Results 31 to 40 of about 21,385 (242)

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama, Alharbi, Armitage, Armitage, Armitage, Balin, Barbieri, Bergdahl, Berliner, Borilova Linhartova, Borrell-Pages, Bowling, Braak, Braak, Brown, Bu, Buchanan, Burt, Cambell, Cavrini, Chiu, Chukkapalli, Chukkapalli, Chukkapalli, Cole, Corder, Corrada, Curtiss, Cutler, De Oliveira, DeFronzo, DeStefano, Desvarieux, Duarte, Epel, Farrer, Forner, Foster, Freitag-Wolf, Galbraith, Gan, Gao, Genco, Grehan, Grossi, Habib, Haffajee, Hajishengalis, Hajishengalis, Haraszthy, Hardardottir, Hardy, Harold, Harper, Hayashi, Hayden, Heiduschka, Helfand, Het, Hitt, Holt, Hu, Huang, Hunter, Hutton, Imhof, Iqbal, Itzhaki, Jagannathachary, Joiner, Kamer, Kamer, Kamer, Katz, Khovidhunkit, Klein, Kliegel, Kolovou, Kornman, Kozarov, Kubota, Lalla, Lambert, Lesne, Leszcynska, Libby, Machado, Mahley, Mahley, Mahley, Mahley, Maney, Marti, McGeer, Michalowicz, Miklossy, Miklossy, Miller, Mooradian, Moutsopoulos, Nagpal, Neto, Nicoll, Noble, Okuda, Olsen, Ono, O’Brien, Papapanou, Perls, Pitas, Pizzo, Poirier, Poling, Poole, Poole, Rivera, Riviere, Rogers, Rohn, Roses, Roses, Rowe, Saito, Saunders, Scannapieco, Schuett, Shao, Singhrao, Singhrao, Singhrao, Singhrao, Small, Smit, Socransky, Soscia, Stein, Strittmatter, Strittmatter, Sullivan, Velsko, Walsh, Walsh, Watkins, Weisgraber, Wetterau, Wilson, Young   +147 more
core   +1 more source

Modulation of β-catenin signaling by glucagon receptor activation. [PDF]

PLoS ONE, 2012
The glucagon receptor (GCGR) is a member of the class B G protein-coupled receptor family. Activation of GCGR by glucagon leads to increased glucose production by the liver.
Jiyuan Ke, Chenghai Zhang, Kaleeckal G Harikumar, Cassandra R Zylstra-Diegel, Liren Wang, Laura E Mowry, Laurence J Miller, Bart O Williams, H Eric Xu   +8 more
doaj   +1 more source

Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]

, 2019
Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana, Hesse, Eric, Pamperin, Jenny, Saito, Hiroaki, Schröder, Saskia, Taipaleenmäki, Hanna   +5 more
core   +1 more source

LRP5 and LRP6 in development and disease [PDF]

Trends in Endocrinology & Metabolism, 2012
Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions ...
Danese M. Joiner, Jiyuan Ke, Zhendong Zhong, H. Eric Xu, Bart O. Williams   +4 more
openalex   +4 more sources

Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer [PDF]

, 2015
Introduction Aromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common.
A Mackay, AK Dunbier, AK Dunbier, Alan Mackay, Alexey Larionov, Anita K Dunbier, Aradhana Rani, Ash Nerurkar, B Weigelt, BP Coe, C Curtis, C Kent, D Generali, DG Albertson, DS Tan, Elena López-Knowles, F Kreisel, Helen Anderson, HW Cheung, IE Smith, IE Smith, J Hicks, J Michael Dixon, Jorge S Reis-Filho, JS Foster, K Lundgren, L Osterberg, LA Martin, LA Martin, LA Martin, Lesley-Ann Martin, LG Leon, Lorna Renshaw, M Dowsett, M Mello-Grand, M Scaltriti, Mitch Dowsett, MJ Ellis, MT Weigel, N Turner, P Darbre, P Lal, Paul M Wilkerson, Peter Osin, PM Wilkerson, PM Wilkerson, PT Simpson, R Beroukhim, R Duprez, R Katz-Brull, R Natrajan, R Natrajan, R Natrajan, Ricardo Ribas, T Miyake, T Troiani, TK Lam, William R Miller, WR Miller, WR Miller, WR Miller, WR Miller, X Huo, Y Zhao, Z Ghazoui, Zara Ghazoui   +65 more
core   +3 more sources

Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37

Cell Communication and Signaling, 2019
Background LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important component of the nuclear pore complex
Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Weidong Zhu, Yong Fang, Dan-ni Ren   +7 more
doaj   +1 more source

LRP5-Mediated Lipid Uptake Modulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2021
Nutritional microenvironment determines the specification of progenitor cells, and lipid availability was found to modulate osteogenesis in skeletal progenitors.
Jiachen Lin, Jiachen Lin, Zhifa Zheng, Jieying Liu, Guihua Yang, Ling Leng, Hai Wang, Guixing Qiu, Zhihong Wu   +8 more
doaj   +1 more source

The Investigation of LRP5-Loaded Composite with Sustained Release Behavior and Its Application in Bone Repair

International Journal of Polymer Science, 2019
Low-density lipoprotein receptor-related protein 5 (LRP5) plays a vital role in bone formation and regeneration. In this study, we developed an injectable and sustained-release composite loading LRP5 which could gelatinize in situ.
Yanhai Xi, Tingwang Jiang, Jiangming Yu, Mintao Xue, Ning Xu, Jiankun Wen, Weiheng Wang, Hailong He, Xiaojian Ye   +8 more
doaj   +1 more source

The regulation of differentiation in mesenchymal stem cells [PDF]

, 2010
Peer reviewedPublisher ...
Augello, Andrea, De Bari, Cosimo
core   +1 more source

Clinical and biochemical response to neridronate treatment in a patient with osteoporosis-pseudoglioma syndrome (OPPG) [PDF]

, 2017
Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal recessive syndrome characterized by juvenile-onset osteoporosis and ocular abnormalities due to a low-density lipoprotein receptor-related protein 5 (LRP5) gene mutation.
Celli, L, Celli, M., D'Alfonso, Y, D'Eufemia, P, Febbo, A, Persiani, P, Turchetti, A., Zambrano, A   +7 more
core   +1 more source