare human genetic disorders has often led to some of the most significant advances in biomedical research. One such example was the body of work that resulted in the identification of the Low Density Lipoprotein-Related Protein (LRP5) as a ...
James J. Mason, Bart O. Williams
doaj +1 more source
Archives of Endocrinology and MetabolismObjective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population.
Karla Simone Costa de Souza +11 more
doaj +1 more source
PLoS ONE, 2019 Mechanical loading is essential for the maintenance of musculoskeletal homeostasis. Cartilage has been demonstrated to be highly mechanoresponsive, but the mechanisms by which chondrocytes respond to mechanical stimuli are not clearly understood.
Rachel C Nordberg +4 more
doaj +1 more source
Cajanolactone A from Cajanus cajan Promoted Osteoblast Differentiation in Human Bone Marrow Mesenchymal Stem Cells via Stimulating Wnt/LRP5/β-Catenin Signaling [PDF]
, 2019 Shan Liu +8 more
openalex +1 more source