Results 111 to 120 of about 20,422 (245)

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]

, 2018
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar, A Trinh, AJ Copp, AJ Copp, AS Findlay, B Wang, BA Alman, C Cooper, C Hartmann, CF Davey, CH Chen, D Karasik, D Szklarczyk, DG Winkler, DJ Epstein, DM Juriloff, E Canalis, E Nikolopoulou, EM Curtis, GH Li, GL Galea, GL Galea, GL Galea, GL Galea, H Marreiros, H Yin, HF Zheng, IR Orriss, IR Orriss, JK Morris, JN Murdoch, K Estrada, KC Keller, KS Joeng, L D’Andrea, LJ Martin, LL Yates, LL Yates, M Akbar, M Kalogeropoulos, ME Ross, MJ Anderson, MJ Harris, MJ Harris, MR Dohn, NC Nowlan, P Andre, P Elms, P Ybot-Gonzalez, P Ybot-Gonzalez, R Klootwijk, R Xu, S Babayeva, S Li, S Maere, SA Brown, SE Taylor, SJ Conway, T Dodge, T Yang, UM Ayturk, V Martinelli, W Yang, Y Erdem, Y Koyabu, Y Lei, Z Kibar   +66 more
core   +3 more sources

The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus

Archives of Endocrinology and Metabolism
Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population.
Karla Simone Costa de Souza, Marcela Abbott Galvão Ururahy, Yonara Monique da Costa Oliveira, Melina Bezerra Loureiro, Heglayne Pereira Vital da Silva, Raul Hernandes Bortolin, André Ducati Luchessi, Ricardo Fernando Arrais, Rosário Dominguez Crespo Hirata, Maria das Graças Almeida, Mário Hiroyuki Hirata, Adriana Augusto de Rezende   +11 more
doaj   +1 more source

WNT-mediated Modulation of Bone Metabolism: Implications for WNT Targeting to Treat Extraskeletal Disorders [PDF]

, 2017
The WNT-signaling pathway is involved in cellular and tissue functions that control such diverse processes as body axis patterning, cellular proliferation, differentiation, and life span.
Bullock, Whitney A., Robling, Alexander G.   +1 more
core   +1 more source

SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease

Journal of Osteoporosis, 2010
The study of rare human genetic disorders has often led to some of the most significant advances in biomedical research. One such example was the body of work that resulted in the identification of the Low Density Lipoprotein-Related Protein (LRP5) as a ...
James J. Mason, Bart O. Williams
doaj   +1 more source

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]

, 2016
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja, Lechpammer, Mirna, Pećina-Šlaus, Nives   +2 more
core   +2 more sources

A Study of the Relationship between the Polymorphism and Mutation of rs682429 and rs3781590 in the LRP5 Gene and Bone Metabolism in Postmenopausal Type 2 Diabetic Women in Xinjiang

Journal of Diabetes Research, 2020
Objective. To explore the expression of the polymorphism and mutation of rs682429 and rs3781590 in the low-density lipoprotein receptor-related protein 5 (LRP5) genotype and to analyse the relationship of bone mineral density (BMD) and bone metabolism ...
Jun Li, SiYuan Li, HuiRong Zhao, JiaJia Li, Shuang Wang, YanQiu Shi   +5 more
doaj   +1 more source

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. [PDF]

, 2013
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emerging as key regulatory proteins with great promise as therapeutic agents for bone disorders.
Collette, Nicole, Economides, Aris, Gale, Nicholas, HARLAND, Richard M., Loots, Gabriela, Murugesh, Deepa, Sebastian, Aimy, Taher, Leila, Yee, Cristal   +8 more
core   +1 more source

LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure.

PLoS ONE, 2019
Mechanical loading is essential for the maintenance of musculoskeletal homeostasis. Cartilage has been demonstrated to be highly mechanoresponsive, but the mechanisms by which chondrocytes respond to mechanical stimuli are not clearly understood.
Rachel C Nordberg, Liliana F Mellor, Andrew R Krause, Henry J Donahue, Elizabeth G Loboa   +4 more
doaj   +1 more source

Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]

, 2014
The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien, Huysseune, Ann, Soenens, Mieke   +2 more
core   +3 more sources

Expression of the Type I Diabetes-associated Gene LRP5 in Macrophages, Vitamin A System Cells, and the Islets of Langerhans Suggests Multiple Potential Roles in Diabetes [PDF]

, 2000
David J. Figueroa, J. Fred Hess, Bonnie Ky, Sheryl D. Brown, Volker Sandig, Anne Hermanowski‐Vosatka, Rebecca C.J. Twells, John A. Todd, Christopher P. Austin   +8 more
openalex   +1 more source