Results 11 to 20 of about 20,422 (245)
eys+/-; lrp5+/− Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle [PDF]
iScience, 2020 Summary: Vision is essential for vertebrates including humans. Sustained vision is accomplished by retinoid metabolism, the “visual cycle,” where all-trans retinol (atROL) is incorporated into the retinal pigment epithelium (RPE) from photoreceptors ...
Shimpei Takita, Yuko Seko
doaj +3 more sources
LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence [PDF]
Frontiers in Cell and Developmental Biology, 2021 The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren +3 more
doaj +4 more sources
Lrp5 functions in bone to regulate bone mass [PDF]
Nature Medicine, 2011 The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in humans.
Yajun Cui +22 more
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LRP5 gene polymorphisms and idiopathic osteoporosis in men
Bone, 2005 Mutations in the low-density lipoprotein receptor-related protein 5 gene (LRP5) have demonstrated the role of LRP5 in bone mass acquisition. LRP5 variants were recently reported to contribute to the population-based variance in vertebral bone mass and size in males. To investigate whether LRP5 variants are implicated in idiopathic male osteoporosis, we
Serge Ferrari +7 more
openalex +5 more sources
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd [PDF]
Molecular and Cellular Biology, 2004 The mechanism by which the high-bone-mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling was investigated. The mutation was previously shown to reduce DKK1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for DKK-mediated antagonism.
Junhao Mao +9 more
openaire +3 more sources
LRP5 and LRP6 in development and disease [PDF]
Trends in Endocrinology & Metabolism, 2013 Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions ...
Bart O. Williams +4 more
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LRP5 variants may contribute to ADPKD [PDF]
European Journal of Human Genetics, 2015 Mutations in Polycystic Kidney Disease proteins (PKD1 or PKD2) are causative for autosomal dominant polycystic kidney disease (ADPKD). However, a small subset of ADPKD probands do not harbor a mutation in any of the known genes. Low density lipoprotein Receptor-related Protein 5 (LRP5) was recently associated with hepatic cystogenesis in isolated ...
Carsten Bergmann +12 more
openaire +5 more sources
LRP5 gene polymorphism and cortical bone [PDF]
Aging Clinical and Experimental Research, 2010 There is evidence that distinct genetic polymorphisms of LRP5 are associated with low Bone Mineral Density (BMD) and the risk of fracture. However, relationships between LRP5 polymorphisms and micro- and macro architectural bone characteristics assessed by pQCT have not been studied.
F. Lauretani +14 more
openaire +5 more sources
The Effect of Overexpression of Lrp5 on the Temporomandibular Joint [PDF]
CARTILAGE, 2020 Objective The temporomandibular joint (TMJ) is a unique fibrocartilaginous joint that adapts to mechanical loading through cell signaling pathways such as the Wnt pathway. Increased expression of low-density lipoprotein receptor-related protein 5 (Lrp5), a co-receptor of the Wnt pathway, is associated with a high bone mass (HBM) phenotype.
Achint Utreja +4 more
openalex +3 more sources
LRP5 sequence and polymorphisms in the baboon [PDF]
Journal of Medical Primatology, 2009 AbstractBackground LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with other non‐human primates has not been performed ...
Michael C. Mahaney +5 more
openaire +3 more sources