Results 121 to 130 of about 20,422 (245)

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor [PDF]

, 2002
Masaki Kato, Millan S. Patel, Régis Levasseur, Ivan B. Lobov, Benny Hung‐Junn Chang, Donald A. Glass, Christine Hartmann, Lan Li, Tae-Ho Hwang, Cory Brayton, Richard A. Lang, Gérard Karsenty, Lawrence Chan   +12 more
openalex   +1 more source

LRP5 and bone mass regulation: Where are we now? [PDF]

BoneKEy Reports, 2012
The discovery of causal mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene underlying conditions of altered bone mass ushered in a new era in bone research. Since those original publications, the role of Lrp5 and the Wnt/β-catenin signaling pathway controlled by Lrp5 and its homologs, Lrp6 and Lrp4, in bone mass regulation ...
openaire   +3 more sources

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

eLife, 2019
Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.
Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu   +14 more
doaj   +1 more source

The role of axin in the degradation of B-catenin in human oesophageal squamous cell carcinoma [PDF]

, 2009
Axin, in combination with adenomatous polyposis coli (APC), forms the scaffold of the β-catenin degradation-targeting complex. Intricate interactions within this complex lead to the phosphorylation and subsequent ubiquitination of β-catenin, followed ...
Bezuidenhout, Belinda Catherine
core  

Autosomal Recessive Familial Exudative Vitreoretinopathy Is Associated with Mutations in LRP5 [PDF]

, 2004
Xiaodong Jiao, V. Ventruto, Michael T. Trese, Barkur S. Shastry, J. Fielding Hejtmancik   +4 more
openalex   +1 more source

LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments

Nature Communications
Polyunsaturated fatty acids (PUFAs), which cannot be synthesized by animals and must be supplied from the diet, have been strongly associated with human health. However, the mechanisms for their accretion remain poorly understood.
Wenwen Tang, Yi Luan, Qianying Yuan, Ao Li, Song Chen, Stanley Menacherry, Lawrence Young, Dianqing Wu   +7 more
doaj   +1 more source

LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density [PDF]

, 2004
Takeshi Mizuguchi, Itsuko Furuta, Yukio Watanabe, Kazuhiro Tsukamoto, Hiroshi Tomita, Mitsuhiro Tsujihata, Tohru Ohta, Tatsuya Kishino, Naomichi Matsumoto, Hisanori Minakami, Norio Niikawa, Koh-ichiro Yoshiura   +11 more
openalex   +1 more source

Gene–gene interaction and association of Wnt/Β-catenin signalling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population

Autoimmunity, 2019
Objectives: To explore the genetic interaction between Wnt/β-catenin signalling pathway genes and ankylosing spondylitis (AS) in the Chinese population.
Rui Liu, Xu Zhang, Guangming Jiang, Yubo Ma, Jiajia Yang, Meng Wu, Renfang Han, Mengya Chen, Yaping Yuan, Xingxing Hu, Meijuan Pan, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Yanfeng Zou, Guixia Pan, Faming Pan   +16 more
doaj   +1 more source

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor [PDF]

, 2005
Mikhail A. Semenov, Keiko Tamai, Xi He
openalex   +1 more source

Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women [PDF]

, 2005
Daniel L. Koller, Shoji Ichikawa, Michelle L. Johnson, Dongbing Lai, Xiaoling Xuei, Howard J. Edenberg, P. Michael Conneally, Siu L. Hui, C. Conrad Johnston, Munro Peacock, Tatiana Foroud, Michael J. Econs   +11 more
openalex   +1 more source