LRP5 is required for vascular development in deeper layers of the retina. [PDF]
PLoS ONE, 2010 The low-density lipoprotein receptor-related protein 5 (LRP5) plays an important role in the development of retinal vasculature. LRP5 loss-of-function mutations cause incomplete development of retinal vessel network in humans as well as in mice.
Chun-hong Xia +2 more
doaj +1 more source
Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6. [PDF]
PLoS ONE, 2011 Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6) serve as Wnt co-receptors for the canonical β-catenin pathway. While LRP6 is essential for embryogenesis, both LRP5 and LRP6 play critical roles for skeletal remodeling ...
Bryan T MacDonald +3 more
doaj +1 more source
Critical Endothelial Regulation by LRP5 during Retinal Vascular Development. [PDF]
PLoS ONE, 2016 Vascular abnormalities in the eye are the leading cause of many forms of inherited and acquired human blindness. Loss-of-function mutations in the Wnt-binding co-receptor LRP5 leads to aberrant ocular vascularization and loss of vision in genetic ...
Wei Huang +7 more
doaj +1 more source
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST [PDF]
Journal of Biological Chemistry, 2006 The low density lipoprotein (LDL) receptor-related protein 5 (LRP5) is a co-receptor for Wnt proteins and a major regulator in bone homeostasis. Human genetic studies have shown that recessive loss-of-function mutations in LRP5 are linked to osteoporosis, while on the contrary, dominant missense LRP5 mutations are associated with high bone mass (HBM ...
Mikhail V, Semenov, Xi, He
openaire +2 more sources
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. [PDF]
PLoS ONE, 2009 BACKGROUND:Ectopic Wnt signaling induces increased stem/progenitor cell activity in the mouse mammary gland, followed by tumor development. The Wnt signaling receptors, Lrp5/6, are uniquely required for canonical Wnt activity.
Nisha M Badders +8 more
doaj +1 more source
Osteocytes and mechanical loading: The Wnt connection [PDF]
, 2019 Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y +21 more
core +1 more source
LRP5, Bone Mass Polymorphisms and Skeletal Disorders
Genes, 2023 The formation and maintenance of the gross structure and microarchitecture of the human skeleton require the concerted functioning of a plethora of morphogenic signaling processes. Through recent discoveries in the field of genetics, numerous genotypic variants have been implicated in pathologic skeletal phenotypes and disorders arising from the ...
Jake Littman +4 more
openaire +2 more sources
Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. [PDF]
PLoS ONE, 2013 The development and maintenance of retinal vasculature require a precise balance between pro-angiogenic and anti-angiogenic factors. However, mechanisms underlying normal homeostasis of retinal vasculature and pathological changes of disrupted retinal ...
Chun-hong Xia +3 more
doaj +1 more source
Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone
Bone Research, 2021 Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions.
Shengzhi Liu +17 more
doaj +1 more source
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +3 more sources