eys+/-; lrp5+/− Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle [PDF]
iScience, 2020 Summary: Vision is essential for vertebrates including humans. Sustained vision is accomplished by retinoid metabolism, the “visual cycle,” where all-trans retinol (atROL) is incorporated into the retinal pigment epithelium (RPE) from photoreceptors ...
Shimpei Takita, Yuko Seko
doaj +3 more sources
Lrp5 functions in bone to regulate bone mass [PDF]
Nature Medicine, 2011 The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5 influences bone properties, we generated mice with osteocyte-specific expression of inducible Lrp5 mutations that cause high and low bone mass phenotypes in humans.
Yajun Cui +22 more
openalex +4 more sources
SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5 (LRP5)-dependent osteoporosis mice. [PDF]
J Zhejiang Univ Sci BXi Y +9 more
europepmc +3 more sources
Lrp5 is not required for the proliferative response of osteoblasts to strain but regulates proliferation and apoptosis in a cell autonomous manner. [PDF]
PLoS ONE, 2012 Although Lrp5 is known to be an important contributor to the mechanisms regulating bone mass, its precise role remains unclear. The aim of this study was to establish whether mutations in Lrp5 are associated with differences in the growth and/or ...
Behzad Javaheri +6 more
doaj +1 more source
Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation
Frontiers in Endocrinology, 2022 Low-density Lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis.
Iryna Khrystoforova +8 more
doaj +1 more source
TIEG1 is upregulated in Lrp5/6‐mediated valve osteogenesis [PDF]
Journal of Cellular Biochemistry, 2018 AbstractWe have previously demonstrated that Lrp5/6/β‐catenin plays an important role in valve calcification with a specific osteogenic phenotype defined by increased bone mineral content and overall valve thickening. Recent studies indicate that TIEG1 may be involved in mediating the Wnt signaling pathway in bone, which is known to play critical roles
Nalini M. Rajamannan
openalex +4 more sources
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd [PDF]
Molecular and Cellular Biology, 2004 The mechanism by which the high-bone-mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling was investigated. The mutation was previously shown to reduce DKK1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for DKK-mediated antagonism.
Yazhou, Zhang +9 more
openaire +2 more sources
LRP5 variants may contribute to ADPKD [PDF]
European Journal of Human Genetics, 2015 Mutations in Polycystic Kidney Disease proteins (PKD1 or PKD2) are causative for autosomal dominant polycystic kidney disease (ADPKD). However, a small subset of ADPKD probands do not harbor a mutation in any of the known genes. Low density lipoprotein Receptor-related Protein 5 (LRP5) was recently associated with hepatic cystogenesis in isolated ...
Cnossen, W.R. +11 more
openaire +5 more sources
LRP5 gene polymorphism and cortical bone [PDF]
Aging Clinical and Experimental Research, 2010 There is evidence that distinct genetic polymorphisms of LRP5 are associated with low Bone Mineral Density (BMD) and the risk of fracture. However, relationships between LRP5 polymorphisms and micro- and macro architectural bone characteristics assessed by pQCT have not been studied.
F. Lauretani +14 more
openaire +3 more sources