Results 21 to 30 of about 20,422 (245)

Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6. [PDF]

PLoS ONE, 2011
Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6) serve as Wnt co-receptors for the canonical β-catenin pathway. While LRP6 is essential for embryogenesis, both LRP5 and LRP6 play critical roles for skeletal remodeling ...
Bryan T MacDonald, Mikhail V Semenov, He Huang, Xi He   +3 more
doaj   +1 more source

Critical Endothelial Regulation by LRP5 during Retinal Vascular Development. [PDF]

PLoS ONE, 2016
Vascular abnormalities in the eye are the leading cause of many forms of inherited and acquired human blindness. Loss-of-function mutations in the Wnt-binding co-receptor LRP5 leads to aberrant ocular vascularization and loss of vision in genetic ...
Wei Huang, Qing Li, Mahmood Amiry-Moghaddam, Madoka Hokama, Sylvia H Sardi, Masashi Nagao, Matthew L Warman, Bjorn R Olsen   +7 more
doaj   +1 more source

Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia. [PDF]

PLoS ONE, 2015
The low density lipoprotein receptor-related protein-5 (LRP5), a co-receptor in the Wnt signaling pathway, modulates bone mass in humans and in mice. Lrp5 knock-out mice have severely impaired responsiveness to mechanical stimulation whereas Lrp5 gain-of-
Paul J Niziolek, Whitney Bullock, Matthew L Warman, Alexander G Robling   +3 more
doaj   +1 more source

The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. [PDF]

PLoS ONE, 2009
BACKGROUND:Ectopic Wnt signaling induces increased stem/progenitor cell activity in the mouse mammary gland, followed by tumor development. The Wnt signaling receptors, Lrp5/6, are uniquely required for canonical Wnt activity.
Nisha M Badders, Shruti Goel, Rod J Clark, Kristine S Klos, Soyoung Kim, Anna Bafico, Charlotta Lindvall, Bart O Williams, Caroline M Alexander   +8 more
doaj   +1 more source

Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. [PDF]

PLoS ONE, 2013
The development and maintenance of retinal vasculature require a precise balance between pro-angiogenic and anti-angiogenic factors. However, mechanisms underlying normal homeostasis of retinal vasculature and pathological changes of disrupted retinal ...
Chun-hong Xia, Eric Lu, Jing Zeng, Xiaohua Gong   +3 more
doaj   +1 more source

Osteocytes and mechanical loading: The Wnt connection [PDF]

, 2019
Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y, Balemans W, Cui Y, Fu HD, Gong Y, Harris SE, Leupin O, Lim WH, Little RD, Loots GG, Niziolek PJ, Odagaki N, Ohazama A, Poole KE, Robling AG, Sawakami K, Saxon LK, Semenov M, Tu X, Van Wesenbeeck L, Zhao L, Zong Y   +21 more
core   +1 more source

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]

, 2014
The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter, Armstrong, Armstrong, Babij, Bodine, Bodine, Bonewald, Bouxsein, Boyden, Case, Choi, Dallas, Dempster, Diarra, Doube, Galea, Glass, Gong, Hens, Holmen, Holmen, Javaheri, Johnson, Johnson, Johnson, Kamel, Kato, Kitase, Korecki, Kramer, Lau, Li, Little, Logan, Lu, Monga, Nakashima, Nathke, Nusse, Pinson, Polakis, Reya, Robinson, Santos, Sawakami, Saxon, Schneider, Sen, Srivastava, Sunters, Wijenayaka, Xing, Xiong, Yao   +53 more
core   +1 more source

Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

Bone Research, 2021
Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions.
Shengzhi Liu, Di Wu, Xun Sun, Yao Fan, Rongrong Zha, Aydin Jalali, Yan Feng, Kexin Li, Tomohiko Sano, Nicole Vike, Fangjia Li, Joseph Rispoli, Akihiro Sudo, Jing Liu, Alexander Robling, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota   +17 more
doaj   +1 more source

Clinical and biochemical response to neridronate treatment in a patient with osteoporosis-pseudoglioma syndrome (OPPG) [PDF]

, 2017
Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal recessive syndrome characterized by juvenile-onset osteoporosis and ocular abnormalities due to a low-density lipoprotein receptor-related protein 5 (LRP5) gene mutation.
Celli, L, Celli, M., D'Alfonso, Y, D'Eufemia, P, Febbo, A, Persiani, P, Turchetti, A., Zambrano, A   +7 more
core   +1 more source

LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST [PDF]

Journal of Biological Chemistry, 2006
The low density lipoprotein (LDL) receptor-related protein 5 (LRP5) is a co-receptor for Wnt proteins and a major regulator in bone homeostasis. Human genetic studies have shown that recessive loss-of-function mutations in LRP5 are linked to osteoporosis, while on the contrary, dominant missense LRP5 mutations are associated with high bone mass (HBM ...
Mikhail V. Semenov, Xi He
openaire   +2 more sources