Results 221 to 230 of about 20,422 (245)

New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress. [PDF]

Antioxidants (Basel)
Zhao H, Yu F, Wu W.
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LRP5/6 in Wnt Signaling and Tumorigenesis

Future Oncology, 2005
The canonical Wnt signaling pathway is frequently overactivated in several types of human cancer. Defects in different components of the Wnt signaling pathway promote tumorigenesis and tumor progression. Accordingly, the pathway has been intensely studied to understand its importance in cancer biology and as therapeutic target.
Li, Yonghe, Bu, Guojun
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Association of LRP5 haplotypes with osteoporosis in Mexican women [PDF]

Molecular Biology Reports, 2012
Osteoporosis is a common health problem in Mexico, so it is essential to investigate the status of different gene polymorphisms that could serve as genetic susceptibility markers in the Mexican population. Genes with a role in bone metabolism are excellent candidates for association studies.
Ricardo M. Cerda-Flores, Pilar Diez-G, Edith Falcón-Ramírez, Rafael Velázquez-Cruz, Julieta Rubio-Lightbourn, Margarita Valdés-Flores, Clementina Castro-Hernández, Rosenda I. Peñaloza-Espinosa, Leonora Casas-Avila   +8 more
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Lrp5 and bone formation

Annals of the New York Academy of Sciences, 2010
Lrp5, the mutated gene in osteoporosis pseudoglioma (OPPG) and the high bone‐mass syndrome (HBM), regulates bone formation, while β‐catenin, the molecular node of Wnt signaling, regulates bone resorption, suggesting that Lrp5 could act in a Wnt‐independent manner.
Vijay K. Yadav, Patricia Ducy
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The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

Calcified Tissue International, 2008
Low-density lipoprotein receptor-related protein 5 (LRP5), a Wnt coreceptor, plays an important role in bone metabolism as loss-of-function and gain-of-function mutations in LRP5 result in the autosomal recessive osteoporosis-pseudoglioma syndrome and autosomal dominant high-bone mass (HBM) phenotypes, respectively.
Elke Piters, Wendy Balemans, Erna Cleiren, Erna Cleiren, Wim Van Hul, Minrong Ai, Matthew L. Warman, Matthew L. Warman, Liesbeth Van Wesenbeeck   +8 more
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LRP5 BIALLELIC MUTATIONS CAUSE A HIGHER INCIDENCE OF SEVERE PHENOTYPE COMPARED WITH LRP5 MONOALLELIC MUTATION

Retina, 2022
Purpose: To analyze the clinical features of LRP5 gene mutation-related familial exudative vitreoretinopathy and explore the potential phenotype–genotype correlation on LRP5 gene. Methods: Eighty-seven familial exudative vitreoretinopathy (FEVR) families with LRP5 mutations were ...
Chunli Chen, Xiang Zhang, Xiaoyan Peng, Feng Hu, Yizhe Cheng, Peiquan Zhao   +5 more
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