Results 231 to 240 of about 20,422 (245)
Some of the next articles are maybe not open access.
The effect of overexpression of Lrp5 on orthodontic tooth movement
Orthodontics & Craniofacial Research, 2020Structured AbstractObjectiveTo analyse the effect of gain‐of‐function mutations in the low‐density lipoprotein receptor‐related protein 5 (Lrp5) on orthodontic tooth movement (OTM).Setting and Sample PopulationA split‐mouth study design was utilized. Thirty‐two male Lrp5‐high bone mass (HBM) knock‐in mice including A214V and G171V mutants (n = 16/group)
Alexander G. Robling +5 more
openaire +3 more sources
Regulation of Bone Formation and Vision byLRP5
New England Journal of Medicine, 2002Osteoporosis affects several million people and is associated with medical costs of up to $15 billion per year in the United States alone.1,2 Thus, identifying the molecular mechanisms that control...
Millan S. Patel, Gerard Karsenty
openaire +3 more sources
Genetic Analysis of Lrp5 Function in Osteoblast Progenitors
Calcified Tissue International, 2010The low-density lipoprotein receptor-related protein (Lrp)-5 regulates osteoblast proliferation and bone formation through its expression in duodenum by modifying the gut serotonin-bone endocrine axis. However, its direct role, if any, in osteoblast progenitor cells has not been studied thus far.
Yadav, Vijay K. +4 more
openaire +3 more sources
LRP5: From bedside to bench to bone
Bone, 2017A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass.
openaire +3 more sources
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews in Eukaryotic Gene Expression, 2005LRP5, along with LRP6 and their Drosophila homolog, Arrow, constitute a novel subclass of the LDL receptor superfamily. The arrangement of structural motifs in these receptors is different from the other members of the superfamily, and only recently have we begun to understand the functional importance of human LRP5 (and LRP6).
Douglas T. Summerfield, Mark L. Johnson
openaire +3 more sources
LRP5 Polymorphisms and Response to Risedronate Treatment in Osteoporotic Men
Calcified Tissue International, 2009Genetic factors are important in the pathogenesis of osteoporosis, but little is known about the genetic determinants of treatment response. Previous studies have shown that polymorphisms of the LRP5 gene are associated with bone mineral density (BMD), but the relationship between LRP5 polymorphisms and response to bisphosphonate treatment in ...
Omar M. E. Albagha +2 more
openaire +3 more sources
Familial Exudative Vitreoretinopathy With a Novel LRP5 Mutation
Journal of Pediatric Ophthalmology & Strabismus, 2016This report reviews the genetics of familial exudative vitreoretinopathy (FEVR) and describes the identification of a novel variant in the LRP5 gene. A 20-month-old boy presented with reduced visual acuity in the right eye from exudative retinal detachment with mild retinal traction.
Murat Hasanreisoglu +3 more
openaire +2 more sources
Bone biomechanical properties in LRP5 mutant mice
Bone, 2004The mutation responsible for the high bone mass (HBM) phenotype has been postulated to act through the adaptive response of bone to mechanical load resulting in denser and stronger skeletons in humans and animals. The bone phenotype of members of a HBM family is characterized by normally shaped bones that are exceptionally dense, particularly at load ...
Mark L. Johnson +10 more
openaire +3 more sources
LRP5- linked osteoporosis-pseudoglioma syndrome mimicking isolated microphthalmia
European Journal of Medical Genetics, 2017Microphthalmia is defined as the measurement of the total axial length of the eyeball to be below average of the two standard deviation according to the age. While several genes have been identified so far related to microphthalmia, the genetic etiology of the disease has not been fully understood because of genetic heterogeneity observed in this ...
Sezen Guntekin Ergun +3 more
openaire +4 more sources
LRP5, a multifunctional cell surface receptor
Current Opinion in Lipidology, 2004Guojun Bu, Yonghe Li
openaire +3 more sources