Results 31 to 40 of about 20,422 (245)

Development of the Bone Phenotype and microRNA Profile in Adults With Low‐Density Lipoprotein Receptor‐Related Protein 5–High Bone Mass (LRP5‐HBM) Disease

JBMR Plus, 2021
Pathogenic variants in the Wnt‐pathway co‐receptor low‐density lipoprotein (LDL) receptor‐related protein 5 (LRP5) cause high bone mass (LRP5‐HBM) due to insensitivity to the endogenous antagonist of Wnt‐signaling.
Jens‐Jacob Lindegaard Lauterlein, Fatma Gossiel, Moritz Weigl, Richard Eastell, Matthias Hackl, Pernille Hermann, Jens Bollerslev, Morten Frost   +7 more
doaj   +1 more source

LRP5-Mediated Lipid Uptake Modulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2021
Nutritional microenvironment determines the specification of progenitor cells, and lipid availability was found to modulate osteogenesis in skeletal progenitors.
Jiachen Lin, Jiachen Lin, Zhifa Zheng, Jieying Liu, Guihua Yang, Ling Leng, Hai Wang, Guixing Qiu, Zhihong Wu   +8 more
doaj   +1 more source

Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry

Therapeutics and Clinical Risk Management, 2021
Masaki Nakano,1,* Haruka Yui,1,* Shingo Kikugawa,2 Ryosuke Tokida,3 Noriko Sakai,4 Naoki Kondo,5 Naoto Endo,5 Hirotaka Haro,6 Hiroki Shimodaira,1 Takako Suzuki,1,7 Hiroyuki Kato,1 Jun Takahashi,1 Yukio Nakamura1 1Department of Orthopaedic Surgery,
Nakano M, Yui H, Kikugawa S, Tokida R, Sakai N, Kondo N, Endo N, Haro H, Shimodaira H, Suzuki T, Kato H, Takahashi J, Nakamura Y   +12 more
doaj  

The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells. [PDF]

PLoS ONE, 2013
While Mesd was discovered as a specialized molecular endoplasmic reticulum chaperone for the Wnt co-receptors LRP5 and LRP6, recombinant Mesd protein is able to bind to mature LRP5 and LRP6 on the cell surface and acts as a universal antagonist of LRP5/6
Cuihong Lin, Wenyan Lu, Wei Zhang, Angelina I Londoño-Joshi, Donald J Buchsbaum, Guojun Bu, Yonghe Li   +6 more
doaj   +1 more source

Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]

, 2017
Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita, He, Guangxu, Lim, Joohyun, Long, Fanxin, Ni, Jiangdong, Shi, Yu   +5 more
core   +2 more sources

The role of Lrp5/6 in cardiac valve disease: Experimental hypercholesterolemia in the ApoE−/−/Lrp5−/− mice [PDF]

Journal of Cellular Biochemistry, 2011
Lrp5/6 co-receptor is known to play a role in bone formation and lipid metabolism. This gene encodes a member of the low-density lipoprotein (LDL) receptor gene family. This study tests the hypothesis that Lrp5/6 is necessary for the development of valve calcification in experimental hypercholesterolemia.
openaire   +3 more sources

LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma

Genes, 2023
Cell proliferation and invasion are characteristic of many tumors, including ameloblastoma, and are important features to target in possible future therapeutic applications. Objective: The objective of this study was the identification of key genes and inhibitory drugs related to the cell proliferation and invasion of ameloblastoma using bioinformatic ...
Lorena Correa-Arzate, Javier Portilla-Robertson, Josué Orlando Ramírez-Jarquín, Luis Fernando Jacinto-Alemán, Claudia Patricia Mejía-Velázquez, Francisco Germán Villanueva-Sánchez, Mariana Rodríguez-Vázquez   +6 more
openaire   +2 more sources

The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish. [PDF]

PLoS ONE, 2015
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mesenchymal transition (EMT), delaminate from the neural plate border, and migrate as separate streams into different cranial regions.
Bernd Willems, Shijie Tao, Tingsheng Yu, Ann Huysseune, Paul Eckhard Witten, Christoph Winkler   +5 more
doaj   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
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core   +1 more source

Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37

Cell Communication and Signaling, 2019
Background LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important component of the nuclear pore complex
Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Weidong Zhu, Yong Fang, Dan-ni Ren   +7 more
doaj   +1 more source